A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the Chemosensitization of tumor cells to platinum

Chemistry and Biology

Volumn 21, Issue 3, 2014, Pages 398-407

  Alekseev, Sergey ^a   Ayadi, Mériam ^b   Brino, Laurent ^a   Egly, Jean Marc ^a   Larsen, Annette K ^b   Coin, Frédéric ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b CENTRE DE RECHERCHE SAINT ANTOINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLOHEXIMIDE; EPLERENONE; MERBROMIN; OXALIPLATIN; PROTEASOME; SPIRONOLACTONE; TRANSCRIPTION FACTOR IIH; UBIQUITIN PROTEIN LIGASE; ANTINEOPLASTIC AGENT; ATP DEPENDENT 26S PROTEASE; PROTEIN SUBUNIT;

ARTICLE; CHEMOSENSITIZATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG REPOSITIONING; EXCISION REPAIR; FEMALE; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERTANT; CELL SURVIVAL; CHEMISTRY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; HCT116 CELL LINE; HELA CELL LINE; METABOLISM; PROTEIN SUBUNIT; RADIATION RESPONSE; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DNA DAMAGE; DNA REPAIR; DOWN-REGULATION; HCT116 CELLS; HELA CELLS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; SPIRONOLACTONE; TRANSCRIPTION FACTOR TFIIH; TRANSCRIPTION, GENETIC; UBIQUITIN-ACTIVATING ENZYMES; ULTRAVIOLET RAYS;

EID: 84897090306     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.12.014     Document Type: Article

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