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Volumn 20, Issue , 2010, Pages 403-414

Platelet-released supernatant induces osteoblastic differentiation of human mesenchymal stem cells: Potential role of BMP-2

Author keywords

Differentiation; Growth factors; Mesenchymal stem cells; Osteoblast; Platelets

Indexed keywords

BIOLOGICAL FACTOR; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; CALCIUM;

EID: 79953108520     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v020a33     Document Type: Article
Times cited : (36)

References (55)
  • 2
    • 0028222514 scopus 로고
    • Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: Arrest of type X collagen synthesis and net loss of collagen when calcification is initiated
    • Alini M., Carey D, Hirata S, Grynpas MD, Pidoux I, Poole A. R (1994) Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: arrest of type X collagen synthesis and net loss of collagen when calcification is initiated. J Bone Miner Res 9: 1077-1087.
    • (1994) J Bone Miner Res , vol.9 , pp. 1077-1087
    • Alini, M.1    Carey, D.2    Hirata, S.3    Grynpas, M.D.4    Pidoux, I.5    Poole, A.R.6
  • 3
    • 0004473225 scopus 로고    scopus 로고
    • The cellular cascades of wound healing
    • In, (Davies JE, ed). em squared inc, Toronto, Ont, Canada
    • Anderson J. M (1999) The cellular cascades of wound healing. In: Bone Engineering (Davies JE, ed). em squared inc, Toronto, Ont, Canada, pp 81-93.
    • (1999) Bone Engineering , pp. 81-93
    • Anderson, J.M.1
  • 4
    • 1642475081 scopus 로고    scopus 로고
    • Autologous platelets as a source of proteins for healing and tissue regeneration
    • Anitua E., Andia I, Ardanza B, Nurden P, Nurden AT (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91: 4-15.
    • (2004) Thromb Haemost , vol.91 , pp. 4-15
    • Anitua, E.1    Andia, I.2    Ardanza, B.3    Nurden, P.4    Nurden, A.T.5
  • 5
    • 0345768562 scopus 로고    scopus 로고
    • Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study
    • Arpornmaeklong P., Kochel M, Depprich R, Kubler NR, Wurzler K. K (2004) Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. Int J Oral Maxillofac Surg 33: 60-70.
    • (2004) Int J Oral Maxillofac Surg , vol.33 , pp. 60-70
    • Arpornmaeklong, P.1    Kochel, M.2    Depprich, R.3    Kubler, N.R.4    Wurzler, K.K.5
  • 7
    • 0026322345 scopus 로고
    • The immunology of bone and cartilage transplantation
    • Bolano L., Kopta JA (1991) The immunology of bone and cartilage transplantation. Orthopedics 14: 987-996.
    • (1991) Orthopedics , vol.14 , pp. 987-996
    • Bolano, L.1    Kopta, J.A.2
  • 8
    • 33744460788 scopus 로고    scopus 로고
    • Bone grafts prepared with selective cell retention technology heal canine segmental defects as effectively as autograft
    • Brodke D., Pedrozo HA, Kapur TA, Attawia M, Kraus KH, Holy CE, Kadiyala S, Bruder SP (2006) Bone grafts prepared with selective cell retention technology heal canine segmental defects as effectively as autograft. J Orthop Res 24: 857-866.
    • (2006) J Orthop Res , vol.24 , pp. 857-866
    • Brodke, D.1    Pedrozo, H.A.2    Kapur, T.A.3    Attawia, M.4    Kraus, K.H.5    Holy, C.E.6    Kadiyala, S.7    Bruder, S.P.8
  • 9
    • 0031059353 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
    • Chen D., Harris MA, Rossini G, Dunstan CR, Dallas SL, Feng JQ, Mundy GR, Harris SE (1997) Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int 60: 283-290.
    • (1997) Calcif Tissue Int , vol.60 , pp. 283-290
    • Chen, D.1    Harris, M.A.2    Rossini, G.3    Dunstan, C.R.4    Dallas, S.L.5    Feng, J.Q.6    Mundy, G.R.7    Harris, S.E.8
  • 10
    • 0022645259 scopus 로고
    • The effects of 1,25-dihydroxyvitamin D3 and dexamethasone on rat osteoblast-like primary cell cultures: Receptor occupancy and functional expression patterns for three different bioresponses
    • Chen T. L, Hauschka PV, Cabrales S, Feldman D (1986) The effects of 1,25-dihydroxyvitamin D3 and dexamethasone on rat osteoblast-like primary cell cultures: receptor occupancy and functional expression patterns for three different bioresponses. Endocrinology 118: 250-259.
    • (1986) Endocrinology , vol.118 , pp. 250-259
    • Chen, T.L.1    Hauschka, P.V.2    Cabrales, S.3    Feldman, D.4
  • 11
