메뉴 건너뛰기




Volumn 31, Issue 4, 2014, Pages 923-945

Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: Part I. formulation development, statistical optimization, and in vitro characterization

Author keywords

dual drug loading; lyophilization; quercetin; SNEDDS; tamoxifen

Indexed keywords

AEROSIL; ALCOHOL; CAPTEX; COSURFACTANT; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; ETHYLENE GLYCOL; GELUCIRE; LABRAFIL 1944 CS; OCTANOIN; PACEOL; PLUROL; POLOXAMER; POLYSORBATE 20; POLYSORBATE 40; POLYSORBATE 60; POLYSORBATE 80; PROPYLENE GLYCOL; QUERCETIN; TAMOXIFEN; UNCLASSIFIED DRUG; EMULSIFYING AGENT; NANOPARTICLE;

EID: 84897067828     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1213-2     Document Type: Article
Times cited : (71)

References (62)
  • 1
    • 0037364074 scopus 로고    scopus 로고
    • Tamoxifen: A most unlikely pioneering medicine
    • 1:CAS:528:DC%2BD3sXhsFKrtL0%3D 12612646 10.1038/nrd1031
    • Jordan VC. Tamoxifen: a most unlikely pioneering medicine. Nat Rev Drug Discov. 2003;2(3):205-13.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.3 , pp. 205-213
    • Jordan, V.C.1
  • 2
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • 1:CAS:528:DC%2BD3MXislWktw%3D%3D 11121513
    • Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52(4):673-751.
    • (2000) Pharmacol Rev , vol.52 , Issue.4 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 3
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • Boots AW, Haenen G, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2-3):325-37.
    • (2008) Eur J Pharmacol , vol.585 , Issue.2-3 , pp. 325-337
    • Boots, A.W.1    Haenen, G.2    Bast, A.3
  • 4
    • 0029096256 scopus 로고
    • Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells
    • 1:CAS:528:DyaK2MXnsVGlsLg%3D 7636308 10.1111/1523-1747.ep12317599
    • Piantelli M, Maggiano N, Ricci R, Larocca LM, Capelli A, Scambia G, et al. Tamoxifen and quercetin interact with type II estrogen binding sites and inhibit the growth of human melanoma cells. J Invest Dermatol. 1995;105(2):248-53.
    • (1995) J Invest Dermatol , vol.105 , Issue.2 , pp. 248-253
    • Piantelli, M.1    Maggiano, N.2    Ricci, R.3    Larocca, L.M.4    Capelli, A.5    Scambia, G.6
  • 5
    • 0033873786 scopus 로고    scopus 로고
    • Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
    • 1:CAS:528:DC%2BD3cXlvVyms7o%3D 10918203 10.1002/1097-0215(20000815)87: 4<595: AID-IJC21>3.0.CO;2-5
    • Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, et al. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer. 2000;87(4):595-600.
    • (2000) Int J Cancer , vol.87 , Issue.4 , pp. 595-600
    • Caltagirone, S.1    Rossi, C.2    Poggi, A.3    Ranelletti, F.O.4    Natali, P.G.5    Brunetti, M.6
  • 6
    • 33845363659 scopus 로고    scopus 로고
    • The combination of green tea and tamoxifen is effective against breast cancer
    • 1:CAS:528:DC%2BD28Xht1OgsrnE 16785249 10.1093/carcin/bgl066
    • Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, et al. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis. 2006;27(12):2424-33.
    • (2006) Carcinogenesis , vol.27 , Issue.12 , pp. 2424-2433
    • Sartippour, M.R.1    Pietras, R.2    Marquez-Garban, D.C.3    Chen, H.W.4    Heber, D.5    Henning, S.M.6
  • 7
    • 6944243800 scopus 로고    scopus 로고
    • Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation
    • 1:CAS:528:DC%2BD2cXjvVGnsbY%3D 15067354
    • Ma ZS, Thanh HOAH, Chee Pang NG, Phuc Tien DO, Thanh HN, Hung H. Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation. Int J Oncol. 2004;24(5):1297-304.
    • (2004) Int J Oncol , vol.24 , Issue.5 , pp. 1297-1304
    • Ma, Z.S.1    Thanh, H.2    Chee Pang, N.G.3    Phuc Tien, D.O.4    Thanh, H.N.5    Hung, H.6
