In situ product removal in fermentation systems: Improved process performance and rational extractant selection

Biotechnology Letters

Volumn 36, Issue 3, 2014, Pages 443-460

  Dafoe, Julian T ^a   Daugulis, Andrew J ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Absorption; Adsorption; Biocatalysis; Extractive fermentation; Ionic liquids; Product removal (in situ); Reactive extraction

Indexed keywords

ABSORPTION; ADSORPTION; EXTRACTION; IONIC LIQUIDS;

BIOCATALYSIS; EXTRACTIVE FERMENTATION; FERMENTATION PERFORMANCE; FERMENTATION SYSTEMS; INHIBITORY COMPOUNDS; PROCESSING STRATEGIES; PRODUCT REMOVAL (IN SITU); REACTIVE EXTRACTION;

FERMENTATION;

BIOLOGICAL PRODUCT; SOLVENT;

BIOTECHNOLOGY; BIOTRANSFORMATION; FERMENTATION; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; REVIEW;

BIOLOGICAL PRODUCTS; BIOTECHNOLOGY; BIOTRANSFORMATION; FERMENTATION; SOLVENTS;

EID: 84897089872     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-013-1380-6     Document Type: Review

References (67)

1. Anvari M, Khayati G (2009) In situ recovery of 2, 3-butanediol from fermentation by liquid-liquid extraction. J Ind Microbiol Biotechnol 36: 313-317.
2. Barton WE, Daugulis AJ (1992) Evaluation of solvents for extractive butanol fermentation with Clostridiumacetobutylicum and the use of poly (propylene glycol) 1200. Appl Microbiol Biotechnol 36: 632-639.
3. Boghigian BA, Myint M, Wu J, Pfeifer BA (2011) Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. J Ind Microbiol Biotechnol 38: 1809-1820.
4. Boontawan P, Kanchanathawee S, Boontawan A (2011) Extractive fermentation of l-(+)-lactic acid by Pediococcus pentosaceus using electrodeionization (EDI) technique. Biochem Eng J 54: 192-199.
5. Brennan TC, Turner CD, Krömer JO, Nielsen LK (2012) Alleviating monoterpene toxicity using a two-phase extractive fermentation for the bioproduction of jet fuel mixtures in Saccharomyces cerevisiae. Biotechnol Bioeng 109: 2513-2522.
6. Chavez-Santoscoy A, Benavides J, Vermaas W, Rito-Palomares M (2010) Application of aqueous two-phase systems for the potential extractive fermentation of cyanobacterial products. Chem Eng Technol 33: 177-182.
7. Choi JM, Yeom SH (2011) Simulation study of biobutanol production in a polymer-loaded two-phase partitioning bioreactor (PL-TPPB): model development. Korean J Chem Eng 28: 2170-2177.
8. Craig T, Daugulis AJ (2012) Polymer characterization and optimization of conditions for the enhanced bioproduction of benzaldehyde by Pichia pastoris in a two-; phase partitioning bioreactor. Biotechnol Bioeng 110: 1098-1105.
9. Dafoe JTS, Daugulis AJ (2011) Bioproduction of cis-(1S, 2R)-indandiol, a chiral pharmaceutical intermediate, using a solid-liquid two-phase partitioning bioreactor for enhanced removal of inhibitors. J Chem Technol Biotechnol 86: 1379-1385.
10. Dafoe JT, Daugulis AJ (2013a) Production of 4-valerolactone by an equilibrium-limited transformation in a partitioning bioreactor: impact of absorptive polymer properties. Bioprocess Biosyst Eng. doi: 10. 1007/s00449-013-1020-5.
11. Dafoe JT, Daugulis AJ (2013b) Manipulating the composition of absorbent polymers affects product and by-product concentration profiles in the biphasic biotransformation of indene to cis-1, 2-indandiol. Biochem Eng J 77: 7-14.
12. Dhamole PB, Wang Z, Liu Y, Wang B, Feng H (2012) Extractive fermentation with non-ionic surfactants to enhance butanol production. Biomass Bioenergy 40: 112-119.
13. Fam H, Daugulis AJ (2012) Substrate mass transport in two-phase partitioning bioreactors employing liquid and solid non-aqueous phases. Bioprocess Biosyst Eng 35: 1367-1374.
