8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site

DNA Repair

Volumn 3, Issue 3, 2004, Pages 289-299

  Lomax, Martine E ^a   Cunniffe, Siobhan ^a   O'Neill, Peter ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

8 OxoG; Base excision repair; Clustered DNA damage; Single strand breaks

Indexed keywords

8 HYDROXYGUANINE; DOUBLE STRANDED DNA; OLIGONUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN; PROTEIN XRCC1; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EXCISION REPAIR; GENE CLUSTER; GENE MUTATION; PRIORITY JOURNAL;

EID: 0842303306     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2003.11.006     Document Type: Article

References (37)

1. Committee on Health Risks of Exposure to Radon BEIR IV, Effects of Exposure to Radon, National Academy Press, Washington, DC, 1999.
2. Goodhead D.T. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 65:1994;7-17.
3. Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucleic Acid Res. Mol. Biol. 35:1988;95-125.
4. Nikjoo H., O'Neill P., Terrissol M., Goodhead D.T. Quantitative modelling of DNA damage using Monte Carlo track structure method. Radiat. Environ. Biophys. 38:1999;31-38.
5. Nikjoo H., O'Neill P., Wilson W.E., Goodhead D.T. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat. Res. 156:2001;577-583.
6. Sutherland B.M., Bennett P.V., Sidorkina O., Laval J. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc. Natl. Acad. Sci. U.S.A. 97:2000;103-108.
7. Gulston M., Fulford J., Jenner T., de Lara C., O'Neill P. Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res. 30:2002;3464-3472.
8. Sutherland B.M., Bennett P.V., Sutherland J.C., Laval J. Clustered DNA damages induced by X-rays in human cells. Radiat. Res. 157:2002;611-616.
9. Weinfeld M., Rasouli-Nia A., Chaudhry M.A., Britten R.A. Response of base excision repair enzymes to complex DNA lesions. Radiat. Res. 156:2001;584-589.
10. Lomax M., Gulston M., O'Neill P. Chemical aspects of clustered DNA damage induction by ionising radiation. Radiat. Prot. Dosimetry. 99:2002;63-68.
11. Wallace S.S. Biological consequences of free radical-damaged DNA bases. Free Radic. Biol. Med. 33:2002;1-14.
12. David-Cordonnier M.H., Boiteux S., O'Neill P. Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein. Biochemistry. 40:2001;11811-11818.
13. David-Cordonnier M.H., Laval J., O'Neill P. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. J. Biol. Chem. 275:2000;11865-11873.
14. Harrison L., Hatahet Z., Wallace S.S. In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites. J. Mol. Biol. 290:1999;667-684.
15. Nilsen H., Krokan H.E. Base excision repair in a network of defence and tolerance. Carcinogenesis. 22:2001;987-998.
16. Singhal R.K., Prasad R., Wilson S.H. DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem. 270:1995;949-957.
17. Tomkinson A.E., Chen L., Dong Z., Leppard J.B., Levin D.S., Mackey Z.B., Motycka T.A. Completion of base excision repair by mammalian DNA ligases. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;151-164.
18. Matsumoto Y., Kim K., Hurwitz J., Gary R., Levin D.S., Tomkinson A.E., Park M.S. Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins. J. Biol. Chem. 274:1999;33703-33708.
19. Pascucci B., Stucki M., Jonsson Z.O., Dogliotti E., Hubscher U. Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon. J. Biol. Chem. 274:1999;33696-33702.
20. Dianov G.L., Prasad R., Wilson S.H., Bohr V.A. Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J. Biol. Chem. 274:1999;13741-13743.
21. Klungland A., Lindahl T. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). EMBO J. 16:1997;3341-3348.
22. Malyarchuk S., Youngblood R., Landry A.M., Quillin E., Harrison L. The mutation frequency of 8-oxo-7,8-dihydroguanine (8-oxodG) situated in a multiply damaged site: comparison of a single and two closely opposed 8-oxodG in Escherichia coli. DNA Repair Amst. 2:2003;695-705.
23. C.G. Pearson, N. Shikazono, J. Thacker, P. O'Neill, Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site, Nucleic Acids Res, 32 (2004).
24. David-Cordonnier M.H., Cunniffe S.M., Hickson I.D., O'Neill P. Efficiency of incision of an AP site within clustered DNA damage by the major human AP endonuclease. Biochemistry. 41:2002;634-642.
25. David-Cordonnier M.H., Boiteux S., O'Neill P. Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein. Nucleic Acids Res. 29:2001;1107-1113.
26. Errami A., Smider V., Rathmell W.K., He D.M., Hendrickson E.A., Zdzienicka M.Z., Chu G. Ku86 defines the genetic defect and restores X-ray resistance and V(D) J recombination to complementation group 5 hamster cell mutants. Mol. Cell Biol. 16:1996;1519-1526.
27. Calsou P., Frit P., Salles B. Double strand breaks in DNA inhibit nucleotide excision repair in vitro. J. Biol. Chem. 271:1996;27601-27607.
28. Hashimoto M., Donald C.D., Yannone S.M., Chen D.J., Roy R., Kow Y.W. A possible role of Ku in mediating sequential repair of closely opposed lesions. J. Biol. Chem. 276:2001;12827-12831.
29. Budworth H., Dianov G.L. Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions. J. Biol. Chem. 278:2003;9378-9381.
30. David-Cordonnier M.H., Laval J., O'Neill P. Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth. Biochemistry. 40:2001;5738-5746.
31. Budworth H., Dianova I.I., Podust V.N., Dianov G.L. Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair by 8-oxoguanine. J Biol. Chem. 277:2002;21300-21305.
32. Matsumoto Y., Kim K. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science. 269:1995;699-702.
33. Ferguson D.O., Alt F.W. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene. 20:2001;5572-5579.
34. Pierce A.J., Stark J.M., Araujo F.D., Moynahan M.E., Berwick M., Jasin M. Double-strand breaks and tumorigenesis. Trends Cell Biol. 11:2001;S52-59.
35. Chaudhry M.A., Weinfeld M. Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA. J. Biol. Chem. 272:1997;15650-15655.
36. Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:1991;431-434.
37. Le Page F., Guy A., Cadet J., Sarasin A., Gentil A. Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells. Nucleic Acids Res. 26:1998;1276-1281.