Aromatic amino analogues of artemisinin: Synthesis and in vivo antimalarial activity

Medicinal Chemistry Research

Volumn 19, Issue 6, 2010, Pages 524-532

  Sriram, Dharmarajan ^a   Devakaram, Ruth Vandana ^a   Dinakaran, Murugesan ^a   Yogeeswari, Perumal ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antimalarial activity; Artemisinin; Plasmodium yoelii nigeriensis

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; N [4 HYDROXY 3 [(4 PHENYLPIPERAZIN 1 YL)METHYL)PHENYL]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PLASMODIUM MALARIAE INFECTION; PLASMODIUM YOELII;

EID: 77956457837     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9209-5     Document Type: Article

References (7)

1. Brewer TG, Grate SJ, Peggins JO, Weina PJ, Petras JM, Levine BS (1994) Fatal neurotoxicity of arteether and artemether. Am J Trop Med Hyg 51:251
2. Frenkel YV, Clark AD, Das K, Wang YH, Lewis PJ, Janssen PAJ, Arnold E (2005) Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. J Med Chem 48:1974. doi:10.1021/jm049439i
3. Peters W, Robinson B (1998) Section IV. In: Zack O, Sande M (eds) Malaria. Academic Press, London, pp 756-771
4. Lin AJ, Li LQ, Klayman DL, George CF, Flippen-Anderson JL (1990) Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 3. Aromatic amine analogues. J Med Chem 33:2610. doi:10.1021/jm00171a041
5. Lin AJ, Li LQ, Anderson SL, Klayman DL (1992) Antimalarial activity of new dihydroartemisinin derivatives. 5. Sugar analogues. J Med Chem 35:1639. doi:10.1021/jm00087a021
6. Peters W, Robinson B (2000) The chemotherapy of rodent malaria. LVIII. Drug combinations to impede the selection of drug resistance, Part. 2: the new generation-artemisinin or artesunate with longacting blood schizontocides. Ann Trop Med Parasitol 94:23. doi:10.1080/00034980057581
7. Sriram D, Rao VS, Chandrasekhar KVG, Yogeeswari P (2004) Progress in the research of artemisinin and its analogues as antimalarials: an update. Nat Prod Res 18:503. www.who.int/mediacentre/fact sheets/fs094/en/index.html. doi:10.1080/14786410310001620556