14. Galaction A, Poştaru M, Caşcaval D, Kloetzer L (2013) Selective separation of carboxylic acids obtained by succinic acid fermentation using facilitated pertraction. Solvent Extr Ion Exch 31: 171-183.
15. Gao F, Daugulis AJ (2009) Bioproduction of the aroma compound 2-phenylethanol in a solid-liquid two-phase partitioning bioreactor system by Kluyveromyces marxianus. Biotechnol Bioeng 104: 332-339.
16. Gao MT, Shimamura T, Ishida N, Takahashi H (2011) pH-uncontrolled lactic acid fermentation with activated carbon as an adsorbent. Enzyme Microb Technol 48: 526-530.
17. Garcia-Chavez LY, Garsia CM, Schuur B, de Haan AB (2013) Bio-butanol recovery using non-fluorinated task specific ionic liquids (TSILs). Ind Eng Chem Res 52: 4902-4910.
18. Garikipati SJ, McIver AM, Peeples TL (2009) Whole-cell biocatalysis for 1-naphthol production in liquid-liquid biphasic systems. Appl Environ Microbiol 75: 6545-6552.
19. Grady MC, Jahic M, Patnaik R (2010) Method for producing butanol using two-phase extractive fermentation. Patent application US 20100221802 A1.
20. Hu Q, Xu Y, Nie Y (2010) Enhancement of Candida parapsilosis catalyzing deracemization of (R, S)-1-phenyl-1, 2-ethanediol to its (S)-enantiomer by a highly productive "two-in-one" resin-based in situ product removal strategy. Bioresour Technol 101: 8461-8463.
21. Hu Z, Zhang X, Wu Z, Qi H, Wang Z (2012) Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution. Appl Microbiol Biotechnol 94: 81-89.
22. Hua D, Lin S, Li Y, Chen H, Zhang Z, Du Y, Zhang X, Xu P (2010) Enhanced 2-phenylethanol production from l-phenylalanine via in situ product adsorption. Biocatal Biotransfor 28: 259-266.
23. Jain AN, Khan TR, Daugulis AJ (2010) Bioproduction of benzaldehyde in a solid-liquid two-phase partitioning bioreactor using Pichia pastoris. Biotechnol Lett 32: 1649-1654.
24. Jeon BS, Moon C, Kim B, Kim H, Um Y, Sang B (2013) In situ extractive fermentation for the production of hexanoic acid from galactitol by Clostridium sp. BS-1. Enzyme Microb Technol 53: 143-151.
25. Jeong G, Kim S, Park D (2013) Detoxification of hydrolysate by reactive-extraction for generating biofuels. Biotechnol Bioprocess Eng 18: 88-93.
26. Jin H, Liu Z, Hu Z, Zheng Y (2013) Production of (R)-epichlorohydrin from 1, 3-dichloro-2-propanol by two-step biocatalysis using haloalcohol dehalogenase and epoxide hydrolase in two-phase system. Biochem Eng J 74: 1-7.
27. Julsing MK, Kuhn D, Schmid A, Bühler B (2012) Resting cells of recombinant E. coli show high epoxidation yields on energy source and high sensitivity to product inhibition. Biotechnol Bioeng 109: 1109-1119.
28. Jung D, Choi W, Choi K, Jung E, Yun H, Kazlauskas RJ, Kim B (2013) Bioconversion of p-coumaric acid to p-hydroxystyrene using phenolic acid decarboxylase from B. amyloliquefaciens in biphasic reaction system. Appl Microbiol Biotechnol 97: 1501-1511.
29. Keasler SJ, Lewin JL, Schultz NE, Ross RB, Gryska NM, Nakamura M, Siepmann JI (2013) Molecular insights for the optimization of solvent-based selective extraction of ethanol from fermentation broths. AIChE J 59: 3065-3070.
30. Khan TR, Daugulis AJ (2010) Application of solid-liquid TPPBs to the production of l-phenylacetylcarbinol from benzaldehyde using Candida utilis. Biotechnol Bioeng 107: 633-641.
31. Krug TA, Daugulis AJ (1983) Ethanol production using Zymomonas mobilis immobilized on an ion exchange resin. Biotechnol Lett 5: 159-164.
32. Kuhn D, Julsing MK, Heinzle E, Bühler B (2012) Systematic optimization of a biocatalytic two-liquid phase oxyfunctionalization process guided by ecological and economic assessment. Green Chem 14: 645-653.
33. Leeman M, Vossebeld F, Visser TJ, Schuur B, de Haan AB (2013) Novel extractants for the recovery of fermentation derived lactic acid. Sep Purif Technol 111: 82-89.
