A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1- dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis

Journal of Lipid Research

Volumn 55, Issue 4, 2014, Pages 681-697

  Hu, Yan Wei ^a   Yang, Jun Yao ^a   Ma, Xin ^a   Chen, Zhi Ping ^a   Hu, Ya Rong ^a   Zhao, Jia Yi ^a   Li, Shu Fen ^a   Qiu, Yu Rong ^a   Lu, Jing Bo ^a   Wang, Yan Chao ^a   Gao, Ji Juan ^a   Sha, Yan Hua ^a   Zheng, Lei ^a   Wang, Qian ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; ATP binding cassette transporter A1; G protein coupled receptor 119; Glucagon like peptide 1 receptor; Long intervening noncoding ribonucleic acid DYNLRB2 2

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHOLESTEROL; CYTOPLASMIC DYNEIN; DYNLRB2 2 PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIVER RECEPTOR HOMOLOG 1; LIVER X RECEPTOR ALPHA; LONG UNTRANSLATED RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ABCA1 PROTEIN, HUMAN; AUTACOID; CYTOKINE; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GPR119 PROTEIN, HUMAN; LIPID; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; FOAM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LENTIVIRINAE; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANIMAL; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CELL LINE; GENETICS; HOMEOSTASIS; IMMUNOLOGY; KNOCKOUT MOUSE; LIVER; METABOLISM; PHYSIOLOGY; TRANSCRIPTION INITIATION;

ANIMALS; ATHEROSCLEROSIS; ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE; CHOLESTEROL; CYTOKINES; FOAM CELLS; HOMEOSTASIS; HUMANS; INFLAMMATION MEDIATORS; LIPID METABOLISM; LIPIDS; LIPOPOLYSACCHARIDES; LIPOPROTEINS, LDL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GLUCAGON; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84897386484     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M044669     Document Type: Article

References (49)

