Design and synthesis of cationic antibacterial peptide based on Leucrocin i sequence, antibacterial peptide from crocodile (Crocodylus siamensis) white blood cell extracts

Journal of Antibiotics

Volumn 67, Issue 3, 2014, Pages 205-212

  Yaraksa, Nualyai ^a   Anunthawan, Thitiporn ^a   Theansungnoen, Tinnakorn ^a   Daduang, Sakda ^a   Araki, Tomohiro ^b   Dhiravisit, Apisak ^c   Thammasirirak, Sompong ^a  

^a Khon Kaen University   (Thailand)

^b TOKAI UNIVERSITY   (Japan)

^c KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Antibacterial peptide; Cationic antibacterial peptide; Killing mechanism; Scanning electron microscopy; Transmission electron microscopy

Indexed keywords

DEXTRO NY15 PEPTIDE; LEUCROCIN I; LEUKOCYTE EXTRACT; LEVO NY15 PEPTIDE; NY15 PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS MEGATERIUM; BACTERIAL MEMBRANE; BACTERIAL OUTER MEMBRANE; BACTERICIDAL ACTIVITY; BACTERIOLYSIS; BACTERIUM ISOLATE; CONTROLLED STUDY; CROCODILE; CROCODYLUS SIAMENSIS; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; ENANTIOMER; ERYTHROCYTE; ESCHERICHIA COLI O157; FLUORESCENCE; HUMAN; HUMAN CELL; LYSINIBACILLUS SPHAERICUS; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHI; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VIBRIO CHOLERAE;

ALLIGATORS AND CROCODILES; AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL EXTRACTS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; DRUG DESIGN; HUMANS; LEUKOCYTES; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; STEREOISOMERISM; TOXICITY TESTS; VERO CELLS; VIBRIO CHOLERAE;

EID: 84897127735     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.114     Document Type: Article

References (41)