34. Li Q, Cai H, Hao B, Zhang C, Yu Z, Zhou S, Chenjuan L (2010) Enhancing clostridial acetone-butanol-ethanol (ABE) production and improving fuel properties of ABE-enriched biodiesel by extractive fermentation with biodiesel. Appl Biochem Biotechnol 162: 2381-2386.
35. Li Q, Wang D, Hu G, Xing J, Su Z (2011a) Integrated bioprocess for high-efficiency production of succinic acid in an expanded-bed adsorption system. Biochem Eng J 56: 150-157.
36. Li SY, Srivastava R, Parnas RS (2011b) Study of in situ 1-butanol pervaporation from A-B-E fermentation using a PDMS composite membrane: validity of solution-diffusion model for pervaporative A-B-E fermentation. Biotechnol Prog 27: 111-120.
37. Liu S, Wu Q, Zhang J, Mo S (2011) Production of epsilon-poly-l-lysine by Streptomyces sp. using resin-based, in situ product removal. Biotechnol Lett 33: 1581-1585.
38. Mao S, Hua B, Wang N, Hu X, Ge Z, Li Y, Liu S, Lu F (2012) 11α hydroxylation of 16α, 17-epoxypro-gesterone in biphasic ionic liquid/water system by Aspergillus ochraceus. J Chem Technol Biotechnol 88: 287-292.
39. Mei J, Min H, Lü Z (2009) Enhanced biotransformation of l-phenylalanine to 2-phenylethanol using an in situ product adsorption technique. Proc Biochem 44: 886-890.
40. Mihal M, Markoš J, Annus J, Štefuca V (2012) Intensification of 1-phenylethanol production by periodical membrane extraction of the product from fermentation broth. J Chem Technol Biot 87: 1017-1026.
41. Mirata MA, Heerd D, Schrader J (2009) Integrated bioprocess for the oxidation of limonene to perillic acid with Pseudomonas putida DSM 12264. Proc Biochem 44: 764-771.
42. Muñoz R, Daugulis AJ, Hernández M, Quijano G (2012) Recent advances in two-phase partitioning bioreactors for the treatment of volatile organic compounds. Biotechnol Adv 30: 1707-1720.
43. Neves CMSS, Granjo JFO, Freire MG, Robertson A, Oliveira NMC, Coutinho JAP (2011) Separation of ethanol-water mixtures by liquid-liquid extraction using phosphonium-based ionic liquids. Green Chem 13: 1517-1526.
44. Nielsen DR, Amarasiriwardena GS, Prather KLJ (2010) Predicting the adsorption of second-generation biofuels by polymeric resins with applications for in situ product recovery (ISPR). Bioresour Technol 101: 2762-2769.
45. Oudshoorn A, van der Wielen LAM, Straathof AJJ (2009) Assessment of options for selective 1-butanol recovery from aqueous solution. Ind Eng Chem Res 48: 7325-7336.
46. Pahlavanzadeh H, Khayati G, Vasheghani-Farahani E, Ghaemi N (2009) Extractive capacity of oleyl alcohol on 2, 3-butanediol production in fermentation process with use of Klebsiella pneumoniae PTCC 1290. Iran J Chem Chem Eng -Int Engl Ed 28: 103-109.
47. Parent JS, Capela M, Dafoe JT, Daugulis AJ (2012) A first principles approach to identifying polymers for use in two-phase partitioning bioreactors. J Chem Technol Biotechnol 87: 1059-1065.
48. Poleo EE, Daugulis AJ (2013) A comparison of three first principles methods for predicting solute-polymer affinity, and the simultaneous biodegradation of phenol and butyl acetate in a two-phase partitioning bioreactor. J Chem Technol Biotechnol. doi: 10. 1002/jctb. 4116.
49. Quijano G, Hernandez M, Villaverde S, Thalasso F, Muñoz R (2010) A step-forward in the characterization and potential applications of solid and liquid oxygen transfer vectors. Appl Microbiol Biotechnol 85: 543-551.
50. Ranjan R, Thust S, Gounaris CE, Woo M, Floudas CA, Keitz MV, Valentas KJ, Wei J, Tsapatsis M (2009) Adsorption of fermentation inhibitors from lignocellulosic biomass hydrolyzates for improved ethanol yield and value-added product recovery. Microporous Mesoporous Mater 122: 143-148.