1. Yin, K., D. F. Liao, and C. K. Tang. 2010. ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport. Mol. Med. 16: 438-449.
2. Burnett, J. R. 2004. Lipids, lipoproteins, atherosclerosis and cardiovascular disease. Clin. Biochem. Rev. 25: 2.
3. Ye, D., B. Lammers, Y. Zhao, I. Meurs, T. J. Van Berkel, and M. Van Eck. 2011. ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets for the treatment of atherosclerosis. Curr. Drug Targets. 12: 647-660.
4. Oram, J. F., and R. M. Lawn. 2001. ABCA1. The gatekeeper for eliminating excess tissue cholesterol. J. Lipid Res. 42: 1173-1179.
5. Overton, H. A., A. J. Babbs, S. M. Doel, M. C. Fyfe, L. S. Gardner, G. Griffin, H. C. Jackson, M. J. Procter, C. M. Rasamison, M. Tang-Christensen, et al. 2006. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3: 167-175.
6. Swaminath, G. 2008. Fatty acid binding receptors and their physiological role in type 2 diabetes. Arch. Pharm. (Weinheim). 341: 753-761.
7. Ohishi, T., and S. Yoshida. 2012. The therapeutic potential of GPR119 agonists for type 2 diabetes. Expert Opin. Investig. Drugs. 21: 321-328.
8. Leech, C. A., I. Dzhura, O. G. Chepurny, G. Kang, F. Schwede, H. G. Genieser, and G. G. Holz. 2011. Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells. Prog. Biophys. Mol. Biol. 107: 236-247.
9. Ning, Y., K. O'Neill, H. Lan, L. Pang, L. X. Shan, B. E. Hawes, and J. A. Hedrick. 2008. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br. J. Pharmacol. 155: 1056-1065.
10. Lauffer, L. M., R. Iakoubov, and P. L. Brubaker. 2009. GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes. 58: 1058-1066.
11. Semple, G., B. Fioravanti, G. Pereira, I. Calderon, J. Uy, K. Choi, Y. Xiong, A. Ren, M. Morgan, V. Dave, et al. 2008. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J. Med. Chem. 51: 5172-5175.
12. Le Goff, W., P. Zheng, G. Brubaker, and J. D. Smith. 2006. Identification of the cAMP-responsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements. Arterioscler. Thromb. Vasc. Biol. 26: 527-533.
13. Nishiuchi, Y., K. Murao, H. Imachi, T. Nishiuchi, H. Iwama, and T. Ishida. 2010. Transcriptional factor prolactin regulatory elementbinding protein-mediated gene transcription of ABCA1 via 3′,5′-cyclic adenosine-5′-monophosphate. Atherosclerosis. 212: 418-425.
14. Hu, Y. W., X. Ma, X. X. Li, X. H. Liu, J. Xiao, Z. C. Mo, J. Xiang, D. F. Liao, and C. K. Tang. 2009. Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells. Atherosclerosis. 204: e35-e43.
15. Hansen, H. S., M. M. Rosenkilde, J. J. Holst, and T. W. Schwartz. 2012. GPR119 as a fat sensor. Trends Pharmacol. Sci. 33: 374-381.
16. Rinn, J. L., and H. Y. Chang. 2012. Genome regulation by long noncoding RNAs. Annu. Rev. Biochem. 81: 145-166.
17. Batista, P. J., and H. Y. Chang. 2013. Long noncoding RNAs: cellular address codes in development and disease. Cell. 152: 1298-1307.
18. Ng, S. Y., L. Lin, B. S. Soh, and L. W. Stanton. 2013. Long noncoding RNAs in development and disease of the central nervous system. Trends Genet. 29: 461-468.
19. Birney, E., J. A. Stamatoyannopoulos, A. Dutta, R. Guigó, T. R. Gingeras, E. H. Margulies, Z. Weng, M. Snyder, E. T. Dermitzakis, R. E. Thurman, et al.; ENCODE Project Consortium. 2007. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447: 799-816.
20. Amaral, P. P., M. E. Dinger, T. R. Mercer, and J. S. Mattick. 2008. The eukaryotic genome as an RNA machine. Science. 319: 1787-1789.
21. Tripathi, V., J. D. Ellis, Z. Shen, D. Y. Song, Q. Pan, A. T. Watt, S. M. Freier, C. F. Bennett, A. Sharma, P. A. Bubulya, et al. 2010. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell. 39: 925-938.
22. Zhang, H., Z. Chen, X. Wang, Z. Huang, Z. He, and Y. Chen. 2013. Long non-coding RNA: a new player in cancer. J. Hematol. Oncol. 6: 37.
23. Qureshi, I. A., and M. F. Mehler. 2013. Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy. Neurotherapeutics. 10: 632-646.
24. Scheuermann, J. C., and L. A. Boyer. 2013. Getting to the heart of the matter: long non-coding RNAs in cardiac development and disease. EMBO J. 32: 1805-1816.
