Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Zhang, Min ^a   Chai, Yang D ^a   Brumbaugh, Jeffrey ^a   Liu, Xiaojun ^a   Rabii, Ramin ^a   Feng, Sizhe ^a   Misuno, Kaori ^a   Messadi, Diana ^a,b   Hu, Shen ^a,b  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; GLUCOSE; GLUTAMINE; LACTIC ACID; PENTOSE PHOSPHATE; SMALL INTERFERING RNA; TRANSKETOLASE;

AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEEDBACK SYSTEM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MOUTH CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TONGUE CARCINOMA; WESTERN BLOTTING;

ADENYLATE KINASE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; GLUTAMINE; HUMANS; LACTIC ACID; MOUTH NEOPLASMS; RNA, SMALL INTERFERING; SECONDARY METABOLISM; TRANSKETOLASE;

EID: 84897464610     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-223     Document Type: Article

References (28)

1. Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D. The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012, 53(3):421-436. 10.1016/j.freeradbiomed.2012.05.006, 22580150.
2. Tong X, Zhao F, Thompson CB. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Curr Opin Genet Dev 2009, 19(1):32-37. 10.1016/j.gde.2009.01.002, 2707261, 19201187.
3. Boros LG, Puigjaner J, Cascante M, Lee W-NP, Brandes JL, Bassilian S, Yusuf FI, Williams RD, Muscarella P, Melvin WS, Schirmer WJ. Oxythiamine and Dehydroepiandrosterone Inhibit the Nonoxidative Synthesis of Ribose and Tumor Cell Proliferation. Cancer Res 1997, 57(19):4242-4248.
4. Coy J, Dressler D, Wilde J, Schubert P. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 2005, 51(5-6):257-273.
5. Langbein S, Zerilli M, Zur Hausen A, Staiger W, Rensch-Boschert K, Lukan N, Popa J, Ternullo MP, Steidler A, Weiss C, Grobholz R, Willeke F, Alken P, Stassi G, Schubert P, Coy JF. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer 2006, 94(4):578-585. 10.1038/sj.bjc.6602962, 2361175, 16465194.
6. Grimm M, Hoefert S, Luz O, Reinert S, Polligkeit J. Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 2013, 116(3):e173-e178. 10.1016/j.oooo.2011.12.022, 22819458.
7. Zerilli M, Amato MC, Martorana A, Cabibi D, Coy JF, Cappello F, Pompei G, Russo A, Giordano C, Rodolico V. Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases. Cancer 2008, 113(5):936-944. 10.1002/cncr.23683, 18615628.
8. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA. TKTL1 Is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1a stabilization. Clin Cancer Res 2010, 16(3):857-866. 10.1158/1078-0432.CCR-09-2604, 2824550, 20103683.
9. Xu X, zur Hausen A, Coy JF, Löchelt M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer 2009, 124(6):1330-1337. 10.1002/ijc.24078, 19065656.
10. Wanka C, Steinbach JP, Rieger J. Tp53-Induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by Up-regulating respiration and improving cellular redox homeostasis. J Biol Chem 2012, 287(40):33436-33446. 10.1074/jbc.M112.384578, 3460445, 22887998.
11. Dzeja P, Terzic A. Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci 2009, 10(4):1729-1772. 10.3390/ijms10041729, 2680645, 19468337.
12. Noma T. Dynamics of nucleotide metabolism as a supporter of life phenomena. J Med Invest 2005, 52(3,4):127-136. 10.2152/jmi.52.127, 16167529.
13. Bruns GA, Regina VM. Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet 1977, 15(5-6):477-486.
14. Köhler C, Gahm A, Noma T, Nakazawa A, Orrenius S, Zhivotovsky B. Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett 1999, 447(1):10-12. 10.1016/S0014-5793(99)00251-3, 10218571.
15. Lagresle-Peyrou C, Six EM, Picard C, Rieux-Laucat F, Michel V, Ditadi A, Demerens-de Chappedelaine C, Morillon E, Valensi F, Simon-Stoos KL, Mullikin JC, Noroski LM, Besse C, Wulffraat NM, Ferster A, Abecasis MM, Calvo F, Petit C, Candotti F, Abel L, Fischer A, Cavazzana-Calvo M. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet 2009, 41(1):106-111. 10.1038/ng.278, 2612090, 19043416.
16. Pannicke U, Hönig M, Hess I, Friesen C, Holzmann K, Rump EM, Barth TF, Rojewski MT, Schulz A, Boehm T, Friedrich W, Schwarz K. Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nat Genet 2009, 41(1):101-105. 10.1038/ng.265, 19043417.
17. Fujisawa K, Murakami R, Horiguchi T, Noma T. Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster. Comp Biochem Physiol B Biochem Mol Biol 2009, 153(1):29-38. 10.1016/j.cbpb.2009.01.006, 19416704.
18. Dzeja PP, Chung S, Faustino RS, Behfar A, Terzic A. Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. PLoS One 2011, 6(4):e19300. 10.1371/journal.pone.0019300, 3083437, 21556322.
19. Barrero CA, Datta PK, Sen S, Deshmane S, Amini S, Khalili K, Merali S. HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. PLoS One 2013, 8(7):e68376. 10.1371/journal.pone.0068376, 3709966, 23874603.
20. Greengard O, Head JF, Goldberg SL. Uridine kinase, adenylate kinase, and guanase in human lung tumors. Cancer Res 1980, 40(7):2295-2299.
21. Nelson BD, Kabir F. Adenylate kinase is a source of ATP for tumor mitochondrial hexokinase. Biochim Biophys Acta Gen Subj 1985, 841(2):195-200.
22. Nakayama S, Sasaki A, Mese H, Alcalde RE, Matsumura T. Establishment of high and Low metastasis cell lines derived from a human tongue squamous cell carcinoma. Invasion Metastasis 1998, 18(5-6):219-228.
23. Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1[alpha]-induced metabolic reprograming. Oncogene 2010, 29(20):2962-2972. 10.1038/onc.2010.67, 2874611, 20228846.
24. Wang W, Guan KL. AMP-activated protein kinase and cancer. Acta Physiol 2009, 196(1):55-63.
25. Carling D, Mayer FV, Sanders MJ, Gamblin SJ. AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol 2011, 7(8):512-518. 10.1038/nchembio.610, 21769098.
26. Carling D, Thornton C, Woods A, Sanders MJ. AMP-activated protein kinase: new regulation, new roles?. Biochem J 2012, 445(1):11-27. 10.1042/BJ20120546, 22702974.
27. Erin E, Mendoza MGP, Kong X, Leeper DB, Caro J, Limesand KH, Burd R. Control of glycolytic flux by AMP-activated protein kinase in tumor cells adapted to Low pH. Transl Oncol 2012, 5(3):208-216. 10.1593/tlo.11319, 3384275, 22741040.
28. Jeon S-M, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012, 485(7400):661-665. 10.1038/nature11066, 3607316, 22660331.