51. Redwood MD, Orozco RL, Majewski AJ, Macaskie LE (2012) Electro-extractive fermentation for efficient biohydrogen production. Bioresour Technol 107: 166-174.
52. Rehmann L, Daugulis AJ (2007) Biodegradation of biphenyl in a solid-liquid two-phase partitioning bioreactor. Biochem Eng J 36: 195-201.
53. Rong S, Ding B, Zhang X, Zheng X, Wang Y (2011) Enhanced biotransformation of 2-phenylethanol with ethanol oxidation in a solid-liquid two-phase system by active dry yeast. Curr Microbiol 63: 503-509.
54. Ruetti DP, Lacroix C, Jeremic T, Mathis M, Die A, Vollenweider S (2011) Development of a reversible binding process for in situ removal of 3-hydroxypropionaldehyde during biotechnological conversion of glycerol. Biochem Eng J 55: 176-184.
55. Tanaka S, Tashiro Y, Kobayashi G, Ikegami T, Negishi H, Sakaki K (2012) Membrane-assisted extractive butanol fermentation by Clostridium saccharoperbutylacetonicum N1-4 with 1-dodecanol as the extractant. Bioresour Technol 116: 448-452.
56. van den Berg C, Heeres AS, van der Wielen LA, Straathof AJ (2013) Simultaneous clostridial fermentation, lipase-catalyzed esterification, and ester extraction to enrich diesel with butyl butyrate. Biotechnol Bioeng 110: 137-142.
57. Verhoef S, Wierckx N, Westerhof R, De Winde JH, Ruijssenaars HJ (2009) Bioproduction of p-hydroxystyrene from glucose by the solvent-tolerant bacterium Pseudomonas putida S12 in a two-phase water-decanol fermentation. Appl Environ Microbiol 75: 931-936.
58. Wang Z, Liang R, Xu J, Liu Y, Qi H (2010) A closed concept of extractive whole cell Microbial transformation of benzaldehyde into l-phenylacetylcarbinol by Saccharomyces cerevisiae in novel polyethylene-glycol-induced cloud-point system. Appl Biochem Biotechnol 160: 1865-1877.
59. Wang H, Dong Q, Guan A, Meng C, Shi X, Guo Y (2011a) Synergistic inhibition effect of 2-phenylethanol and ethanol on bioproduction of natural 2-phenylethanol by Saccharomyces cerevisiae and process enhancement. J Biosci Bioeng 112: 26-31.
60. Wang H, Dong Q, Meng C, Guo Y (2011b) A continuous and adsorptive bioprocess for efficient production of the natural aroma chemical 2-phenylethanol with yeast. Enzyme Microb Technol 48: 404-407.
61. Wang P, Wang Y, Su Z (2012a) Microbial production of propionic acid with Propionibacterium freudenreichii using an anion exchanger-based in situ product recovery (ISPR) process with direct and indirect contact of cells. Appl Biochem Biotechnol 166: 1-13.
62. Wang P, Wang Y, Liu Y, Shi H, Su Z (2012b) Novel in situ product removal technique for simultaneous production of propionic acid and vitamin B12 by expanded bed adsorption bioreactor. Bioresour Technol 104: 652-659.
63. Wei G, Yang X, Zhou W, Lin J, Wei D (2009) Adsorptive bioconversion of ethylene glycol to glycolic acid by Gluconobacter oxydans DSM 2003. Biochem Eng J 47: 127-131.
64. Xue Y, Liu Z, Xu M, Wang Y, Zheng Y, Shen Y (2010) Enhanced biotransformation of (R, S)-mandelonitrile to (R)-(-)-mandelic acid with in situ production removal by addition of resin. Biochem Eng J 53: 143-149.
65. Xue C, Zhao J, Lu C, Yang S, Bai F, Tang I (2012) High-titer n-butanol production by Clostridium acetobutylicum JB200 in fed-batch fermentation with intermittent gas stripping. Biotechnol Bioeng 109: 2746-2756.
66. Zou S, Du E, Hu Z, Zheng Y (2013) Enhanced biotransformation of 1, 3-dichloro-2-propanol to epichlorohydrin via resin-based in situ product removal process. Biotechnol Lett 35: 937-942.
67. Zúñiga C, Morales M, Le Borgne S, Revah S (2011) Production of poly-β-hydroxybutyrate (PHB) by Methylobacteriumorganophilum isolated from a methanotrophic consortium in a two-phase partition bioreactor. J Hazard Mater 190: 876-882.