Characterization and in vivo evaluation of ocular minitablets prepared with different bioadhesive Carbopol-starch components

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 62, Issue 2, 2006, Pages 202-209

  Weyenberg, W ^a   Bozdag, S ^a,b   Foreman, P ^c   Remon, J P ^d   Ludwig, A ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b HACETTEPE UNIVERSITY   (Turkey)

^c NATIONAL STARCH AND CHEMICAL COMPANY   (United States)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

Bioerodible; Carbopol; In vitro release; In vivo study; Ocular minitablet; Starch

Indexed keywords

AMIOCA; CARBOPOL 974P; FLUORESCEIN SODIUM; STARCH;

ADHESION; ARTICLE; DRUG MIXTURE; GAMMA IRRADIATION; IN VITRO STUDY; IN VIVO STUDY; POWDER; SUSTAINED RELEASE PREPARATION; TABLET FORMULATION; VISCOSITY;

ADMINISTRATION, TOPICAL; ADULT; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DESICCATION; EYE; FEMALE; FLUORESCEIN; GAMMA RAYS; HARDNESS; HUMANS; MALE; PARTICLE SIZE; POLYVINYLS; POWDERS; SOLUBILITY; STARCH; TABLETS; TISSUE ADHESIVES; VISCOSITY;

EID: 31344435069     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.08.003     Document Type: Article

References (16)

1. F. Gurtler, V. Kaltsatos, B. Boisramé, J. Deleforge, M. Gex-Fabry, L.P. Balant, and R. Gurny Ocular availability of gentamicin in small animals after topical administration of a conventional eye drop solution and a novel long acting bioadhesive ophthalmic drug insert Pharm. Res. 12 1995 1791 1795
2. C. Le Bourlais, L. Acar, H. Zia, P.A. Sado, T. Needham, and R. Leverge Ophthalmic Drug Delivery Systems - Recent Advances Prog. Retin. Eye Res. 17 1998 33 58
3. J. Ceulemans, A. Vermeire, E. Adriaens, J.P. Remon, and A. Ludwig Evaluation of a mucoadhesive tablet for ocular use J. Control. Release 77 2001 333 344
4. W. Weyenberg, A. Vermeire, J.P. Remon, and A. Ludwig Characterization and evaluation of ocular bioadhesive minitablets compressed at different forces J. Control. Release 89 2003 329 340
5. W. Weyenberg, A. Vermeire, E. D'Haese, G. Vanhaelewyn, P. Kestelyn, F. Callens, H.J. Nelis, J.P. Remon, and A. Ludwig Effect of different sterilisation methods on the properties of bioadhesive powders and ocular minitablets, and clinical evaluation. Eur. J. Pharm. Sci. 23 1 2004 77 87
6. D. Ameye, J. Voorspoels, P. Foreman, J. Tsai, P. Richardson, S. Geresh, and J.P. Remon Ex vivo bioadhesion and in vivo testosterone bioavailability study of different bioadhesive formulations based on starch-g-poly(acrylic) acid copolymers and starch/poly(acrylic acid) mixtures J. Control. Release 79 2002 173 182
7. S. Bouckaert, and J.P. Remon In vitro bioadhesion of a buccal, miconazole slow-release tablet J. Pharm. Pharmacol. 45 1993 504 507
8. P.B. Morgan, A.B. Tullo, and N. Efron Infrared thermography of the tear film in dry eye Eye 9 1995 615 618
9. W. Weyenberg, V. Todorov, and A. Ludwig Rheological evaluation of the influence of sterilisation on ocular gels using an experimental design Die Pharmazie 59 2 2004 121 125
10. A.S. Deschrieder Changes in starch and its degradation products on irradiating wheat flour with gamma rays Starch/Stärke 12 1960 197 198
11. T. Sebhatu, M. Angberg, and C. Ahlneck Assessment of the degree of disorder in crystalline solids Int. J. Pharm. 101 1994 237 247
12. S. Malkowska, and K.A. Khan Effect of recompression on the properties of tablets prepared by dry granulation Drug Dev. Ind. Pharm. 9 1983 331 347
13. P. Kleinebudde Review article: Roll compaction/dry granulation: pharmaceutical applications Eur. J. Pharm. Biopharm. 58 2004 317 326
14. V. Michailova, S. Titeva, R. Kotsilkova, E. Krusteva, and E. Minkov Water uptake and relaxation processes in mixed unlimited swelling hydrogels Int. J. Pharm. 209 2000 45 56
15. ® 974P mixtures J. Control. Release 88 2003 393 399
16. M.F. Saettone, P. Chetoni, L.M. Bianchi, B. Giannaccini, U. Conte, and M.E. Sangali Controlled release of timolol maleate from coated opththalmic mini-tablets prepared by compression Int. J. Pharm. 126 1995 79 82