Induction of p21Waf1/Cip1 by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 9, 2014, Pages 2085-2095

  Yu, Sheng Yung ^a   Liao, Chiung Ho ^b   Chien, Ming Hsien ^c,d   Tsai, Tsung Yu ^a   Lin, Jen Kun ^e   Weng, Meng Shih ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b Executive Yuan   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

G1 arrest; garcinol; lung cancer; p21Waf1 Cip1; p38 MAPK; p53

Indexed keywords

G1 ARREST; GARCINOL; LUNG CANCER; P21WAF1/CIP1; P38-MAPK; P53; P38 MAPK;

BIOLOGICAL ORGANS; CELL DEATH; DISEASES; ENZYMES; PROTEINS; CELLS; CYTOLOGY;

CELL SIGNALING;

GARCINIA INDICA;

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GARCINOL; PLANT EXTRACT; PROTEIN P53; TERPENE;

APOPTOSIS; ARTICLE; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; GARCINIA; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; GARCINIA; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; PLANT EXTRACTS; TERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84897716436     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4037722     Document Type: Article

References (42)

1. Lee, K. W.; Bode, A. M.; Dong, Z. Molecular targets of phytochemicals for cancer prevention Nat. Rev. Cancer 2011, 11, 211-218
2. Sarkar, F. H.; Li, Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics Cancer Treat. Rev. 2009, 35, 597-607
3. Padhye, S.; Ahmad, A.; Oswal, N.; Sarkar, F. H. Emerging role of garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs J. Hematol. Oncol. 2009, 2, 38
4. Liao, C. H.; Ho, C. T.; Lin, J. K. Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes Biochem. Biophys. Res. Commun. 2005, 329, 1306-1314
5. Yamaguchi, F.; Saito, M.; Ariga, T.; Yoshimura, Y.; Nakazawa, H. Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind J. Agric. Food Chem. 2000, 48, 2320-2325
6. Liao, C. H.; Sang, S.; Liang, Y. C.; Ho, C. T.; Lin, J. K. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-κB pathway by garcinol Mol. Carcinog. 2004, 41, 140-149
7. Ahmad, A.; Sarkar, S. H.; Aboukameel, A.; Ali, S.; Biersack, B.; Seibt, S.; Li, Y.; Bao, B.; Kong, D.; Banerjee, S.; Schobert, R.; Padhye, S. B.; Sarkar, F. H. Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling Carcinogenesis 2012, 33, 2450-2456
8. Ahmad, A.; Wang, Z.; Ali, R.; Maitah, M. Y.; Kong, D.; Banerjee, S.; Padhye, S.; Sarkar, F. H. Apoptosis-inducing effect of garcinol is mediated by NF-κB signaling in breast cancer cells J. Cell. Biochem. 2010, 109, 1134-1141
9. Prasad, S.; Ravindran, J.; Sung, B.; Pandey, M. K.; Aggarwal, B. B. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins Mol. Cancer Ther. 2010, 9, 856-868
10. Chen, C. S.; Lee, C. H.; Hsieh, C. D.; Ho, C. T.; Pan, M. H.; Huang, C. S.; Tu, S. H.; Wang, Y. J.; Chen, L. C.; Chang, Y. J.; Wei, P. L.; Yang, Y. Y.; Wu, C. H.; Ho, Y. S. Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins Breast Cancer Res. Treat. 2011, 125, 73-87
11. Liao, C. H.; Sang, S.; Ho, C. T.; Lin, J. K. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells J. Cell. Biochem. 2005, 96, 155-169
12. Cheng, A. C.; Tsai, M. L.; Liu, C. M.; Lee, M. F.; Nagabhushanam, K.; Ho, C. T.; Pan, M. H. Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis Food Funct. 2010, 1, 301-307
13. Tanaka, T.; Kohno, H.; Shimada, R.; Kagami, S.; Yamaguchi, F.; Kataoka, S.; Ariga, T.; Murakami, A.; Koshimizu, K.; Ohigashi, H. Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats Carcinogenesis 2000, 21, 1183-1189
14. Jemal, A.; Bray, F.; Center, M. M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics Ca-Cancer J. Clin. 2011, 61, 69-90
15. Viktorsson, K.; De Petris, L.; Lewensohn, R. The role of p53 in treatment responses of lung cancer Biochem. Biophys. Res. Commun. 2005, 331, 868-880
16. Steels, E.; Paesmans, M.; Berghmans, T.; Branle, F.; Lemaitre, F.; Mascaux, C.; Meert, A. P.; Vallot, F.; Lafitte, J. J.; Sculier, J. P. Role of p53 as a prognostic factor for survival in lung cancer: A systematic review of the literature with a meta-analysis Eur. Respir. J. 2001, 18, 705-719
