Effects of lyophilization on the physical characteristics and chemical stability of amorphous quinapril hydrochloride

Pharmaceutical Research

Volumn 17, Issue 8, 2000, Pages 930-935

  Guo, Y ^a,c   Byrn, S R ^b   Zografi, G ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b PURDUE UNIVERSITY   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

ACE inhibitor; Amorphous; Chemical degradation; Glass transition temperature; Lyophilization; Quinapril hydrochloride

Indexed keywords

QUINAPRIL;

AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; DRUG STABILITY; FREEZE DRYING; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID STATE; TEMPERATURE;

ALGORITHMS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; DRUG STABILITY; FREEZE DRYING; HELIUM; HYDROGEN-ION CONCENTRATION; ISOQUINOLINES; KINETICS; TETRAHYDROISOQUINOLINES;

EID: 0033795715     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007519003070     Document Type: Article

References (9)

1. Physical characteristics and chemical degradation of amorphous quinapril hydrochloride
2. Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types
3. An unexpected pH effect on the stability of moexipril lyophilized powder
4. Ideal copolymers and the second-order transitions of synthetic rubbers. I. Non-crystalline copolymers
5. On a general relation involving the glass temperature and coefficient of expansion of polymers
6. A classical thermodynamic discussion on the effect of composition on glass-transition temperatures
7. Nonexponential relaxations in strong and fragile glass formers
8. Dependence of glass transition temperature on heating and cooling rate
9. Precision neutron diffraction structure determination of protein and nucleic acid compounds. III. The crystal and molecular structure of the amino acid a-glycine