-
1
-
-
80051748943
-
Insulin resistance: The link between obesity and cardiovascular disease
-
Reaven, G. M. Insulin resistance: the link between obesity and cardiovascular disease. Med. Clin. North Am. 95, 875-892 (2011).
-
(2011)
Med. Clin. North Am.
, vol.95
, pp. 875-892
-
-
Reaven, G.M.1
-
2
-
-
79551538263
-
Update on the prevention of type 2 diabetes
-
Karam, J. G. & McFarlane, S. I. Update on the prevention of type 2 diabetes. Curr. Diab. Rep. 11, 56-63 (2011).
-
(2011)
Curr. Diab. Rep.
, vol.11
, pp. 56-63
-
-
Karam, J.G.1
McFarlane, S.I.2
-
3
-
-
0037026739
-
Insulin resistance as the core defect in type 2 diabetes mellitus
-
Goldstein, B. J. Insulin resistance as the core defect in type 2 diabetes mellitus. Am. J. Cardiol. 90, 3G-10G (2002).
-
(2002)
Am. J. Cardiol.
, vol.90
, pp. 3G-10G
-
-
Goldstein, B.J.1
-
4
-
-
0029095414
-
Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia
-
Pieper, G. M., Meier, D. A. & Hager, S. R. Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia. Am. J. Physiol. 269, H845-H850 (1995).
-
(1995)
Am. J. Physiol.
, vol.269
, pp. H845-H850
-
-
Pieper, G.M.1
Meier, D.A.2
Hager, S.R.3
-
5
-
-
0035180299
-
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
-
Du, X. L. et al. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J. Clin. Invest. 108, 1341-1348 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1341-1348
-
-
Du, X.L.1
-
6
-
-
0037022206
-
Insulin causes endothelial dysfunction in humans: Sites and mechanisms
-
Arcaro, G. et al. Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 105, 576-582 (2002).
-
(2002)
Circulation
, vol.105
, pp. 576-582
-
-
Arcaro, G.1
-
7
-
-
80053570632
-
Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-kappaB pathway in rat aorta
-
Li, H., Li, H., Bao, Y., Zhang, X. & Yu, Y. Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-kappaB pathway in rat aorta. Int. J. Cardiol. 152, 218-224 (2011).
-
(2011)
Int. J. Cardiol.
, vol.152
, pp. 218-224
-
-
Li, H.1
Li, H.2
Bao, Y.3
Zhang, X.4
Yu, Y.5
-
8
-
-
29144477288
-
Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: Role of Akt-stimulated NO production
-
Ma, H. et al. Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production. Cardiovasc. Res. 69, 57-65 (2006).
-
(2006)
Cardiovasc. Res.
, vol.69
, pp. 57-65
-
-
Ma, H.1
-
9
-
-
77955292064
-
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein e null mice
-
Rask-Madsen, C. et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 11, 379-389 (2010).
-
(2010)
Cell Metab.
, vol.11
, pp. 379-389
-
-
Rask-Madsen, C.1
-
10
-
-
79952142784
-
Impaired insulin signaling in endothelial cells reduces insulininduced glucose uptake by skeletal muscle
-
Kubota, T. et al. Impaired insulin signaling in endothelial cells reduces insulininduced glucose uptake by skeletal muscle. Cell Metab. 13, 294-307 (2011).
-
(2011)
Cell Metab.
, vol.13
, pp. 294-307
-
-
Kubota, T.1
-
11
-
-
0019762341
-
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
-
DeFronzo, R. A. et al. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000-1007 (1981).
-
(1981)
Diabetes
, vol.30
, pp. 1000-1007
-
-
DeFronzo, R.A.1
-
12
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng, C. N. & Saltiel, A. R. Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
13
-
-
34848851922
-
Angiogenesis modulates adipogenesis and obesity
-
Cao, Y. Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 117, 2362-2368 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2362-2368
-
-
Cao, Y.1
-
14
-
-
0020608986
-
The thermogenic mechanism of brown adipose tissue
-
Nicholls, D. G. The thermogenic mechanism of brown adipose tissue. Review. Biosci. Rep. 3, 431-441 (1983).
-
(1983)
Review. Biosci. Rep.
, vol.3
, pp. 431-441
-
-
Nicholls, D.G.1
-
15
-
-
75849165542
-
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
-
Cao, Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat. Rev. Drug Discov. 9, 107-115 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 107-115
-
-
Cao, Y.1
-
16
-
-
57849153917
-
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
-
Xue, Y. et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99-109 (2009).
-
(2009)
Cell Metab.
, vol.9
, pp. 99-109
-
-
Xue, Y.1
-
17
-
-
77958508121
-
Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice
-
Zhang, X. et al. Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. J. Biol. Chem. 285, 32869-32877 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32869-32877
-
-
Zhang, X.1
-
18
-
-
61349087443
-
Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling
-
Ma, F. et al. Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling. Genes Cells 14, 281-293 (2009).
