Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 7, 2014, Pages 2311-2319

  Parveen, Zahida ^a,c   Brunhofer, Gerda ^b   Jabeen, Ishrat ^b   Erker, Thomas ^b   Chiba, Peter ^a   Ecker, Gerhard F ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c ABDUL WALI KHAN UNIVERSITY   (Pakistan)

Author keywords

ABCB1; Chalcones; GRIND; MDR; P glycoprotein

Indexed keywords

CHALCONE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; NEW DRUG; PROPAFENONE; CHALCONE;

ARTICLE; CHEMICAL BINDING; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MATHEMATICAL MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897463024     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.005     Document Type: Article

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