메뉴 건너뛰기




Volumn 34, Issue 12, 2015, Pages 1532-1541

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1

Author keywords

[No Author keywords available]

Indexed keywords

AEG 40730; ALKYNE; BIRC2 PROTEIN, HUMAN; BIRC2 PROTEIN, MOUSE; CRD-BP PROTEIN, MOUSE; DIPEPTIDE; IMP-1 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; N [1 CYCLOHEXYL 2 [2 [4 (4 FLUOROBENZOYL) 2 THIAZOLYL] 1 PYRROLIDINYL] 2 OXOETHYL] 2 (METHYLAMINO)PROPANAMIDE; RNA BINDING PROTEIN; THIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84897348350     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.90     Document Type: Article
Times cited : (46)

References (50)
  • 1
    • 78649908527 scopus 로고    scopus 로고
    • Childhood rhabdomyosarcoma: New insight on biology and treatment
    • Huh WW, Skapek SX. Childhood rhabdomyosarcoma: new insight on biology and treatment. Curr Oncol Rep 2010; 12: 402-410.
    • (2010) Curr Oncol Rep , vol.12 , pp. 402-410
    • Huh, W.W.1    Skapek, S.X.2
  • 2
    • 79551488442 scopus 로고    scopus 로고
    • Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle
    • Saab R, Spunt SL, Skapek SX. Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle. Curr Top Dev Biol 2011; 94: 197-234.
    • (2011) Curr Top Dev Biol , vol.94 , pp. 197-234
    • Saab, R.1    Spunt, S.L.2    Skapek, S.X.3
  • 3
    • 84856372062 scopus 로고    scopus 로고
    • Cell death pathways as therapeutic targets in rhabdomyosarcoma
    • Fulda S. Cell death pathways as therapeutic targets in rhabdomyosarcoma. Sarcoma 2012; 2012: 326210.
    • (2012) Sarcoma , vol.2012 , pp. 326210
    • Fulda, S.1
  • 4
    • 2442464889 scopus 로고    scopus 로고
    • Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks
    • Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004; 23: 2934-2949.
    • (2004) Oncogene , vol.23 , pp. 2934-2949
    • Pommier, Y.1    Sordet, O.2    Antony, S.3    Hayward, R.L.4    Kohn, K.W.5
  • 5
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen M, Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010; 10: 561-574.
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 6
    • 2342430610 scopus 로고    scopus 로고
    • Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element
    • Warnakulasuriyarachchi D, Cerquozzi S, Cheung HH, Holcik M. Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element. J Biol Chem 2004; 279: 17148-17157.
    • (2004) J Biol Chem , vol.279 , pp. 17148-17157
    • Warnakulasuriyarachchi, D.1    Cerquozzi, S.2    Cheung, H.H.3    Holcik, M.4
  • 7
    • 1242273881 scopus 로고    scopus 로고
    • Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress
    • Van Eden ME, Byrd MP, Sherrill KW, Lloyd RE. Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress. RNA, 2004; 10: 469-481.
    • (2004) RNA , vol.10 , pp. 469-481
    • Van Eden, M.E.1    Byrd, M.P.2    Sherrill, K.W.3    Lloyd, R.E.4
  • 8
    • 77949540575 scopus 로고    scopus 로고
    • NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response
    • Graber TE, Baird SD, Kao PN, Mathews MB, Holcik M. NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response. Cell Death Differ 2010; 17: 719-729.
    • (2010) Cell Death Differ , vol.17 , pp. 719-729
    • Graber, T.E.1    Baird, S.D.2    Kao, P.N.3    Mathews, M.B.4    Holcik, M.5
  • 9
    • 17144424622 scopus 로고    scopus 로고
    • Translational control in stress and apoptosis
    • Holcik M, Sonenberg N. Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 2005; 6: 318-327.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 318-327
    • Holcik, M.1    Sonenberg, N.2
  • 10
    • 34547907409 scopus 로고    scopus 로고
    • A search for structurally similar cellular internal ribosome entry sites
    • Baird SD, Lewis SM, Turcotte M, Holcik M. A search for structurally similar cellular internal ribosome entry sites. Nucleic Acids Res 2007; 35: 4664-4677.
