High-sweat Na + in cystic fibrosis and healthy individuals does not diminish thirst during exercise in the heat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 4, 2011, Pages

  Brown, M B ^a   McCarty, N A ^b   Millard Stafford, M ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Eccrine; Osmolality; Plasma volume; Salt; Thermoregulation

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; SODIUM CHLORIDE; SODIUM ION; VASOPRESSIN;

ADULT; ALDOSTERONE BLOOD LEVEL; ANGIOTENSIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DEHYDRATION; DRINKING; ELECTROLYTE DISTURBANCE; EXERCISE; FEMALE; FLUID INTAKE; HEAT; HUMAN; HYPEROSMOLALITY; HYPOVOLEMIA; MALE; PHYSICAL ACTIVITY; PLASMA VOLUME; PRIORITY JOURNAL; SERUM OSMOLALITY; SWEAT; THIRST; VASOPRESSIN BLOOD LEVEL;

ADULT; ALDOSTERONE; ANGIOTENSIN II; BODY WEIGHT; CASE-CONTROL STUDIES; CYSTIC FIBROSIS; DEHYDRATION; EXERCISE; FEMALE; HOT TEMPERATURE; HUMANS; MALE; OSMOLAR CONCENTRATION; PLASMA VOLUME; SODIUM; SWEAT; THIRST; VASOPRESSINS;

EID: 80053642576     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00551.2010     Document Type: Article

References (48)

