Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.

International Journal of Antimicrobial Agents

Volumn 32, Issue 2, 2008, Pages 130-138

  Chou, Hung Ta ^a   Kuo, Tsun Yung ^a   Chiang, Jung Chun ^a   Pei, Min Ju ^a   Yang, Wei Ter ^a   Yu, Hui Chun ^a   Lin, Shih Bin ^a   Chen, Wei Jung ^a  

^a NATIONAL ILAN UNIVERSITY   (Taiwan)

Author keywords

Amphipathic; Antimicrobial peptide; Cationic; Helical; Structural parameters; Vibrio

Indexed keywords

POLYPEPTIDE ANTIBIOTIC AGENT;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; NONHUMAN; PRIORITY JOURNAL; VIBRIO;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CIRCULAR DICHROISM; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; VIBRIO;

EID: 46049119398     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2008.04.003     Document Type: Article

References (18)

1. Davies J. Inactivation of antibiotics and the dissemination of resistance genes. Science 264 (1994) 375-382
2. Thomson J.M., and Bonomo R.A. The threat of antibiotic resistance in Gram-negative pathogenic bacteria: beta-lactams in peril. Curr Opin Microbiol 8 (2005) 518-524
3. Hancock R.E.W., and Patrzykat A. Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics. Curr Drug Targets Infect Disord 2 (2002) 79-83
4. Hancock R.E.W., and Sahl H.G. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat Biotechnol 24 (2006) 1551-1557
5. Jenssen H., Hamill P., and Hancock R.E.W. Peptide antimicrobial agents. Clin Microbiol Rev 19 (2006) 491-511
6. Scott M.G., and Hancock R.E.W. Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol 20 (2000) 407-431
7. Hancock R.E.W. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 1 (2001) 156-164
8. Dathe M., and Wieprecht T. Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells. Biochim Biophys Acta 1462 (1999) 71-87
9. Hancock R.E.W., and Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol 16 (1998) 82-88
10. Friedrich C.L., Rozek A., Patrzykat A., and Hancock R.E.W. Structure and mechanism of action of an indolicidin peptide derivative with improved activity against Gram-positive bacteria. J Biol Chem 276 (2001) 24015-24022
11. Chen Y., Mant C.T., Farmer S.W., Hancock R.E.W., Vasil M.L., and Hodges R.S. Rational design of α-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem 280 (2005) 12316-12329
12. Zelezetsky I., and Tossi A. Alpha-helical antimicrobial peptides-using a sequence template to guide structure-activity relationship studies. Biochim Biophys Acta 1758 (2006) 1436-1449
13. Syvitski R.T., Burton I., Mattatal V.R., Douglas S.E., and Jakeman D.L. Structural characterization of the antimicrobial peptide pleurocidin from winter flounder. Biochemistry 44 (2005) 7282-7293
14. Eisenberg D., Weiss R.M., and Terwilliger T.C. The hydrophobic moment detects periodicity in protein hydrophobicity. Proc Natl Acad Sci U S A 81 (1984) 140-144
15. Chen W.J., Huang P.T., Liu J., and Liao T.H. Involvement of the N- and C-terminal fragments of bovine pancreatic deoxyribonuclease in active protein folding. Biochemistry 43 (2004) 10653-10663
16. Chen W.J., Lee I.S., Chen C.Y., and Liao T.H. Biological functions of the disulfides in bovine pancreatic deoxyribonuclease. Protein Sci 13 (2004) 875-883
17. Chen Y.H., Yang J.T., and Chau K.H. Determination of the helix and beta form of proteins in aqueous solution by circular dichroism. Biochemistry 13 (1974) 3350-3359
18. Yoshida K., Mukai Y., Niidome T., Takashi C., Tokunaga Y., Hatakeyama T., et al. Interaction of pleurocidin and its analogs with phospholipid membrane and their antibacterial activity. J Pept Res 57 (2001) 119-126