25. Han, K. H., K. O. Han, S. R. Green, and O. Quehenberger. 1999. Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia. Differential effects of plasma lipoproteins on monocyte function. J. Lipid Res. 40: 1053-1063.
26. Shibata, N., and C. K. Glass. 2009. Regulation of macrophage function in inflammation and atherosclerosis. J. Lipid Res. 50 ( Suppl ): S277-S281.
27. Lawn, R. M., D. P. Wade, M. R. Garvin, X. Wang, K. Schwartz, J. G. Porter, J. J. Seilhamer, A. M. Vaughan, and J. F. Oram. 1999. The Tangier disease gene product ABC1 controls the cellular apolipoproteinmediated lipid removal pathway. J. Clin. Invest. 104: R25-R31.
28. Osterud, B., and E. Bjorklid. 2003. Role of monocytes in atherogenesis. Physiol. Rev. 83: 1069-1112.
29. Holz, G. G. 2004. Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes. 53: 5-13.
30. Pittman, R. C., T. E. Carew, A. D. Attie, J. L. Witztum, Y. Watanabe, and D. Steinberg. 1982. Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits. J. Biol. Chem. 257: 7994-8000.
31. Hui, D. Y., E. D. Labonté, and P. N. Howles. 2008. Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G839-G843.
32. Shepherd, J., S. M. Cobbe, I. Ford, C. G. Isles, A. R. Lorimer, P. W. MacFarlane, J. H. McKillop, and C. J. Packard ; West of Scotland Coronary Prevention Study Group. 2004. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. 1995. Atheroscler. Suppl. 5: 91-97.
33. Panel, A. P. 2006. Reducing residual cardiovascular risk: the relevance of raising high-density lipoprotein cholesterol in patients on cholesterol-lowering treatment. Diab. Vasc. Dis. Res. 3: S1-S12.
34. Tall AR. An overview of reverse cholesterol transport. Eur Heart J. 1998 ; 19 Suppl A: A31-5.
35. Tabas, I. 2000. Cholesterol and phospholipid metabolism in macrophages. Biochim. Biophys. Acta. 1529: 164-174.
36. Rader, D. J., E. T. Alexander, G. L. Weibel, J. Billheimer, and G. H. Rothblat. 2009. The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J. Lipid Res. 50 ( Suppl ): S189-S194.
37. Ohashi, R., H. Mu, X. Wang, Q. Yao, and C. Chen. 2005. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 98: 845-856.
38. Hu, Y. W., L. Zheng, and Q. Wang. 2010. Regulation of cholesterol homeostasis by liver X receptors. Clin. Chim. Acta. 411: 617-625.
39. Haidar, B., M. Denis, L. Krimbou, M. Marcil, and J. Genest, Jr. 2002. cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts. J. Lipid Res. 43: 2087-2094.
40. Lin, G., and K. E. Bornfeldt. 2002. Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux. Biochem. Biophys. Res. Commun. 290: 663-669.
41. Rigotti, A., H. E. Miettinen, and M. Krieger. 2003. The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr. Rev. 24: 357-387.
42. Rubin, E. M., R. M. Krauss, E. A. Spangler, J. G. Verstuyft, and S. M. Clift. 1991. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature. 353: 265-267.
43. Navab, K. D., O. Elboudwarej, M. Gharif, J. Yu, S. Y. Hama, S. Safarpour, G. P. Hough, L. Vakili, S. T. Reddy, M. Navab, et al. 2011. Chronic inflammatory disorders and accelerated atherosclerosis: chronic kidney disease. Curr. Pharm. Des. 17: 17-20.
44. Libby, P. 2012. Inflammation in atherosclerosis. Arterioscler. Thromb.Vasc. Biol. 32: 2045-2051.
45. Mantovani, A., C. Garlanda, and M. Locati. 2009. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler. Thromb. Vasc. Biol. 29: 1419-1423.
46. Hu, Y. W., X. Ma, J. L. Huang, X. R. Mao, J. Y. Yang, J. Y. Zhao, S. F. Li, Y. R. Qiu, J. Yang, L. Zheng, et al. 2013. Dihydrocapsaicin attenuates plaque formation through a PPARγ /LXRα pathway in apoE-/-mice fed a high-fat/high-cholesterol diet. PLoS ONE. 8: e66876.
47. Oh, D. Y., and W. S. Lagakos. 2011. The role of G-protein-coupled receptors in mediating the effect of fatty acids on inflammation and insulin sensitivity. Curr. Opin. Clin. Nutr. Metab. Care. 14: 322-327.
48. Goodrich, J. A., and J. F. Kugel. 2006. Non-coding-RNA regulators of RNA polymerase II transcription. Nat. Rev. Mol. Cell Biol. 7: 612-616.
49. Schonrock, N., R. P. Harvey, and J. S. Mattick. 2012. Long noncoding RNAs in cardiac development and pathophysiology. Circ. Res. 111: 1349-1362.