17. Bodner, S. M.; Minna, J. D.; Jensen, S. M.; D'Amico, D.; Carbone, D.; Mitsudomi, T.; Fedorko, J.; Buchhagen, D. L.; Nau, M. M.; Gazdar, A. F. Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation Oncogene 1992, 7, 743-749
18. Hodkinson, P. S.; Mackinnon, A.; Sethi, T. Targeting growth factors in lung cancer Chest 2008, 133, 1209-1216
19. Malumbres, M.; Barbacid, M. Cell cycle, CDKs and cancer: A changing paradigm Nat. Rev. Cancer 2009, 9, 153-166
20. Eymin, B.; Gazzeri, S. Role of cell cycle regulators in lung carcinogenesis Cell Adhes. Migr. 2010, 4, 114-123
21. Hartwell, L. H.; Weinert, T. A. Checkpoints: Controls that ensure the order of cell cycle events Science 1989, 246, 629-634
22. Sherr, C. J.; Roberts, J. M. CDK inhibitors: Positive and negative regulators of G1-phase progression Genes Dev. 1999, 13, 1501-1512
23. Abbas, T.; Dutta, A. p21 in cancer: Intricate networks and multiple activities Nat. Rev. Cancer 2009, 9, 400-414
24. Baldi, A.; De Luca, A.; Esposito, V.; Campioni, M.; Spugnini, E. P.; Citro, G. Tumor suppressors and cell-cycle proteins in lung cancer Pathol. Res. Int. 2011, 2011, 605042
25. Parasramka, M. A.; Gupta, S. V. Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells Nutr. Cancer 2011, 63, 456-465
26. Plotnikov, A.; Zehorai, E.; Procaccia, S.; Seger, R. The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation Biochim. Biophys. Acta 2011, 1813, 1619-1633
27. Faust, D.; Schmitt, C.; Oesch, F.; Oesch-Bartlomowicz, B.; Schreck, I.; Weiss, C.; Dietrich, C. Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts Cell Commun. Signaling 2012, 10, 6
28. Han, J.; Sun, P. The pathways to tumor suppression via route p38 Trends Biochem. Sci. 2007, 32, 364-371
29. Weng, M. S.; Ho, Y. S.; Lin, J. K. Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase Biochem. Pharmacol. 2005, 69, 1815-1827
30. Cip1 by phosphorylation J. Biol. Chem. 2002, 277, 29792-29802
31. Chen, L.; Mayer, J. A.; Krisko, T. I.; Speers, C. W.; Wang, T.; Hilsenbeck, S. G.; Brown, P. H. Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells Cancer Res. 2009, 69, 8853-8861
32. Halawani, D.; Mondeh, R.; Stanton, L. A.; Beier, F. p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation Oncogene 2004, 23, 3726-3731
33. Greenberg, A. K.; Basu, S.; Hu, J.; Yie, T. A.; Tchou-Wong, K. M.; Rom, W. N.; Lee, T. C. Selective p38 activation in human non-small cell lung cancer Am. J. Respir. Cell Mol. Biol. 2002, 26, 558-5564
34. Recio, J. A.; Merlino, G. Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1 Oncogene 2002, 21, 1000-1008
35. Maher, P. p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation J. Biol. Chem. 1999, 274, 17491-17498
36. Yamaguchi, F.; Ariga, T.; Yoshimura, Y.; Nakazawa, H. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind J. Agric. Food Chem. 2000, 48, 180-185
37. Vogt, U.; Zaczek, A.; Klinke, F.; Granetzny, A.; Bielawski, K.; Falkiewicz, B. p53 gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer J. Cancer Res. Clin. Oncol. 2002, 128, 141-147
38. Oike, T.; Ogiwara, H.; Torikai, K.; Nakano, T.; Yokota, J.; Kohno, T. Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining Int. J. Radiat. Oncol., Biol., Phys. 2012, 84, 815-821
39. Collins, H. M.; Abdelghany, M. K.; Messmer, M.; Yue, B.; Deeves, S. E.; Kindle, K. B.; Mantelingu, K.; Aslam, A.; Winkler, G. S.; Kundu, T. K.; Heery, D. M. Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells BMC Cancer 2013, 13, 37
40. Yang, S. H.; Sharrocks, A. D.; Whitmarsh, A. J. MAP kinase signalling cascades and transcriptional regulation Gene 2013, 513, 1-13
41. Oh, J. H.; Ban, J. O.; Cho, M. C.; Jo, M.; Jung, J. K.; Ahn, B.; Yoon, D. Y.; Han, S. B.; Hong, J. T. 4-O -Methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity J. Nutr. Biochem. 2012, 23, 706-715
42. Hellin, A. C.; Bentires-Alj, M.; Verlaet, M.; Benoit, V.; Gielen, J.; Bours, V.; Merville, M. P. Roles of nuclear factor-κB, p53, and p21/WAF1 in daunomycin-induced cell cycle arrest and apoptosis J. Pharmacol. Exp. Ther. 2000, 295, 870-878