Platelet-rich plasma induces annulus fibrosus cell proliferation and matrix production

European Spine Journal

Volumn 23, Issue 4, 2014, Pages 745-753

  Pirvu, T N ^a   Schroeder, J E ^a,b   Peroglio, M ^a   Verrier, S ^a   Kaplan, L ^b   Richards, R G ^a   Alini, M ^a   Grad, S ^a  

^a AO RESEARCH INSTITUTE   (Switzerland)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Annulus fibrosus; Intervertebral disc; Platelet lysate; Platelet rich plasma; Proteoglycans

Indexed keywords

AGGRECAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; DECORIN; ELASTIN; GLYCOSAMINOGLYCAN; VERSICAN; BIOLOGICAL MARKER; COLLAGEN;

ANIMAL CELL; ANIMAL TISSUE; ANNULUS FIBROSUS; ARTICLE; CARBOHYDRATE SYNTHESIS; CATTLE; CELL CULTURE; CELL LYSATE; CELL PROLIFERATION; CELL STRUCTURE; DNA CONTENT; EXTRACELLULAR MATRIX; GENE EXPRESSION; HISTOLOGY; MONOLAYER CULTURE; NONHUMAN; ORGAN CULTURE; PLATELET LYSATE; PRIORITY JOURNAL; SPINDLE CELL; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTE POOR PLASMA; THROMBOCYTE RICH PLASMA; UPREGULATION; ANIMAL; BOVINAE; COMPARATIVE STUDY; EVALUATION STUDY; FEASIBILITY STUDY; INTERVERTEBRAL DISK; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PROCEDURES; REGENERATION; TISSUE REGENERATION;

ANIMALS; BIOLOGICAL MARKERS; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; EXTRACELLULAR MATRIX; FEASIBILITY STUDIES; GLYCOSAMINOGLYCANS; GUIDED TISSUE REGENERATION; INTERVERTEBRAL DISC; ORGAN CULTURE TECHNIQUES; PLATELET-RICH PLASMA; REGENERATION;

EID: 84897425570     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-014-3198-x     Document Type: Article

References (47)