    • (2007) Nucleic Acids Res , vol.35 , pp. 4664-4677
    • Baird, S.D.1    Lewis, S.M.2    Turcotte, M.3    Holcik, M.4
  • 11
    • 0034764497 scopus 로고    scopus 로고
    • Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites
    • Vagner S, Galy B, Pyronnet S. Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites. EMBO Rep 2001; 2: 893-898.
    • (2001) EMBO Rep , vol.2 , pp. 893-898
    • Vagner, S.1    Galy, B.2    Pyronnet, S.3
  • 12
    • 78649758055 scopus 로고    scopus 로고
    • The role of IRES trans-acting factors in regulating translation initiation
    • King HA, Cobbold LC, Willis AE. The role of IRES trans-acting factors in regulating translation initiation. Biochem Soc Trans 2010; 38: 1581-1586.
    • (2010) Biochem Soc Trans , vol.38 , pp. 1581-1586
    • King, H.A.1    Cobbold, L.C.2    Willis, A.E.3
  • 13
    • 13544262618 scopus 로고    scopus 로고
    • VICKZ proteins: A multi-talented family of regulatory RNA-binding proteins
    • Yisraeli JK. VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. Biol Cell 2005; 97: 87-96.
    • (2005) Biol Cell , vol.97 , pp. 87-96
    • Yisraeli, J.K.1
  • 15
    • 0037421207 scopus 로고    scopus 로고
    • Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment
    • Farina KL, Huttelmaier S, Musunuru K, Darnell R, Singer RH. Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment. J Cell Biol 2003; 160: 77-87.
    • (2003) J Cell Biol , vol.160 , pp. 77-87
    • Farina, K.L.1    Huttelmaier, S.2    Musunuru, K.3    Darnell, R.4    Singer, R.H.5
  • 17
    • 58149092016 scopus 로고    scopus 로고
    • Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs
    • Weidensdorfer D, Stohr N, Baude A, Lederer M, Kohn M, Schierhorn A et al. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA 2009; 15: 104-115.
    • (2009) RNA , vol.15 , pp. 104-115
    • Weidensdorfer, D.1    Stohr, N.2    Baude, A.3    Lederer, M.4    Kohn, M.5    Schierhorn, A.6
  • 18
    • 28544443162 scopus 로고    scopus 로고
    • Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1
    • Huttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X et al. Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature 2005; 438: 512-515.
    • (2005) Nature , vol.438 , pp. 512-515
    • Huttelmaier, S.1    Zenklusen, D.2    Lederer, M.3    Dictenberg, J.4    Lorenz, M.5    Meng, X.6
  • 19
    • 84873488006 scopus 로고    scopus 로고
    • MTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
    • Dai N, Christiansen J, Nielsen FC, Avruch J. mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev 2013; 27: 301-312.
    • (2013) Genes Dev , vol.27 , pp. 301-312
    • Dai, N.1    Christiansen, J.2    Nielsen, F.C.3    Avruch, J.4
  • 21
    • 2942534884 scopus 로고    scopus 로고
    • Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice
    • Hansen TV, Hammer NA, Nielsen J, Madsen M, Dalbaeck C, Wewer UM et al. Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol 2004; 24: 4448-4464.
    • (2004) Mol Cell Biol , vol.24 , pp. 4448-4464
    • Hansen, T.V.1    Hammer, N.A.2    Nielsen, J.3    Madsen, M.4    Dalbaeck, C.5    Wewer, U.M.6
  • 22
    • 84880313066 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): Post-transcriptional drivers of cancer progression?
    • Bell JL, Wachter K, Muhleck B, Pazaitis N, Kohn M, Lederer M et al. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci 2013; 70: 2657-2675.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 2657-2675
    • Bell, J.L.1    Wachter, K.2    Muhleck, B.3    Pazaitis, N.4    Kohn, M.5    Lederer, M.6
  • 23
    • 1642453826 scopus 로고    scopus 로고
    • Mammary tumor induction in transgenic mice expressing an RNA-binding protein
    • Tessier CR, Doyle GA, Clark BA, Pitot HC, Ross J. Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 2004; 64: 209-214.
