High fat diet and GLP-1 drugs induce pancreatic injury in mice

Toxicology and Applied Pharmacology

Volumn 276, Issue 2, 2014, Pages 104-114

  Rouse, Rodney ^a   Xu, Lin ^a   Stewart, Sharron ^a   Zhang, Jun ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Acinar cell death; Drug induced pancreatitis; High fat diet; Macrophage activation; Pancreatic vasculitis; Pro inflammatory cytokines

Indexed keywords

CYTOKINE; EXENDIN 4; GLUCOSE; INTERLEUKIN 1BETA; KERATINOCYTE CHEMO ATTRACTANT; SITAGLIPTIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACINAR CELL; ACINAR CELL APOPTOSIS; ACINAR CELL ATROPHY; ACINAR CELL AUTOPHAGY; ACINAR CELL HYPERTROPHY; ACINAR CELL NECROSIS; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; AUTOPHAGY; BLOOD VESSEL INJURY; BODY WEIGHT; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFECT; EDEMA; FAT NECROSIS; FEEDING; GLUCOSE BLOOD LEVEL; HYPERTROPHY; INFLAMMATION; INSULIN RESISTANCE; INTERSTITIAL EDEMA; KERATINOCYTE; LIPID DIET; MALE; MOUSE; MOUSE MODEL; NECROSIS; NONHUMAN; PANCREAS INJURY; RISK FACTOR;

ACINAR CELL DEATH; DRUG-INDUCED PANCREATITIS; HIGH FAT DIET; MACROPHAGE ACTIVATION; PANCREATIC VASCULITIS; PRO-INFLAMMATORY CYTOKINES;

ACUTE DISEASE; ANIMALS; APOPTOSIS; ATROPHY; DIET, HIGH-FAT; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; NECROSIS; PANCREAS; PANCREATITIS; PEPTIDES; PYRAZINES; RECEPTORS, GLUCAGON; TRIAZOLES; VENOMS;

EID: 84897424373     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.01.021     Document Type: Article

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