Synthesis and in vitro biological evaluation of hybrids from tetrahydro-β-carboline and hydroxylcinnamic acid as antitumor carcinoma agents

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 4, 2014, Pages 343-349

  Lin, Ying ^a   Xia, Xuanping ^a   Yao, Rongxin ^a   Ni, Li ^a   Hu, Jie ^a   Guo, Wenjian ^a   Zhu, Baoling ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Anti tumor agent; Cell apoptosis; Hydroxylcinnamic acid; Inhibitory activity; Synthesis; Tetrahydro carboline

Indexed keywords

2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL] 9 (3 MORPHOLINOPROPYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (PIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (PIPERIDIN1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3(PYRROLIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXYPHENYL)ACRYLOYL] 9 (3 MORPHOLINOPROPYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXYPHENYL)ACRYLOYL] 9 [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXYPHENYL)ACRYLOYL] 9 [3 (PIPERAZIN 1YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXYPHENYL)ACRYLOYL] 9 [3 (PIPERIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 2 [3 (4 HYDROXYPHENYL)ACRYLOYL] 9 [3 (PYRROLIDIN 1YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; CINNAMIC ACID DERIVATIVE; DOXORUBICIN; FLUOROURACIL; METHYL 2 [3 (4 ACETOXY 3 METHOXYPHENYL)ACRYLOYL] 9 (3 MORPHOLINOPROPYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (METHYLPIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (PIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (PIPERIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXY 3 METHOXYPHENYL)ACRYLOYL] 9 [3 (PYRROLIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXYPHENYL)ACRYLOYL] 9 (3 MORPHOLINOPROPYL) 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXYPHENYL)ACRYLOYL] 9 [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXYPHENYL)ACRYLOYL] 9 [3 (PIPERAZIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXYPHENYL)ACRYLOYL] 9 [3 (PIPERIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; METHYL 2 [3 (4 ACETOXYPHENYL)ACRYLOYL] 9 [3 (PYRROLIDIN 1 YL)PROPYL] 2,3,4,9 TETRAHYDRO 1H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; TRYPTOLINE DERIVATIVE; UNCLASSIFIED DRUG; CARBOLINE DERIVATIVE; CINNAMIC ACID; TRYPTOLINE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; COLON CARCINOMA; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CARCINOMA; OVARY CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CANCER; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897494792     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00902     Document Type: Article

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