Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 13, 2014, Pages 4982-4987

  Sherman, David J ^a   Lazarus, Michael B ^a,b   Murphy, Lea ^b   Liu, Charles ^a   Walker, Suzanne ^b   Ruiz, Natividad ^b   Kahne, Daniel ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

ABC transporter; Antibiotic target; Membrane biogenesis

Indexed keywords

ABC TRANSPORTER; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LPTB PROTEIN; NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MEMBRANE; BIOCHEMISTRY; BIOLOGICAL ACTIVITY; CARBOHYDRATE TRANSPORT; CATALYSIS; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; EXTRACTION; HYDROLYSIS; IN VIVO STUDY; MEMBRANE LEAFLET; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION;

ABC TRANSPORTER; ANTIBIOTIC TARGET; MEMBRANE BIOGENESIS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACIDS; ATP-BINDING CASSETTE TRANSPORTERS; BIOCATALYSIS; BIOLOGICAL TRANSPORT; CATALYTIC DOMAIN; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; LIPOPOLYSACCHARIDES; MICROBIAL VIABILITY; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 84897544524     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323516111     Document Type: Article

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