Direct measurement of energy metabolism in the isolated working rat heart

Journal of Pharmacological and Toxicological Methods

Volumn 38, Issue 1, 1997, Pages 11-17

  Barr, Rick L ^a   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

ATP production rates; Energy metabolism; Fatty acid oxidation; Lactate oxidation

Indexed keywords

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; FATTY ACID OXIDATION; GLUCOSE OXIDATION; GLYCOLYSIS; HEART; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; RAT; SCINTILLATION; WORKLOAD;

EID: 0030831493     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(97)86574-4     Document Type: Article

References (7)

1. Neely JR, Morgan HE (1974) Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol 36:413-459.
2. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO (1994) Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1213:263-276.
3. Lopaschuk GD, Wambolt RB, Barr RL (1993) An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Ther 263:135-144.
4. Kudo N, Barr AJ, Barr RL, Desai S, Lopaschuk GD High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270:17513-17520.
5. Saddik M, Lopaschuk GD (1991) Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem 266:8162-8170.
6. Liu B, Clanachan AS, Schulz R, Lopaschuk GD (1996) Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 79:940-948.
7. Lopaschuk GD, Barr RL Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart. Mol Cell Biochem (in press).