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Volumn 24, Issue 7, 2014, Pages 1780-1783
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Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway
a
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Author keywords
Checkpoint; DNA repair; DNA replication; Lung cancer; POLD4; Skp2
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Indexed keywords
PHOSPHATIDYLINOSITOL 3 KINASE;
POLD4 PROTEIN;
PROTEIN;
PROTEIN KINASE B;
PROTEIN P27;
S PHASE KINASE ASSOCIATED PROTEIN 2;
SMALL INTERFERING RNA;
UNCLASSIFIED DRUG;
CYCLIN DEPENDENT KINASE INHIBITOR 1B;
DNA DIRECTED DNA POLYMERASE GAMMA;
DNA POLYMERASE DELTA P12 SUBUNIT, HUMAN;
S PHASE KINASE ASSOCIATED PROTEIN;
CISPLATIN;
DNA DIRECTED DNA POLYMERASE DELTA;
ETOPOSIDE;
FLUOROURACIL;
PROTEIN P21;
PROTEIN POLD4;
ARTICLE;
CELL CYCLE PROGRESSION;
CELL PROLIFERATION;
CELL SURVIVAL;
DNA REPAIR;
DNA REPLICATION;
DOWN REGULATION;
G1 PHASE CELL CYCLE CHECKPOINT;
GENOMIC INSTABILITY;
IN VITRO STUDY;
LUNG CANCER;
PROTEIN EXPRESSION;
PROTEIN PHOSPHORYLATION;
SIGNAL TRANSDUCTION;
UPREGULATION;
ANTAGONISTS AND INHIBITORS;
CELL CYCLE G1 PHASE;
CELL CYCLE S PHASE;
DOSE RESPONSE;
DRUG EFFECTS;
HUMAN;
METABOLISM;
STRUCTURE ACTIVITY RELATION;
TUMOR CELL LINE;
APOPTOSIS;
CALU6 CELL;
CANCER CELL;
CONTROLLED STUDY;
DRUG SENSITIVITY;
ENZYME ACTIVATION;
GENE SILENCING;
LUNG CANCER CELL LINE;
CELL LINE, TUMOR;
CYCLIN-DEPENDENT KINASE INHIBITOR P27;
DNA POLYMERASE III;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DOWN-REGULATION;
G1 PHASE;
HUMANS;
PROTO-ONCOGENE PROTEINS C-AKT;
RNA, SMALL INTERFERING;
S PHASE;
S-PHASE KINASE-ASSOCIATED PROTEINS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84897438803
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2014.02.033 Document Type: Article |
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Times cited : (7)
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References (18)
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