-
(2009)
Genes Cells
, vol.14
, pp. 281-293
-
-
Ma, F.1
-
19
-
-
66249131316
-
Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2
-
Ikeda, K. et al. Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Proc. Natl Acad. Sci. USA 106, 8227-8232 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 8227-8232
-
-
Ikeda, K.1
-
20
-
-
51649117146
-
ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis
-
Armstrong, L. J. et al. ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. Arterioscler. Thromb. Vasc. Biol. 28, 1640-1646 (2008).
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 1640-1646
-
-
Armstrong, L.J.1
-
21
-
-
43049128529
-
Tenets of PTEN tumor suppression
-
Salmena, L., Carracedo, A. & Pandolfi, P. P. Tenets of PTEN tumor suppression. Cell 133, 403-414 (2008).
-
(2008)
Cell
, vol.133
, pp. 403-414
-
-
Salmena, L.1
Carracedo, A.2
Pandolfi, P.P.3
-
22
-
-
67449152446
-
Phosphoinositide 3-kinase signalling in the vascular system
-
Morello, F., Perino, A. & Hirsch, E. Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc. Res. 82, 261-271 (2009).
-
(2009)
Cardiovasc. Res.
, vol.82
, pp. 261-271
-
-
Morello, F.1
Perino, A.2
Hirsch, E.3
-
23
-
-
77953188523
-
Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
-
Xia, H. et al. Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am. J. Pathol. 176, 2626-2637 (2010).
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2626-2637
-
-
Xia, H.1
-
24
-
-
79959346367
-
Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells
-
Koide, M. et al. Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells. Proc. Natl Acad. Sci. USA 108, 9472-9477 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9472-9477
-
-
Koide, M.1
-
25
-
-
0033669849
-
In silico cloning of novel endothelial-specific genes
-
Huminiecki, L. & Bicknell, R. In silico cloning of novel endothelial-specific genes. Genome Res. 10, 1796-1806 (2000).
-
(2000)
Genome Res.
, vol.10
, pp. 1796-1806
-
-
Huminiecki, L.1
Bicknell, R.2
-
26
-
-
0025954408
-
Mechanism of insulin resistance in insulin-dependent diabetes mellitus: A major role for reduced skeletal muscle blood flow
-
Baron, A. D., Laakso, M., Brechtel, G. & Edelman, S. V. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J. Clin. Endocrinol. Metab. 73, 637-643 (1991).
-
(1991)
J. Clin. Endocrinol. Metab.
, vol.73
, pp. 637-643
-
-
Baron, A.D.1
Laakso, M.2
Brechtel, G.3
Edelman, S.V.4
-
27
-
-
0026801899
-
Impaired insulinmediated skeletal muscle blood flow in patients with NIDDM
-
Laakso, M., Edelman, S. V., Brechtel, G. & Baron, A. D. Impaired insulinmediated skeletal muscle blood flow in patients with NIDDM. Diabetes 41, 1076-1083 (1992).
-
(1992)
Diabetes
, vol.41
, pp. 1076-1083
-
-
Laakso, M.1
Edelman, S.V.2
Brechtel, G.3
Baron, A.D.4
-
28
-
-
0028316832
-
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake
-
Baron, A. D., Steinberg, H., Brechtel, G. & Johnson, A. Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am. J. Physiol. 266, E248-E253 (1994).
-
(1994)
Am. J. Physiol.
, vol.266
, pp. E248-E253
-
-
Baron, A.D.1
Steinberg, H.2
Brechtel, G.3
Johnson, A.4
-
29
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
-
Klaman, L. D. et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell Biol. 20, 5479-5489 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
-
30
-
-
78649961357
-
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
-
Chakraborty, A. et al. Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell 143, 897-910 (2010).
-
(2010)
Cell
, vol.143
, pp. 897-910
-
-
Chakraborty, A.1
-
31
-
-
0031870959
-
Pten is essential for embryonic development and tumour suppression
-
Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19, 348-355 (1998).
-
(1998)
Nat. Genet.
, vol.19
, pp. 348-355
-
-
Di Cristofano, A.1
Pesce, B.2
Cordon-Cardo, C.3
Pandolfi, P.P.4
-
32
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A. & Nussbaum, R. L. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J. Biol. Chem. 274, 10963-10968 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
33
-
-
0036185944
-
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
-
Bi, L., Okabe, I., Bernard, D. J. & Nussbaum, R. L. Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm. Genome 13, 169-172 (2002).
-
(2002)
Mamm. Genome
, vol.13
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
34
-
-
77951765345
-
Subtle variations in Pten dose determine cancer susceptibility
-
Alimonti, A. et al. Subtle variations in Pten dose determine cancer susceptibility. Nat. Genet. 42, 454-458 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 454-458
-
-
Alimonti, A.1
-
35
-
-
0345900899
-
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis
-
Fukumura, D. et al. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ. Res. 93, e88-e97 (2003).
-
(2003)
Circ. Res.
, vol.93
, pp. e88-e97
-
-
Fukumura, D.1
-
36
-
-
0035203313
-
Human adipose tissue endothelial cells promote preadipocyte proliferation
-
Hutley, L. J. et al. Human adipose tissue endothelial cells promote preadipocyte proliferation. Am. J. Physiol. Endocrinol. Metab. 281, E1037-E1044 (2001).