    • 0028009219 scopus 로고
    • Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone
    • Cheng S. L, Yang JW, Rifas L, Zhang SF, Avioli LV (1994) Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone. Endocrinology 134: 277-286.
    • (1994) Endocrinology , vol.134 , pp. 277-286
    • Cheng, S.L.1    Yang, J.W.2    Rifas, L.3    Zhang, S.F.4    Avioli, L.V.5
  • 12
    • 0029993542 scopus 로고    scopus 로고
    • Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells
    • Cheng S. L, Zhang SF, Avioli LV (1996) Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells. J Cell Biochem 61: 182-193.
    • (1996) J Cell Biochem , vol.61 , pp. 182-193
    • Cheng, S.L.1    Zhang, S.F.2    Avioli, L.V.3
  • 13
    • 18244381515 scopus 로고    scopus 로고
    • Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: An in vitro study
    • Choi B. H, Zhu SJ, Kim BY, Huh JY, Lee SH, Jung JH (2005) Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. Int J Oral Maxillofac Surg 34: 420-424.
    • (2005) Int J Oral Maxillofac Surg , vol.34 , pp. 420-424
    • Choi, B.H.1    Zhu, S.J.2    Kim, B.Y.3    Huh, J.Y.4    Lee, S.H.5    Jung, J.H.6
  • 14
    • 4043086277 scopus 로고    scopus 로고
    • Sensitivity of bone to glucocorticoids
    • Cooper M. S (2004) Sensitivity of bone to glucocorticoids. Clin Sci (Lond) 107: 111-123.
    • (2004) Clin Sci (Lond) , vol.107 , pp. 111-123
    • Cooper, M.S.1
  • 15
    • 0032716911 scopus 로고    scopus 로고
    • Glucocorticoid activity, inactivity and the osteoblast
    • Cooper M. S, Hewison M, Stewart PM (1999) Glucocorticoid activity, inactivity and the osteoblast. J Endocrinol 163: 159-164.
    • (1999) J Endocrinol , vol.163 , pp. 159-164
    • Cooper, M.S.1    Hewison, M.2    Stewart, P.M.3
  • 18
    • 0036256889 scopus 로고    scopus 로고
    • Platelet-released supernatants stimulate formation of osteoclast-like cells through a prostaglandin/ RANKLdependent mechanism
    • Gruber R., Karreth F, Fischer MB, Watzek G (2002a) Platelet-released supernatants stimulate formation of osteoclast-like cells through a prostaglandin/ RANKLdependent mechanism. Bone 30: 726-732.
    • (2002) Bone , vol.30 , pp. 726-732
    • Gruber, R.1    Karreth, F.2    Fischer, M.B.3    Watzek, G.4
  • 19
    • 0036780996 scopus 로고    scopus 로고
    • Platelets stimulate proliferation of bone cells: Involvement of platelet-derived growth factor, microparticles and membranes
    • Gruber R., Varga F, Fischer MB, Watzek G (2002b) Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clin Oral Implants Res 13: 529-535.
    • (2002) Clin Oral Implants Res , vol.13 , pp. 529-535
    • Gruber, R.1    Varga, F.2    Fischer, M.B.3    Watzek, G.4
  • 21
    • 16544367170 scopus 로고    scopus 로고
    • Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    • Igarashi M., Kamiya N, Hasegawa M, Kasuya T, Takahashi T., Takagi M (2004) Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts. J Mol Histol 35: 3-10.
    • (2004) J Mol Histol , vol.35 , pp. 3-10
    • Igarashi, M.1    Kamiya, N.2    Hasegawa, M.3    Kasuya, T.4    Takahashi, T.5    Takagi, M.6
  • 22
    • 0242655673 scopus 로고    scopus 로고
    • Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
    • Jimenez M. J, Balbin M, Lopez JM, Alvarez J, Komori T, Lopez-Otin C (1999) Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19: 4431-4442.
    • (1999) Mol Cell Biol , vol.19 , pp. 4431-4442
    • Jimenez, M.J.1    Balbin, M.2    Lopez, J.M.3    Alvarez, J.4    Komori, T.5    Lopez-Otin, C.6
  • 23
    • 2942534119 scopus 로고    scopus 로고
    • Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: Validation of an in vitro model for human bone marrow-derived primary osteoblasts
    • Jorgensen N. R, Henriksen Z, Sorensen OH, Civitelli R (2004) Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts. Steroids 69: 219-226.
    • (2004) Steroids , vol.69 , pp. 219-226
    • Jorgensen, N.R.1    Henriksen, Z.2    Sorensen, O.H.3    Civitelli, R.4
  • 24
    • 24944522947 scopus 로고    scopus 로고
    • New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite
    • Kilian O., Alt V, Heiss C, Jonuleit T, Dingeldein E, Flesch I., Fidorra U, Wenisch S, Schnettler R (2005) New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite. Growth Factors 23: 125-133.
    • (2005) Growth Factors , vol.23 , pp. 125-133
