Indoxyl sulfate downregulates expression of mas receptor via OAT3/AhR/stat3 pathway in proximal tubular cells

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Ng, Hwee Yeong ^a,b   Yisireyili, Maimaiti ^a   Saito, Shinichi ^a   Lee, Chien Te ^b   Adelibieke, Yelixiati ^a   Nishijima, Fuyuhiko ^c   Niwa, Toshimitsu ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c KUREHA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN[1-7]; AROMATIC HYDROCARBON RECEPTOR; AST 120; ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR; INDICAN; MAS RECEPTOR; ORGANIC ANION TRANSPORTER 3; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ANGIOTENSIN DERIVATIVE; ONCOPROTEIN; ORGANIC ANION TRANSPORTER; PROTO-ONCOGENE PROTEINS C-MAS-1; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY TUBULE CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; ANIMAL; BIOLOGICAL MODEL; CHRONIC KIDNEY FAILURE; CYTOLOGY; DAHL RAT; DOWN REGULATION; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME;

ACETYLCYSTEINE; ANGIOTENSINS; ANIMALS; DOWN-REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INDICAN; KIDNEY TUBULES, PROXIMAL; MALE; MODELS, BIOLOGICAL; NITRIC OXIDE SYNTHASE TYPE III; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RATS, INBRED DAHL; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, G-PROTEIN-COUPLED; RENAL INSUFFICIENCY, CHRONIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84897493761     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091517     Document Type: Article

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