In vivo evaluation and in-depth pharmaceutical characterization of a rapidly dissolving solid ocular matrix for the topical delivery of timolol maleate in the rabbit eye model

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 296-306

  Moosa, Raeesa M ^a   Choonara, Yahya E ^a   Du Toit, Lisa C ^a   Tomar, Lomas K ^a   Tyagi, Charu ^a   Kumar, Pradeep ^a   Carmichael, Trevor R ^a   Pillay, Viness ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

HET CAM; In vitro in vivo correlation; Lyophilized polymer matrix; Ocular delivery; Timolol maleate

Indexed keywords

DICLOFENAC; EYE DROPS; TIMOLOL MALEATE; ANTIHYPERTENSIVE AGENT; TIMOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; DRUG FORMULATION; DRUG SCREENING; EYE TOXICITY; GAMMA IRRADIATION; HISTOPATHOLOGY; IN VIVO STUDY; NONHUMAN; PERMEABILITY; PHARMACEUTICS; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RABBIT; RAPIDLY DISSOLVING SOLID OCULAR MATRIX; STEADY STATE; THERMAL ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CHICK EMBRYO; CHORIOALLANTOIS; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EYE; IN VITRO STUDY; INTRAOCULAR DRUG ADMINISTRATION; METABOLISM; SOLUBILITY;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIHYPERTENSIVE AGENTS; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; DRUG DELIVERY SYSTEMS; EYE; IN VITRO TECHNIQUES; OPHTHALMIC SOLUTIONS; PERMEABILITY; RABBITS; SOLUBILITY; TIMOLOL;

EID: 84897471976     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.032     Document Type: Article

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