Pulmonary delivery and tissue distribution of aerosolized antisense 2′-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 478-485

  Dong, M ^a,b   Murdter T E ^a,b,e   Philippi, C ^c   Loretz, B ^c,d   Schaefer, U F ^c   Lehr, C M ^c,d   Schwab, M ^a,b,e   Ammon Treiber, S ^a,b,e  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

2 O Methyl RNA; Inhalation; Isolated perfused and ventilated rat lung; Nanoplexes; Targeted therapy

Indexed keywords

ANTISENSE 2' O METHYL RNA; COMPLEMENTARY RNA; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TOLERABILITY; DRUG UPTAKE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; RAT; RESPIRATORY EPITHELIUM;

AEROSOLS; ANIMALS; CHITOSAN; LACTIC ACID; LUNG; MALE; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; RNA, ANTISENSE; TISSUE DISTRIBUTION;

EID: 84863777799     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.04.022     Document Type: Article

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