1. Reddy, K. V. R., Yedery, R. D. & Aranha, C. Antimicrobial peptides: Premises and promises. Int. J. Antimicrob. Agents 24, 536-547 (2004
2. Hancock, R. E. & Patrzykat, A. Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics. Curr. Drug Targets Infect. Dis. 2, 79-83 (2002
3. Jenssen, H., Hamill, P. & Hancock, R. E. Peptide antimicrobial agents. Clin. Microbiol. Rev. 19, 491-511 (2006
4. Scott, M. G. & Hancock, R. E. Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit. Rev. Immunol. 20, 407-431 (2000
5. Hancock, R. E. Cationic peptides: Effectors in innate immunity and novel antimicrobials. Lancet. Infect. Dis. 1, 156-164 (2001
6. Yeaman, M. R. & Yount, N. Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 55, 27-55 (2003
7. Dathe, M. & Wieprecht, T. Structural features of helical antimicrobial peptides: Their potential to modulate activity on model membranes and biological cells. Biochim. Biophys. Acta Biomembr. 1462, 71-87 (1999
8. Brogden, K. A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria. Nat. Rev. Microbiol. 3, 238-250 (2005
9. Tossi, A., Sandri, L. & Giangaspero, A. Amphipathic, alpha-helical antimicrobial peptides. Biopolymers 55, 4-30 (2000
10. Pata, S. et al. Characterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts. Dev. Comp. Immunol. 35, 545-553 (2011
11. Tossi, A., Tarantino, C. & Romeo, D. Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity. Eur. J. Biochem. 250, 549-558 (1997
12. Blondelle, S. E. Synthetic combinatorial libraries: Novel discovery strategy for identification of antimicrobial agents. Antimicrob. Agents Chemother 40, 1067-1071 (1996
13. Blondelle, S. E., Takahashi, E., Dinh, K. T. & Houghten, R. A. The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries. J. Appl. Microbiol. 78, 39-46 (1995
14. Hong, S. Y. et al. Identification and characterization of novel antimicrobial decapeptides generated by combinatorial chemistry. Antimicrob. Agents Chemother 42, 2534-2541 (1998
15. Blondelle, S. E. & Lohner, K. Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-Activity relationship studies. Biopolymers 55, 74-87 (2000
16. Zelezetsky, I. & Tossi, A. Alpha-helical antimicrobial peptides-using a sequence template to guide structure-Activity relationship studies. Biochim. Biophy. Acta - Biomembr. 1758, 1436-1449 2006
17. Chan, D. I., Prenner, E. J. & Vogel, H. J. Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action. Biochim. Biophy. Acta Biomembr. 1758, 1184-1202 2006
18. Wang, Z. & Wang, G. APD: The antimicrobial peptide database. Nucleic Acids Res. 32, 590-592 (2004
19. Yang, S-T. et al. Selective cytotoxicity following Arg-To-Lys substitution in tritrpticin adopting a unique amphipathic turn structure. FEBS Lett. 540, 229-233 (2003
20. Ahn, H-s. et al. Design and synthesis of novel antimicrobial peptides on the basis of alpha helical domain of Tenecin 1, an insect defensin protein, and structure-Activity relationship study. Peptides 27, 640-648 (2006
21. Chou, H-T. et al. Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp. Int. J. Antimicrob. Agents 32, 130-138 (2008
22. Duval, E., Zatylny, C., Laurencin, M., Baudy-Floc'h, M. & Henry, J. KKKKPLFGLFFGLF: A cationic peptide designed to exert antibacterial activity. Peptides 30, 1608-1612 (2009
23. Yang, S-T., Shin, S. Y., Hahm, K-S. & Kim, J. I. Design of perfectly symmetric Trp-rich peptides with potent and broad-spectrum antimicrobial activities. Int. J. Antimicrob. Agents 27, 325-330 (2006
24. Boman, H. G., Agerberth, B. & Boman, A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect. Immun. 61, 2978-2984 (1993
25. Li, L., Shi, Y., Su, G. & Le, G. Selectivity for and destruction of Salmonella typhimurium via a membrane damage mechanism of a cell-penetrating peptide ppTG20 analogue. Int. J. Antimicrob. Agents 40, 337-343 (2012
26. Park, C. B., Kim, H. S. & Kim, S. C. Mechanism of action of the antimicrobial peptide Buforin II: Buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys. Res. Commun. 244, 253-257 (1998
27. Lau, S. K. P. et al. Eggerthella hongkongensis sp. nov. and eggerthella sinensis sp. nov., two novel Eggerthella species, account for half of the cases of Eggerthella bacteremia. Diagn. Microbiol. Infect. Dis 49, 255-263 (2004
28. Hao, G., Shi, Y-H., Tang, Y-L. & Le, G-W. The membrane action mechanism of analogs of the antimicrobial peptide Buforin 2. Peptides 30, 1421-1427 (2009
29. Lung, F-D. T. et al. Discovery of potent antimicrobial peptide analogs of Ixosin-B. Bioorg. Med. Chem. Lett. 22, 4185-4188 (2012
30. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395 (2002
31. Vorland, L. H. et al. Antibacterial effects of lactoferricin B. Scand. J. Infect. Dis. 31, 179-184 (1999
32. Wade, D. et al. All-D amino acid-containing channel-forming antibiotic peptides. Proc. Natl Acad. Sci. USA 87, 4761-4765 (1999
33. Falla, T. J., Karunaratne, D. N. & Hancock, R. E. W. Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 271, 19298-19303 (1996
34. Loh, B., Grant, C. & Hancock, R. E. W. Use of the fluorescent probe 1-Nphenylnaphthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 26, 546-551 (1984
35. Kalfa, V. C. et al. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells. Antimicrob. Agents Chemother. 45, 3256-3261 (2001
36. Mangoni, M. L. et al. Effects of the antimicrobial peptide temporin L on cell morphology, membrane permeability and viability of Escherichia coli. Biochem. J. 380, 859-865 (2004
37. Bourbon, C. et al. Use of a real-Time polymerase chain reaction thermocycler to study bacterial cell permeabilization by antimicrobial peptides. Anal. Biochem. 381, 279-281 (2008
38. Park, S-C. et al. Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: Pore formation mechanism in various lipid compositions. Biochim. Biophys. Acta Biomembr. 1778, 229-241 (2008
39. Powers, J. P. & Hancock, R. E. The relationship between peptide structure and antibacterial activity. Peptides 24, 1681-1691 (2003
40. Sugiarto, H. & Yu, P-L. Mechanisms of action ofostrich b-defensins against Escherichia coli. FEMS Microbiol. Lett. 270, 195-200 (2007
41. Patrzykat, A., Friedrich, C. L., Zhang, L., Mendoza, V. & Hancock, R. E. W. Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob. Agents Chemother. 46, 605-614 (2002