The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization

Journal of Molecular Biology

Volumn 426, Issue 8, 2014, Pages 1848-1860

  Prota, Andrea E ^a   Danel, Franck ^b   Bachmann, Felix ^b   Bargsten, Katja ^a   Buey, Rubén M ^a   Pohlmann, Jens ^b   Reinelt, Stefan ^b   Lane, Heidi ^b   Steinmetz, Michel O ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

biochemistry; microtubule targeting drugs; molecular mechanism; tubulin; X ray crystallography

Indexed keywords

ANTINEOPLASTIC AGENT; BAL 27862; COLCHICINE; PROTEINASE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; BINDING COMPETITION; BINDING KINETICS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEPOLYMERIZATION; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; IC 50; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

BIOCHEMISTRY; MICROTUBULE-TARGETING DRUGS; MOLECULAR MECHANISM; TUBULIN; X-RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BINDING SITES; BINDING, COMPETITIVE; CATTLE; CELL LINE, TUMOR; COLCHICINE; CRYSTALLOGRAPHY, X-RAY; HELA CELLS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MODELS, MOLECULAR; OXADIAZOLES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; TUBULIN; TUBULIN MODULATORS; VINBLASTINE;

EID: 84897109910     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.02.005     Document Type: Article

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