Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure

FEBS Letters

Volumn 540, Issue 1-3, 2003, Pages 229-233

  Yang, Sung Tae ^a   Shin, Song Yub ^b   Lee, Chul Won ^a   Kim, Yong Chul ^a   Hahm, Kyung Soo ^b   Kim, Jae Il ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Antimicrobial peptide; Arg to Lys substitution; Cell selectivity; Tritrpticin

Indexed keywords

ARGININE DERIVATIVE; ARGINYLARGINYLPHENYLALANYLPROLYLTRYPTOPHYLTRYPTOPHYLTRYPTOPHYLPROLYLPHENYLA LANYLARGINYLARGININE; LIPOSOME; LYSINE DERIVATIVE; LYSYLLYSYLPHENYLALANYLTRYPTOPHYLTRYPTOPHYLTRYPTOPHYLPROLYLPHENYLALANYLLYSYL LYSINE; TRITRPTICIN; UNCLASSIFIED DRUG; VALYLLYSYLLYSYLPHENYLALANYLPROLYLTRYPTOPHYLTRYPTOPHYLTRYTOPHYLPROLYLPHENYLA LANYLLEUCYLLYSYLLYSINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BINDING AFFINITY; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HEMOLYSIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS;

EID: 0344838675     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(03)00266-7     Document Type: Article

References (29)

1. Boman H.G. Annu. Rev. Immunol. 13:1995;61-92.
2. Hancock R.E.W., Lehrer R.I. Trends Biotechnol. 16:1998;82-88.
3. Hwang P.M., Vogel H.J. Biochem. Cell Biol. 76:1998;235-246.
4. Zasloff M. Curr. Opin. Immunol. 4:1992;3-7.
5. Nicolas P., Mor A. Annu. Rev. Microbiol. 49:1995;277-304.
6. Maloy W.L., Kari U.P. Biopolymers. 37:1995;105-122.
7. Hancock R.E.W., Falla T., Brown M. Adv. Microb. Physiol. 37:1995;135-175.
8. Lohner K., Prenner E.J. Biochim. Biophys. Acta. 1462:1999;141-156.
9. Oren Z., Shai Y. J. Biol. Chem. 271:1996;7305-7308.
10. Shin S.Y., Kang J.H., Jang S.Y., Kim Y., Kim K.L., Hahm K.S. Biochim. Biophys. Acta. 1463:2000;209-218.
11. Oh D., Shin S.Y., Lee S., Kang J.H., Kim S.D., Ryu P.D., Hahm K.S., Kim Y. Biochemistry. 39:2000;11855-11864.
12. Hong J., Oren Z., Shai Y. Biochemistry. 38:1999;16963-16973.
13. Subbalakshmi C., Krishnakumari V., Nagaraj R., Sitaram N. FEBS Lett. 395:1996;48-52.
14. Blondelle S.E., Houghten R.A. Biochemistry. 30:1991;4671-4678.
15. Dathe M., Meyer J., Beyermann M., Maul B., Hoischen C., Bienert M. Biochim. Biophys. Acta. 1558:2002;171-186.
16. Dathe M., Nikolenko H., Meyer J., Beyermann M., Bienert M. FEBS Lett. 501:2001;146-150.
17. Castano S., Cornut I., Buttner K., Dasseux J.L., Dufourcq J. Biochim. Biophys. Acta. 1416:1999;161-175.
18. Tossi A., Sandri L., Giangaspero A. Biopolymers. 55:2000;4-30.
19. Lawyer C., Pai S., Watabe M., Borgia P., Mashimo T., Eagleton L., Watabe K. FEBS Lett. 390:1996;95-98.
20. Schibli D.J., Hwang P.M., Vogel H.J. Biochemistry. 38:1999;16749-16755.
21. Yang S.T., Shin S.Y., Kim Y., Kim Y.C., Hahm K.S., Kim J. Biochem. Biophys. Res. Commun. 296:2002;1044-1050.
22. Nagpal S., Gupta V., Kaur K.J., Salunke D.M. J. Biol. Chem. 274:1999;23296-23304.
23. Muhle S.A., Tam J.P. Biochemistry. 40:2001;5777-5785.
24. Tokunaga Y., Niidome T., Hatakeyama T., Aoyagi H. J. Pept. Sci. 7:2001;297-304.
25. Chen J., Falla T.J., Liu H., Hurst M.A., Fujii C.A., Mosca D.A., Embree J.R., Loury D.J., Radel P.A., Cheng Chang C., Gu L., Fiddes J.C. Biopolymers. 55:2000;88-98.
26. Matsuzaki K., Sugishita K., Ishibe N., Ueha M., Nakata S., Miyajima K., Epand R.M. Biochemistry. 37:1998;11856-11863.
27. Tytler E.M., Segrest J.P., Epand R.M., Nie S.Q., Epand R.F., Mishra V.K., Venkatachalapathi Y.V., Anantharamaiah G.M. J. Biol. Chem. 268:1993;22112-22118.
28. Vogel H.J., Schibli D.J., Jing W., Lohmeier-Vogel E.M., Epand R.F., Epand R.M. Biochem. Cell Biol. 80:2002;49-63.
29. Rozek A., Friedrich C.L., Hancock R.E.W. Biochemistry. 39:2000;15765-15774.