Oxidative metabolism of the bioactive and naturally occurring β-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes

Chemical Research in Toxicology

Volumn 21, Issue 11, 2008, Pages 2172-2180

  Herraiz, Tomás ^a   Guillén, Hugo ^a   Arán, Vicente J ^b  

^a INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY BETA CARBOLINE; 3 HYDROXYHARMAN; 3 HYDROXYNORHARMAN; 6 HYDROXY BETA CARBOLINE; 6 HYDROXYHARMAN; 6 HYDROXYNORHARMAN; ALKALOID DERIVATIVE; BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; BETA CARBOLINE N 2 OXIDE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; HARMAN; HARMAN 2 OXIDE; HETEROCYCLIC AMINE; NORHARMAN 2 OXIDE; POLYCYCLIC HYDROCARBON; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LIVER MICROSOME; MEDICAL RESEARCH; OXIDATION;

CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; HARMINE; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; OXIDATION-REDUCTION;

NICOTIANA TABACUM;

EID: 57449102342     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx8002565     Document Type: Article

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