    • Kilian, O.1    Alt, V.2    Heiss, C.3    Jonuleit, T.4    Dingeldein, E.5    Flesch, I.6    Fidorra, U.7    Wenisch, S.8    Schnettler, R.9
  • 25
    • 49349107314 scopus 로고    scopus 로고
    • In vitro response of primary human bone marrow stromal cells to recombinant human bone morphogenic protein-2 in the early and late stages of osteoblast differentiation
    • Kim I. S, Song YM, Cho TH, Park YD, Lee KB, Noh I, Weber F., Hwang SJ (2008) In vitro response of primary human bone marrow stromal cells to recombinant human bone morphogenic protein-2 in the early and late stages of osteoblast differentiation. Dev Growth Differ 50: 553-564.
    • (2008) Dev Growth Differ , vol.50 , pp. 553-564
    • Kim, I.S.1    Song, Y.M.2    Cho, T.H.3    Park, Y.D.4    Lee, K.B.5    Noh, I.6    Weber, F.7    Hwang, S.J.8
  • 26
    • 5344274555 scopus 로고    scopus 로고
    • Transplantation of marrow-derived mesenchymal stem cells and plateletrich plasma during distraction osteogenesis-a preliminary result of three cases
    • Kitoh H., Kitakoji T, Tsuchiya H, Mitsuyama H, Nakamura H., Katoh M, Ishiguro N (2004) Transplantation of marrow-derived mesenchymal stem cells and plateletrich plasma during distraction osteogenesis-a preliminary result of three cases. Bone 35: 892-898.
    • (2004) Bone , vol.35 , pp. 892-898
    • Kitoh, H.1    Kitakoji, T.2    Tsuchiya, H.3    Mitsuyama, H.4    Nakamura, H.5    Katoh, M.6    Ishiguro, N.7
  • 27
    • 0026043850 scopus 로고
    • Cytoskeleton-dependent release of human platelet epidermal growth factor
    • Kiuru J., Viinikka L, Myllyla G, Pesonen K, Perheentupa J (1991) Cytoskeleton-dependent release of human platelet epidermal growth factor. Life Sci 49: 1997-2003.
    • (1991) Life Sci , vol.49 , pp. 1997-2003
    • Kiuru, J.1    Viinikka, L.2    Myllyla, G.3    Pesonen, K.4    Perheentupa, J.5
  • 29
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee K. S, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney J. M, Kim EG, Choi JY, Ryoo HM, Bae SC (2000) Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20: 8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10    Bae, S.C.11
  • 30
    • 34047129218 scopus 로고    scopus 로고
    • Controlled release of PRP-derived growth factors promotes osteogenic differentiation of human mesenchymal stem cells
    • Lin S. S, Landesberg R, Chin HS, Lin J, Eisig SB, Lu HH (2006) Controlled release of PRP-derived growth factors promotes osteogenic differentiation of human mesenchymal stem cells. Conf Proc IEEE Eng Med Biol Soc 1: 4358-4361.
    • (2006) Conf Proc IEEE Eng Med Biol Soc , vol.1 , pp. 4358-4361
    • Lin, S.S.1    Landesberg, R.2    Chin, H.S.3    Lin, J.4    Eisig, S.B.5    Lu, H.H.6
  • 31
    • 0032802360 scopus 로고    scopus 로고
    • Use of autologous growth factors in lumbar spinal fusion
    • Lowery G. L, Kulkarni S, Pennisi AE (1999) Use of autologous growth factors in lumbar spinal fusion. Bone 25: 47S-50S.
    • (1999) Bone , vol.25
    • Lowery, G.L.1    Kulkarni, S.2    Pennisi, A.E.3
  • 34
    • 0030885841 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow
    • Martin I., Muraglia A, Campanile G, Cancedda R, Quarto R. (1997) Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138: 4456-4462.
    • (1997) Endocrinology , vol.138 , pp. 4456-4462
    • Martin, I.1    Muraglia, A.2    Campanile, G.3    Cancedda, R.4    Quarto, R.5
  • 37
    • 0022534094 scopus 로고
    • Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue culture
    • McCulloch CA, Tenenbaum HC (1986) Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue culture. Anat Rec 215: 397-402.
    • (1986) Anat Rec , vol.215 , pp. 397-402
    • McCulloch, C.A.1    Tenenbaum, H.C.2
  • 38
    • 33745618179 scopus 로고    scopus 로고
    • Human endothelial cells inhibit BMSC differentiation into mature osteoblasts in vitro by interfering with osterix expression
    • Meury T., Verrier S, Alini M (2006) Human endothelial cells inhibit BMSC differentiation into mature osteoblasts in vitro by interfering with osterix expression. J Cell Biochem 98: 992-1006.
    • (2006) J Cell Biochem , vol.98 , pp. 992-1006
    • Meury, T.1    Verrier, S.2    Alini, M.3
  • 41