    • (2004) Cancer Res , vol.64 , pp. 209-214
    • Tessier, C.R.1    Doyle, G.A.2    Clark, B.A.3    Pitot, H.C.4    Ross, J.5
  • 24
    • 79952769292 scopus 로고    scopus 로고
    • IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2
    • Mongroo PS, Noubissi FK, Cuatrecasas M, Kalabis J, King CE, Johnstone CN et al. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res 2011; 71: 2172-2182.
    • (2011) Cancer Res , vol.71 , pp. 2172-2182
    • Mongroo, P.S.1    Noubissi, F.K.2    Cuatrecasas, M.3    Kalabis, J.4    King, C.E.5    Johnstone, C.N.6
  • 26
    • 84856255165 scopus 로고    scopus 로고
    • IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling
    • Stohr N, Kohn M, Lederer M, Glass M, Reinke C, Singer RH et al. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev 2012; 26: 176-189.
    • (2012) Genes Dev , vol.26 , pp. 176-189
    • Stohr, N.1    Kohn, M.2    Lederer, M.3    Glass, M.4    Reinke, C.5    Singer, R.H.6
  • 28
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
    • Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 2010; 141: 129-141.
    • (2010) Cell , vol.141 , pp. 129-141
    • Hafner, M.1    Landthaler, M.2    Burger, L.3    Khorshid, M.4    Hausser, J.5    Berninger, P.6
  • 30
    • 0033760404 scopus 로고    scopus 로고
    • Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis
    • Petak I, Douglas L, Tillman DM, Vernes R, Houghton JA. Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis. Clin Cancer Res 2000; 6: 4119-4127.
    • (2000) Clin Cancer Res , vol.6 , pp. 4119-4127
    • Petak, I.1    Douglas, L.2    Tillman, D.M.3    Vernes, R.4    Houghton, J.A.5
  • 31
    • 7444240359 scopus 로고    scopus 로고
    • Casein kinase i attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex
    • Izeradjene K, Douglas L, Delaney AB, Houghton JA. Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res 2004; 64: 8036-8044.
    • (2004) Cancer Res , vol.64 , pp. 8036-8044
    • Izeradjene, K.1    Douglas, L.2    Delaney, A.B.3    Houghton, J.A.4
  • 32
    • 5144220294 scopus 로고    scopus 로고
    • Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells
    • Izeradjene K, Douglas L, Delaney A, Houghton JA. Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. Clin Cancer Res 2004; 10: 6650-6660.
    • (2004) Clin Cancer Res , vol.10 , pp. 6650-6660
    • Izeradjene, K.1    Douglas, L.2    Delaney, A.3    Houghton, J.A.4
  • 33
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 34
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-681.
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1    Blankenship, J.W.2    Wayson, S.M.3    Fedorova, A.V.4    Kayagaki, N.5    Garg, P.6
  • 35
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimeticinduced apoptosis
    • Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimeticinduced apoptosis. Cancer Cell 2007; 12: 445-456.
    • (2007) Cancer Cell , vol.12 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6
  • 36
    • 44949240664 scopus 로고    scopus 로고
    • CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700.
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 37
    • 84869056283 scopus 로고    scopus 로고
    • RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis
    • Basit F, Humphreys R, Fulda S. RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis. J Biol Chem 2012; 287: 38767-38777.
    • (2012) J Biol Chem , vol.287 , pp. 38767-38777
    • Basit, F.1    Humphreys, R.2    Fulda, S.3
  • 39
    • 0037144569 scopus 로고    scopus 로고
    • Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis
    • Weingartner M, Siegmund D, Schlecht U, Fotin-Mleczek M, Scheurich P, Wajant H. Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis. J Biol Chem 2002; 277: 34853-34859.
