Quantification of the 2-deoxyribonolactone and nucleoside 5′-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: Differential effects of γ-radiation and Fe2+-EDTA

Journal of the American Chemical Society

Volumn 132, Issue 17, 2010, Pages 6145-6153

  Chan, Wan ^a   Chen, Bingzi ^a   Wang, Lianrong ^a   Taghizadeh, Koli ^a   Demott, Michael S ^a   Dedon, Peter C ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2(5H)-FURANONE; 2-DEOXYRIBONOLACTONE; ANALYTICAL DATA; BACKGROUND LEVEL; CALICHEAMICIN; CELLULAR ENVIRONMENT; CELLULAR TOXICITIES; COUPLED MASS; CRITICAL DETERMINANT; DERIVATIZATIONS; DIFFERENTIAL EFFECT; DNA ISOLATION; DNA OXIDATION; ENEDIYNES; G-VALUES; GC-MS ANALYSIS; HYDROXYL RADICALS; IN-CONTROL; INTERNAL STANDARDS; ISOTOPE DILUTIONS; ISOTOPICALLY LABELED; LOW LEVEL; LYMPHOBLASTOID CELLS; OLIGODEOXYNUCLEOTIDES; OXIDATION CHEMISTRY; OXIDATION PRODUCTS; OXIDATIVE DAMAGE; QUENCHING EFFECT; SOLVENT EXPOSURE; UNIQUE SPECTRA;

ALDEHYDES; BIOMOLECULES; DNA; GAS CHROMATOGRAPHY; GENES; ISOTOPES; MASS SPECTROMETRY; METAL ANALYSIS; RADIATION EFFECTS;

OXIDATION;

2 DEOXYRIBONOLACTONE; 2 DEOXYRIBOSE; CALICHEAMICIN GAMMA1; DNA; EDETIC ACID; FERROUS ION; FURFURAL; HYDRAZINE DERIVATIVE; HYDROXYL RADICAL; LACTONE DERIVATIVE; NUCLEOSIDE 5' ALDEHYDE; NUCLEOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE; PENTAFLUOROPHENYLHYDRAZINE; PROTOANEMONIN; SOLVENT; UNCLASSIFIED DRUG; ZINOSTATIN;

ACCURACY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DERIVATIZATION; DNA ISOLATION; DNA PURIFICATION; GAMMA RADIATION; HUMAN; HUMAN CELL; ISOTOPE DILUTION ASSAY; ISOTOPE LABELING; LYMPHOBLASTOID CELL; MASS FRAGMENTOGRAPHY; OXIDATION KINETICS; RADIATION DOSE;

ALDEHYDES; CELL LINE, TUMOR; DEOXYRIBOSE; DNA; DNA DAMAGE; EDETIC ACID; FERROUS COMPOUNDS; GAMMA RAYS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; NUCLEOSIDES; OXIDATION-REDUCTION; SUGAR ACIDS;

EID: 77951681277     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja910928n     Document Type: Article

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