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K., Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer R. R, de Crombrugghe B (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    de Crombrugghe, B.7
  • 43
    • 23044506069 scopus 로고    scopus 로고
    • Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signalregulated kinase and phosphatidylinositol 3-kinase signaling
    • Osyczka A. M, Leboy PS (2005) Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signalregulated kinase and phosphatidylinositol 3-kinase signaling. Endocrinology 146: 3428-3437.
    • (2005) Endocrinology , vol.146 , pp. 3428-3437
    • Osyczka, A.M.1    Leboy, P.S.2
  • 44
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi G., Vayssiere B, Dunn F, Baron R, Roman-Roman S. (2003) BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 18: 1842-1853.
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 45
    • 0942268151 scopus 로고    scopus 로고
    • Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7
    • Roldan J. C, Jepsen S, Miller J, Freitag S, Rueger DC, Acil Y., Terheyden H (2004) Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone 34: 80-90.
    • (2004) Bone , vol.34 , pp. 80-90
    • Roldan, J.C.1    Jepsen, S.2    Miller, J.3    Freitag, S.4    Rueger, D.C.5    Acil, Y.6    Terheyden, H.7
  • 48
    • 0036325209 scopus 로고    scopus 로고
    • Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count
    • Weibrich G., Kleis WK, Hafner G, Hitzler WE (2002) Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Craniomaxillofac Surg 30: 97-102.
    • (2002) J Craniomaxillofac Surg , vol.30 , pp. 97-102
    • Weibrich, G.1    Kleis, W.K.2    Hafner, G.3    Hitzler, W.E.4
  • 49
    • 0030666361 scopus 로고    scopus 로고
    • Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery
    • Whitman D. H, Berry RL, Green DM (1997) Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 55: 1294-1299.
    • (1997) J Oral Maxillofac Surg , vol.55 , pp. 1294-1299
    • Whitman, D.H.1    Berry, R.L.2    Green, D.M.3
  • 50
    • 0031974284 scopus 로고    scopus 로고
    • Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
    • Wozney J. M, Rosen V (1998) Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res (346): 26-37.
    • (1998) Clin Orthop Relat Res , Issue.346 , pp. 26-37
    • Wozney, J.M.1    Rosen, V.2
  • 51
    • 4444265779 scopus 로고    scopus 로고
    • Translational research for injectable tissue-engineered bone regeneration using mesenchymal stem cells and plateletrich plasma: From basic research to clinical case study
    • Yamada Y., Ueda M, Hibi H, Nagasaka T (2004a) Translational research for injectable tissue-engineered bone regeneration using mesenchymal stem cells and plateletrich plasma: from basic research to clinical case study. Cell Transplant 13: 343-355.
    • (2004) Cell Transplant , vol.13 , pp. 343-355
    • Yamada, Y.1    Ueda, M.2    Hibi, H.3    Nagasaka, T.4
  • 52
    • 3042771201 scopus 로고    scopus 로고
    • Autogenous injectable bone for regeneration with mesenchymal stem cells and plateletrich plasma: Tissue-engineered bone regeneration
    • Yamada Y., Ueda M, Naiki T, Takahashi M, Hata K, Nagasaka T. (2004b) Autogenous injectable bone for regeneration with mesenchymal stem cells and plateletrich plasma: tissue-engineered bone regeneration. Tissue Eng 10: 955-964.
    • (2004) Tissue Eng , vol.10 , pp. 955-964
    • Yamada, Y.1    Ueda, M.2    Naiki, T.3    Takahashi, M.4    Hata, K.5    Nagasaka, T.6
  • 53
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • Yamaguchi A., Komori T, Suda T (2000) Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 21: 393-411.
    • (2000) Endocr Rev , vol.21 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 54
    • 33747318207 scopus 로고    scopus 로고
    • Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro?
    • Zhou Y. S, Liu YS, Tan JG (2006) Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro? Chin Med J. (Engl) 119: 1278-1286.
    • (2006) Chin Med J. (Engl) , vol.119 , pp. 1278-1286
    • Zhou, Y.S.1    Liu, Y.S.2    Tan, J.G.3
  • 55
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman L. B, Jesus-Escobar JM, Harland RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86: 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    Jesus-Escobar, J.M.2    Harland, R.M.3


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