    • (2002) J Biol Chem , vol.277 , pp. 34853-34859
    • Weingartner, M.1    Siegmund, D.2    Schlecht, U.3    Fotin-Mleczek, M.4    Scheurich, P.5    Wajant, H.6
  • 40
    • 0037012555 scopus 로고    scopus 로고
    • The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis
    • Yaniv K, Yisraeli JK. The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis. Gene 2002; 287: 49-54.
    • (2002) Gene , vol.287 , pp. 49-54
    • Yaniv, K.1    Yisraeli, J.K.2
  • 41
    • 84871893152 scopus 로고    scopus 로고
    • Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon
    • Faye MD, Graber TE, Liu P, Thakor N, Baird SD, Durie D et al. Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon. Mol Cell Biol 2013; 33: 307-318.
    • (2013) Mol Cell Biol , vol.33 , pp. 307-318
    • Faye, M.D.1    Graber, T.E.2    Liu, P.3    Thakor, N.4    Baird, S.D.5    Durie, D.6
  • 42
    • 38349167513 scopus 로고    scopus 로고
    • The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress
    • Lewis SM, Cerquozzi S, Graber TE, Ungureanu NH, Andrews M, Holcik M. The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress. Nucleic Acids Res 2008; 36: 168-178.
    • (2008) Nucleic Acids Res , vol.36 , pp. 168-178
    • Lewis, S.M.1    Cerquozzi, S.2    Graber, T.E.3    Ungureanu, N.H.4    Andrews, M.5    Holcik, M.6
  • 43
    • 79958064675 scopus 로고    scopus 로고
    • MTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
    • Dai N, Rapley J, Angel M, Yanik MF. Blower MD, Avruch J. mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev 2011; 25: 1159-1172.
    • (2011) Genes Dev , vol.25 , pp. 1159-1172
    • Dai, N.1    Rapley, J.2    Angel, M.3    Yanik, M.F.4    Blower, M.D.5    Avruch, J.6
  • 44
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule Smac mimic potentiates TRAIL-and TNFalpha-mediated cell death
    • Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. A small molecule Smac mimic potentiates TRAIL-and TNFalpha-mediated cell death. Science 2004; 305: 1471-1474.
    • (2004) Science , vol.305 , pp. 1471-1474
    • Li, L.1    Thomas, R.M.2    Suzuki, H.3    De Brabander, J.K.4    Wang, X.5    Harran, P.G.6
  • 45
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • LaCasse EC, Baird S, Korneluk RG, MacKenzie AE. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 1998; 17: 3247-3259.
    • (1998) Oncogene , vol.17 , pp. 3247-3259
    • Lacasse, E.C.1    Baird, S.2    Korneluk, R.G.3    MacKenzie, A.E.4
  • 46
    • 0036629347 scopus 로고    scopus 로고
    • Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
    • Fotin-Mleczek M, Henkler F, Samel D, Reichwein M, Hausser A, Parmryd I et al. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci 2002; 115: 2757-2770.
    • (2002) J Cell Sci , vol.115 , pp. 2757-2770
    • Fotin-Mleczek, M.1    Henkler, F.2    Samel, D.3    Reichwein, M.4    Hausser, A.5    Parmryd, I.6
  • 49
    • 9144264424 scopus 로고    scopus 로고
    • Cloning and characterization of the rat homologues of the inhibitor of apoptosis protein 1, 2, and 3 genes
    • Holcik M, Lefebvre CA, Hicks K, Korneluk RG. Cloning and characterization of the rat homologues of the inhibitor of apoptosis protein 1, 2, and 3 genes. BMC Genom 2002; 3: 5.
    • (2002) BMC Genom , vol.3 , pp. 5
    • Holcik, M.1    Lefebvre, C.A.2    Hicks, K.3    Korneluk, R.G.4
  • 50
    • 78650305755 scopus 로고    scopus 로고
    • Smac mimetics: Implications for enhancement of targeted therapies in leukemia
    • Weisberg E, Ray A, Barrett R, Nelson E, Christie AL, Porter D et al. Smac mimetics: implications for enhancement of targeted therapies in leukemia. Leukemia 2010; 24: 2100-2109.
    • (2010) Leukemia , vol.24 , pp. 2100-2109
    • Weisberg, E.1    Ray, A.2    Barrett, R.3    Nelson, E.4    Christie, A.L.5    Porter, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.