1. Allan JR, Wilson CG. Influence of acclimatization on sweat sodium concentration. J Appl Physiol 30: 708-712, 1971.
2. Amatruda TTJ, Welt LG. Secretion of electrolytes in thermal sweat. J Appl Physiol 5: 759-772, 1953.
3. Antunes-Rodrigues J, De Castro M, Elias LLK, Valenca MM, Mc-Cann SM. Neuroendocrine control of body fluid metabolism. Physiol Rev 84: 169-208, 2004.
4. Armstrong L, Maresh C, Castellani J, Bergeron M, Kenefick R, La Gasse K, Riebe D. Urinary indices of hydration status. Int J Sport Nutr Exerc Metab 4: 265-279, 1994.
5. Baker LB, Stofan JR, Hamilton AA, Horswill CA. Comparison of regional patch collection vs. whole body washdown for measuring sweat sodium and potassium loss during exercise. J Appl Physiol 107: 887-895, 2009.
6. Bar-Or O, Blimkie C, Hay J, MacDougall J, Ward D, Wilson W. Voluntary dehydration and heat intolerance in cystic fibrosis. Lancet 339: 696-699, 1992.
7. Borg G. Perceived exertion: a note on "history" and methods. Med Sci Sports Exerc 19: 398-403, 1987.
8. Brisson GR. A simple and disposable sweat collector. Eur J Appl Physiol 63: 269-272, 1991.
9. Brown MB, Haack KKV, Pollack BP, Millard-Stafford M, McCarty NA. Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise. Am J Physiol Regul Integr Comp Physiol 300: R605-R615, 2011.
10. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37: 247-248, 1974.
11. Emrich HM, Stoll E, Friolet B, Colombo JP, Richterich R, Rossi E. Sweat composition in relation to rate of sweating in patients with cystic fibrosis of the pancreas. Pediatr Res 2: 464-478, 1968.
12. Engell D, Maller O, Sawka MN, Francesconi N, Drolet L, Young AJ. Thirst and fluid intake following graded hypohyration levels in humans. Physiol Behav 40: 229-236, 1987.
13. Fitzsimons JT. Angiotensin, thirst, and sodium appetite. Physiol Rev 78: 583-686, 1998.
14. Fitzsimons JT. Drinking by rats depleted of body fluid without increase in osmotic pressure. J Physiol 159: 297-309, 1961.
15. Greenleaf JE. Problem: thirst, drinking behavior, and involuntary dehydration. Med Sci Sports Exerc 24: 645-656, 1992.
16. Greenleaf JE, Sargent F. Voluntary dehydration in man. J Appl Physiol 20: 719-724, 1965.
17. Johnson A. The sensory psychobiology of thirst and salt appetite. Med Sci Sports Exerc 39: 1388-1400, 2007.
18. Kenefick R, St. Pierre A, Riel N, Cheuvront S, Castellani J. Effect of increased plasma osmolality on cold-induced thirst attenuation. Eur J Appl Physiol 104: 1013-1019, 2008.
19. Kirby CR, Convertino VA. Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. J Appl Physiol 61: 967-970, 1986.
20. Kriemler S, Wilk B, Schurer W, Wilson W, Bar-Or O. Preventing dehydration in children with cystic fibrosis who exercise in the heat. Med Sci Sports Exerc 31: 774-779, 1999.
21. Maresh CM, Gabaree-Boulant CL, Armstrong LE, Judelson DA, Hoffman JR, Castellani JW, Kenefick RW, Bergeron MF, Casa DJ. Effect of hydration status on thirst, drinking, and related hormonal responses during low-intensity exercise in the heat. J Appl Physiol 97: 39-44, 2004.
22. McKinley MJ, Johnson AK. The physiological regulation of thirst and fluid intake. Physiology 19: 1-6, 2004.
23. Montain S, Cheuvront SN, Lukaski H. Sweat mineral element responses during 7 hr of exercise-heat stress. Int J Sport Nutr Exerc Metab 17: 574-582, 2007.
24. Montain SJ, Cheuvront SN, Sawka MN. Exercise associated hyponatremia: quantitative analysis to understand the aetiology. Br J Sports Med 40: 98-106, 2006.
25. Morgan R, Patterson M, Nimmo M. Acute effects of dehydration on sweat composition in men during prolonged exercise in the heat. Acta Physiol Scand 182: 37-43, 2004.
26. Nielsen B, Strange S, Christensen N, Warberg J, Salin B. Acute and adaptive responses in humans to exercise in a warm, humid environment. Pflugers Arch-Eur J Physiol 434: 49-56, 1997.
27. Nixon PA. Role of exercise in the evaluation and management of pulmonary disease in children and youth. Med Sci Sports Exerc 28: 414-420, 1996.
28. Nixon PA, Orenstein DM. The prognostic value of exercise testing in patients with cystic fibrosis (Abstract). N Engl J Med 327: 1785, 1992.
29. Noda M. The subfornical organ, a specialized sodium channel, and the sensing of sodium levels in the brain. Neuroscientist 12: 80-91, 2006.
30. Nose H, Mack GW, Shi X, Nadel ER. Shift in body fluid compartments after dehydration in humans. J Appl Physiol 65: 318-324, 1988.
31. Nose H, Yawata T, Morimoto T. Osmotic factors in restitution from thermal dehydration in rats. Am J Physiol Regul Integr Comp Physiol 249: R166-R171, 1985.
32. Orenstein D, Henke K, Costill D, Doershuk C, Lemon P, Stern R. Exercise and heat stress in cystic fibrosis patients. Ped Res 17: 267-269, 1983.
33. Orenstein DM, Henke KG, Green CG. Heat acclimation in cystic fibrosis. J Appl Physiol 57: 408-412, 1984.
34. Patterson MJ. Variations in regional sweat composition in normal human males. Exp Physiol 85: 869-875, 2000.
35. Phillips PA, Rolls BJ, Ledingham JG, Forsling ML, Morton JJ. Osmotic thirst and vasopressin release in humans: a double-blind crossover study. Am J Physiol Regul Integr Comp Physiol 248: R645-R650, 1985.
36. +concentrations in cystic fibrosis eccrine sweat in vivo and in vitro. J Lab Clin Med 115: 504-511, 1990.
37. Sawka M, Burke L, Eichner E, Maughan R, Montain S, Stachenfeld N. American College of Sports Medicine position stand. Exercise and fluid replacement. Med Sci Sports Exerc 39: 377-390, 2007.
38. Shirreffs SM, Maughan RJ. Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content. J Appl Physiol 82: 336-341, 1997.
39. Shwachman H, Mahmoodian A. Pilocarpine iontophoresis sweat testing results of seven years' experience. Mod Probl Pediat 10: 158-182, 1966.
40. Shwachman H, Mahmoodian A, Neff RK. The sweat test: sodium and chloride values (Abstract). J Pediatr 98: 576, 1981.
41. Skott O. Body sodium and volume homeostasis. Am J Physiol Regul Integr Comp Physiol 285: R14-R18, 2003.
42. Smiles KA, Robinson S. Sodium ion conservation during acclimatization of men to work in the heat. J Appl Physiol 31: 63-69, 1971.
43. Smith HR, Dhatt GS. Cystic fibrosis presenting as hyponatraemic heat exhaustion. Br Med J 310: 579-580, 1995.
44. Stachenfeld NS. Acute effects of sodium ingestion on thirst and cardiovascular function. Curr Sports Med Rep 7: S7-S13, 2008.
45. Stricker E, Callahan J, Huang W, Sved A. Osmoregulation in waterdeprived rates drinking hypertonic saline: effect of area postrema lesions. Am J Physiol Regul Integr Comp Physiol 280: R831-R842, 2001.
46. Turchetta A, Salerno T, Lucidi V, Libera F, Cutrera R, Bush A. Usefulness of a program of hospital-supervised physical training in patients with cystic fibrosis. Pediatr Pulmonol 38: 115-118, 2004.
47. Volkes T, Weiss N, Schreiber J, Gaskill M, Robertson G. Osmoregulation of thirst and vasopressin during normal menstrual cycle. Am J Physiol Regul Integr Comp Physiol 232: R461-R647, 1977.
48. Weschler LB. Sweat electrolyte concentrations obtained from within occlusive coverings are falsely high because sweat itself leaches skin electrolytes. J Appl Physiol 105: 1376-1377, 2008.