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.281
, pp. E1037-E1044
-
-
Hutley, L.J.1
-
37
-
-
0038714289
-
Endothelial signaling during development
-
Cleaver, O. & Melton, D. A. Endothelial signaling during development. Nat. Med. 9, 661-668 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 661-668
-
-
Cleaver, O.1
Melton, D.A.2
-
38
-
-
79960768692
-
Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
-
Barrett, E. J., Wang, H., Upchurch, C. T. & Liu, Z. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am. J. Physiol. Endocrinol. Metab. 301, E252-E263 (2011).
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.301
, pp. E252-E263
-
-
Barrett, E.J.1
Wang, H.2
Upchurch, C.T.3
Liu, Z.4
-
39
-
-
77954838441
-
The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action
-
Richards, O. C., Raines, S. M. & Attie, A. D. The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action. Endocr. Rev. 31, 343-363 (2010).
-
(2010)
Endocr. Rev.
, vol.31
, pp. 343-363
-
-
Richards, O.C.1
Raines, S.M.2
Attie, A.D.3
-
40
-
-
84856529575
-
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
-
Ouellet, V. et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J. Clin. Invest. 122, 545-552 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 545-552
-
-
Ouellet, V.1
-
41
-
-
0032584609
-
Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes
-
Tamori, Y. et al. Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes. J. Biol. Chem. 273, 19740-19746 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 19740-19746
-
-
Tamori, Y.1
-
42
-
-
70450230450
-
Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system
-
Uraoka, M. et al. Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system. Biochem. Biophys. Res. Commun. 390, 1202-1207 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.390
, pp. 1202-1207
-
-
Uraoka, M.1
-
43
-
-
84555195142
-
Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation
-
Kimura, K. et al. Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Diabetes 61, 61-73 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 61-73
-
-
Kimura, K.1
-
44
-
-
75749127447
-
Increased expression of DNA methyltransferase 3a in obese adipose tissue: Studies with transgenic mice
-
Kamei, Y. et al. Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice. Obesity (Silver Spring) 18, 314-321 (2010).
-
(2010)
Obesity (Silver Spring)
, vol.18
, pp. 314-321
-
-
Kamei, Y.1
-
45
-
-
20244380182
-
Angiopoietin-related growth factor antagonizes obesity and insulin resistance
-
Oike, Y. et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med. 11, 400-408 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 400-408
-
-
Oike, Y.1
-
46
-
-
69149090011
-
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance
-
Tabata, M. et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 10, 178-188 (2009).
-
(2009)
Cell Metab.
, vol.10
, pp. 178-188
-
-
Tabata, M.1
-
47
-
-
77955480472
-
Adipose angiogenesis: Quantitative methods to study microvessel growth, regression and remodeling in vivo
-
Xue, Y., Lim, S., Brakenhielm, E. & Cao, Y. Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo. Nat. Protoc. 5, 912-920 (2010).
-
(2010)
Nat. Protoc.
, vol.5
, pp. 912-920
-
-
Xue, Y.1
Lim, S.2
Brakenhielm, E.3
Cao, Y.4
-
48
-
-
23844480941
-
Plasmid delivery in vivo from porous tissue-engineering scaffolds: Transgene expression and cellular transfection
-
Jang, J. H., Rives, C. B. & Shea, L. D. Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection. Mol. Ther. 12, 475-483 (2005).
-
(2005)
Mol. Ther.
, vol.12
, pp. 475-483
-
-
Jang, J.H.1
Rives, C.B.2
Shea, L.D.3
-
49
-
-
12244275679
-
A computer image analysis system for microvessel density measurement in solid tumours
-
Goddard, J. C., Sutton, C. D., Furness, P. N., Kockelbergh, R. C. & O'Byrne, K. J. A computer image analysis system for microvessel density measurement in solid tumours. Angiogenesis 5, 15-20 (2002).
-
(2002)
Angiogenesis
, vol.5
, pp. 15-20
-
-
Goddard, J.C.1
Sutton, C.D.2
Furness, P.N.3
Kockelbergh, R.C.4
O'Byrne, K.J.5
-
50
-
-
33747390456
-
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization
-
Ikeda, K. et al. Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Circ. Res. 99, 424-433 (2006).
-
(2006)
Circ. Res.
, vol.99
, pp. 424-433
-
-
Ikeda, K.1
-
51
-
-
0030858058
-
Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart
-
Lopaschuk, G. D. & Barr, R. L. Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart. Mol. Cell. Biochem. 172, 137-147 (1997).
-
(1997)
Mol. Cell. Biochem.
, vol.172
, pp. 137-147
-
-
Lopaschuk, G.D.1
Barr, R.L.2
-
52
-
-
0030831493
-
Direct measurement of energy metabolism in the isolated working rat heart
-
Barr, R. L. & Lopaschuk, G. D. Direct measurement of energy metabolism in the isolated working rat heart. J. Pharmacol. Toxicol. Methods 38, 11-17 (1997).
-
(1997)
J. Pharmacol. Toxicol. Methods
, vol.38
, pp. 11-17
-
-
Barr, R.L.1
Lopaschuk, G.D.2
|