Design, synthesis, and biological evaluation of dihydroartemisinin- fluoroquinolone conjugates as a novel type of potential antitubercular agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1912-1917

  Zhou, Fu Wei ^a   Lei, Huang Shu ^b   Fan, Li ^a   Jiang, Li ^c   Liu, Jian ^a   Peng, Xin Mei ^a   Xu, Xing Ran ^a   Chen, Li ^a   Zhou, Cheng He ^a   Zou, Yan Ye ^b   Liu, Cai Ping ^b   He, Zhi Qin ^b   Yang, Da Cheng ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Chongqing Pharmaceutical Research Institute Co Ltd   (China)

^c SCHLUMBERGER   (United States)

Author keywords

Antibacterial activity; Antitubercular activity; Artemisinin; Dihydroartemisinin; Fluoroquinolone

Indexed keywords

8 CHLORO 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 (3 ((2 ((3,6,9 TRIMETHYLDECAHYDRO 3H 3,12 EPOXY[1,2]DIOXEPINO[4,3 I]ISOCHROMEN 10 YL)OXY)ETHYL)AMINO)PYRROLIDIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; DIHYDROARTEMISININ DERIVATIVE; MOXIFLOXACIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONJUGATE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

MYCOBACTERIUM TUBERCULOSIS;

ANTIBACTERIAL ACTIVITY; ANTITUBERCULAR ACTIVITY; ARTEMISININ; DIHYDROARTEMISININ; FLUOROQUINOLONE;

ANTITUBERCULAR AGENTS; ARTEMISININS; DRUG DESIGN; FLUOROQUINOLONES; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897543315     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.010     Document Type: Article

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