Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells

Atherosclerosis

Volumn 204, Issue 2, 2009, Pages

  Hu, Yan Wei ^a   Ma, Xin ^b   Li, Xiao Xu ^a   Liu, Xie Hong ^a   Xiao, Ji ^a   Mo, Zhong Cheng ^a   Xiang, Jim ^c   Liao, Duan Fang ^b   Tang, Chao Ke ^a  

^a Life Science Research Center   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c SASKATCHEWAN CANCER AGENCY   (Canada)

Author keywords

ABCA1; Atherosclerosis; cAMP PKA; EPA; Reverse cholesterol transport

Indexed keywords

ABC TRANSPORTER A1; CHOLESTEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; ICOSAPENTAENOIC ACID; MESSENGER RNA; SERINE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; FOAM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ACYL COENZYME A; ADENYLATE CYCLASE; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; EICOSAPENTAENOIC ACID; ENZYME ACTIVATORS; FOAM CELLS; HUMANS; PHOSPHORYLATION; PROTEIN STABILITY; RNA INTERFERENCE; RNA, MESSENGER; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 67349173154     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.11.003     Document Type: Article

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