Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography

European Journal of Biochemistry

Volumn 270, Issue 18, 2003, Pages 3822-3828

  Cruz Monserrate, Zobeida ^a   Mullaney, Jeffrey T ^b   Harran, Patrick G ^c   Pettit, George R ^b   Hamel, Ernest ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cemadotin; Cryptophycin 1; Dolastatin 10; Dolastatin 15; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; BETA TUBULIN; CEMADOTIN; COLCHICINE DERIVATIVE; COMBRETASTATIN A4; CRYPTOPHYCIN DERIVATIVE; DEPSIPEPTIDE; DIAZONAMIDE A; DOLASTATIN 10; DOLASTATIN 15; HALICHONDRIN B; LIGAND; PEPTIDE; PHOMOPSIN A; TRITIUM; UNCLASSIFIED DRUG; VINBLASTINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATTLE; CHROMATOGRAPHY; CYTOTOXICITY; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG PROTEIN BINDING; GEL FILTRATION CHROMATOGRAPHY; ISOTOPE LABELING; LIGAND BINDING; METHODOLOGY; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; BINDING SITES; CATTLE; CHROMATOGRAPHY, GEL; COLCHICINE; DEPSIPEPTIDES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; KINETICS; MAYTANSINE; OLIGOPEPTIDES; OXAZOLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TRITIUM; TUBULIN; VINBLASTINE; VINCRISTINE;

BOS TAURUS; VINCA;

EID: 0141447346     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03776.x     Document Type: Article

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