1. Videman T, Nurminen M (2004) The occurrence of annular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine (Phila Pa 1976) 29:2668-2676
2. Loreto C, Musumeci G, Castorina A, Loreto C, Martinez G (2011) Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death. Ann Anat 193:156-162
3. Guterl CC, See EY, Blanquer SB, Pandit A, Ferguson SJ, Benneker LM, Grijpma DW, Sakai D, Eglin D, Alini M, Iatridis JC, Grad S (2013) Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cell Mater 25:1-21
4. Masuda K (2008) Biological repair of the degenerated intervertebral disc by the injection of growth factors. Eur Spine J 17(Suppl 4):441-451
5. Gilbertson L, Ahn SH, Teng PN, Studer RK, Niyibizi C, Kang JD (2008) The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells. Spine J 8:449-456 (Pubitemid 351608960)
6. Kim H, Lee JU, Moon SH, Kim HC, Kwon UH, Seol NH, Kim HJ, Park JO, Chun HJ, Kwon IK, Lee HM (2009) Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. Spine (Phila Pa 1976) 34:1834-1838
7. Takegami K, An HS, Kumano F, Chiba K, Thonar EJ, Singh K, Masuda K (2005) Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis. Spine J 5:231-238 (Pubitemid 40613662)
8. Gruber HE, Fisher EC Jr, Desai B, Stasky AA, Hoelscher G, Hanley EN Jr (1997) Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res 235:13-21 (Pubitemid 27381676)
9. Hegewald AA, Zouhair S, Endres M, Cabraja M, Woiciechowsky C, Thome C, Kaps C (2013) Towards biological annulus repair: TGF-beta3, FGF-2 and human serum support matrix formation by human annulus fibrosus cells. Tissue Cell 45:68-76
10. Akeda K, An HS, Pichika R, Attawia M, Thonar EJ, Lenz ME, Uchida A, Masuda K (2006) Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and annulus fibrosus cells cultured in alginate beads. Spine (Phila Pa 1976) 31:959-966
11. Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP (2009) Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma. Biomaterials 30:5523-5533
12. Obata S, Akeda K, Imanishi T, Masuda K, Bae W, Morimoto R, Asanuma Y, Kasai Y, Uchida A, Sudo A (2012) Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit annular puncture model: a preclinical study. Arthritis Res Ther 14:R241
13. Nagae M, Ikeda T, Mikami Y, Hase H, Ozawa H, Matsuda K, Sakamoto H, Tabata Y, Kawata M, Kubo T (2007) Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres. Tissue Eng 13:147-158 (Pubitemid 46175536)
14. Sawamura K, Ikeda T, Nagae M, Okamoto S, Mikami Y, Hase H, Ikoma K, Yamada T, Sakamoto H, Matsuda K, Tabata Y, Kawata M, Kubo T (2009) Characterization of in vivo effects of plateletrich plasma and biodegradable gelatin hydrogel microspheres on degenerated intervertebral discs. Tissue Eng Part A 15:3719-3727
15. Alsousou J, Thompson M, Hulley P, Noble A, Willett K (2009) The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br 91:987-996
16. Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH (2010) The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 26:269-278
17. Paoloni J, De Vos RJ, Hamilton B, Murrell GA, Orchard J (2011) Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med 21:37-45
18. Cieslik-Bielecka A, Choukroun J, Odin G, Dohan Ehrenfest DM (2012) L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds. Curr Pharm Biotechnol 13:1266-1277
19. Verrier S, Meury TR, Kupcsik L, Heini P, Stoll T, Alini M (2010) Platelet-released supernatant induces osteoblastic differentiation of human mesenchymal stem cells: potential role of BMP-2. Eur Cell Mater 20:403-414
20. Lippross S, Loibl M, Hoppe S, Meury T, Benneker L, Alini M, Verrier S (2011) Platelet released growth factors boost expansion of bone marrow derived CD34(+) and CD133(+) endothelial progenitor cells for autologous grafting. Platelets 22:422-432
21. Rauch C, Feifel E, Amann EM, Spotl HP, Schennach H, Pfaller W, Gstraunthaler G (2011) Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media. ALTEX 28:305-316
22. Gruber HE, Norton HJ, Hanley EN Jr (2000) Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine (Phila Pa 1976) 25:2153-2157
23. Zhao CQ, Liu D, Li H, Jiang LS, Dai LY (2007) Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis. Apoptosis 12:2155-2161 (Pubitemid 350077251)
24. Illien-Junger S, Pattappa G, Peroglio M, Benneker LM, Stoddart MJ, Sakai D, Mochida J, Grad S, Alini M (2012) Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system. Spine (Phila Pa 1976) 37:1865-1873
25. Melrose J, Ghosh P, Taylor TK (2001) A comparative analysis of the differential spatial and temporal distributions of the large (aggrecan, versican) and small (decorin, biglycan, fibromodulin) proteoglycans of the intervertebral disc. J Anat 198:3-15 (Pubitemid 32162312)
26. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM (2008) Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg 66:684-690 (Pubitemid 351381788)
27. DeLong JM, Russell RP, Mazzocca AD (2012) Platelet-rich plasma: the PAW classification system. Arthroscopy 28:998-1009
28. Chou AI, Reza AT, Nicoll SB (2008) Distinct intervertebral disc cell populations adopt similar phenotypes in three-dimensional culture. Tissue Eng Part A 14:2079-2087
29. de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA, van Osch GJ (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36:1171-1178 (Pubitemid 351713047)
30. Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo KS, Fortier LA (2007) Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 25:230-240 (Pubitemid 46344249)
31. Cabraja M, Endres M, Hegewald AA, Vetterlein S, Thome C, Woiciechowsky C, Kaps C (2012) A 3D environment for annulus fibrosus regeneration. J Neurosurg Spine 17:177-183
32. Veres SP, Robertson PA, Broom ND (2008) ISSLS prize winner: microstructure and mechanical disruption of the lumbar disc annulus: part II: how the annulus fails under hydrostatic pressure. Spine (Phila Pa 1976) 33:2711-2720
33. Ahlgren BD, Lui W, Herkowitz HN, Panjabi MM, Guiboux JP (2000) Effect of annular repair on the healing strength of the intervertebral disc: a sheep model. Spine (Phila Pa 1976) 25:2165-2170
34. Heuer F, Ulrich S, Claes L, Wilke HJ (2008) Biomechanical evaluation of conventional annulus fibrosus closure methods required for nucleus replacement. Laboratory investigation. J Neurosurg Spine 9:307-313
35. Bron JL, van der Veen AJ, Helder MN, van Royen BJ, Smit TH (2010) Biomechanical and in vivo evaluation of experimental closure devices of the annulus fibrosus designed for a goat nucleus replacement model. Eur Spine J 19:1347-1355
36. Wismer N, Grad S, Fortunato G, Ferguson SJ, Alini M, Eglin D (2013) Biodegradable electrospun scaffolds for annulus fibrosus tissue engineering: effect of scaffold structure and composition on annulus fibrosus cells in vitro. Tissue Eng Part A
37. Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL (2009) Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat Mater 8:986-992
38. Bron JL, Helder MN, Meisel HJ, van Royen BJ, Smit TH (2009) Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges. Eur Spine J 18:301-313
39. Graziani F, Ivanovski S, Cei S, Ducci F, Tonetti M, Gabriele M (2006) The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 17:212-219 (Pubitemid 43374309)
40. Duttenhoefer F, de Lara FR, Meury T, Loibl M, Benneker LM, Richards RG, Alini M, Verrier S (2013) 3D scaffolds co-seeded with human endothelial progenitor and mesenchymal stem cells: evidence of prevascularisation within 7 days. Eur Cell Mater 26:49-64
41. Illien-Junger S, Gantenbein-Ritter B, Grad S, Lezuo P, Ferguson SJ, Alini M, Ito K (2010) The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates. Spine (Phila Pa 1976) 35:1744-1752
42. Ledet EH, Jeshuran W, Glennon JC, Shaffrey C, De DP, Belden C, Kallakury B, Carl AL (2009) Small intestinal submucosa for annular defect closure: long-term response in an in vivo sheep model. Spine (Phila Pa 1976) 34:1457-1463
43. Osti OL, Vernon-Roberts B, Fraser RD (1990) 1990 Volvo Award in experimental studies. Annulus tears and intervertebral disc degeneration. An experimental study using an animal model. Spine (Phila Pa 1976) 15:762-767
44. Melrose J, Smith SM, Little CB, Moore RJ, Vernon-Roberts B, Fraser RD (2008) Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. Eur Spine J 17:1131-1148
45. Wang YH, Kuo TF, Wang JL (2007) The implantation of non-cell-based materials to prevent the recurrent disc herniation: an in vivo porcine model using quantitative discomanometry examination. Eur Spine J 16:1021-1027
46. Yoon SH, Miyazaki M, Hong SW, Tow B, Morishita Y, Hu M, Ahn SJ, Wang JC (2008) A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. J Neurosurg Spine 8:450-457 (Pubitemid 351792087)
47. Zhang Y, Drapeau S, An HS, Markova D, Lenart BA, Anderson DG (2011) Histological features of the degenerating intervertebral disc in a goat disc-injury model. Spine (Phila Pa 1976) 36:1519-1527