  • 8
    • 0036591865 scopus 로고    scopus 로고
    • Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin
    • 1:CAS:528:DC%2BD38XjvVegsr4%3D 12031906 10.1016/S0891-5849(02)00839-0
    • Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radic Biol Med. 2002;32(11):1220-8.
    • (2002) Free Radic Biol Med , vol.32 , Issue.11 , pp. 1220-1228
    • Brookes, P.S.1    Digerness, S.B.2    Parks, D.A.3    Darley-Usmar, V.4
  • 9
    • 84855343368 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage
    • 1:CAS:528:DC%2BC38XlsFCgtg%3D%3D 22056766 10.1016/j.tiv.2011.10.013
    • Liu S, Hou W, Yao P, Li N, Zhang B, Hao L, et al. Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage. Toxicol In Vitro. 2012;26(1):74-80.
    • (2012) Toxicol in Vitro , vol.26 , Issue.1 , pp. 74-80
    • Liu, S.1    Hou, W.2    Yao, P.3    Li, N.4    Zhang, B.5    Hao, L.6
  • 10
    • 74249099331 scopus 로고    scopus 로고
    • Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat
    • 1:CAS:528:DC%2BC3cXhvFaisrw%3D 19504466 10.1002/ptr.2883
    • Gupta C, Vikram A, Tripathi DN, Ramarao P, Jena GB. Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat. Phytother Res. 2010;24(1):119-28.
    • (2010) Phytother Res , vol.24 , Issue.1 , pp. 119-128
    • Gupta, C.1    Vikram, A.2    Tripathi, D.N.3    Ramarao, P.4    Jena, G.B.5
  • 11
    • 84055197880 scopus 로고    scopus 로고
    • Hepatoprotective activity of quercetin against acrylonitrile induced hepatotoxicity in rats
    • 1:CAS:528:DC%2BC3MXhs1CnsrfP 21823216 10.1002/jbt.20406
    • Abo-Salem OM, Abd-Ellah MF, Ghonaim MM. Hepatoprotective activity of quercetin against acrylonitrile induced hepatotoxicity in rats. J Biochem Mol Toxicol. 2011;25(6):386-92.
    • (2011) J Biochem Mol Toxicol , vol.25 , Issue.6 , pp. 386-392
    • Abo-Salem, O.M.1    Abd-Ellah, M.F.2    Ghonaim, M.M.3
  • 12
    • 34447514189 scopus 로고    scopus 로고
    • Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen induced protein oxidation and lipid peroxidation
    • 1:CAS:528:DC%2BD2sXot1Wgs7c%3D 17623883 10.1002/jbt.20167
    • Tabassum H, Parvez S, Rehman H, Banerjee BD, Raisuddin S. Catechin as an antioxidant in liver mitochondrial toxicity: inhibition of tamoxifen induced protein oxidation and lipid peroxidation. J Biochem Mol Toxicol. 2007;21(3):110-7.
    • (2007) J Biochem Mol Toxicol , vol.21 , Issue.3 , pp. 110-117
    • Tabassum, H.1    Parvez, S.2    Rehman, H.3    Banerjee, B.D.4    Raisuddin, S.5
  • 13
    • 33751082422 scopus 로고    scopus 로고
    • Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2)
    • 1:CAS:528:DC%2BD28XhtFGqtLnL 17056790
    • Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr. 2006;136(11):2715-21.
    • (2006) J Nutr , vol.136 , Issue.11 , pp. 2715-2721
    • Granado-Serrano, A.B.1    Martin, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 14
    • 0031183507 scopus 로고    scopus 로고
    • Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer
    • 1:CAS:528:DyaK2sXksF2ktLk%3D 9224209 10.1165/ajrcmb.17.1.2728
    • Caltagirone S, Ranelletti FO, Rinelli A, Maggiano N, Colasante A, Musiani P, et al. Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer. Am J Respir Cell Mol Biol. 1997;17(1):51-9.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , Issue.1 , pp. 51-59
    • Caltagirone, S.1    Ranelletti, F.O.2    Rinelli, A.3    Maggiano, N.4    Colasante, A.5    Musiani, P.6
  • 15
    • 0031686421 scopus 로고    scopus 로고
    • Sensitivity of human melanoma cells to Oestrogens, tamoxifen and quercetin: Is there any relationship with type i and II oestrogen binding site expression?
    • 1:CAS:528:DyaK1cXmslCgtLY%3D 9764806 10.1097/00008390-199808000-00004
    • Lama G, Angelucci C, Bruzzese N, Nori SL, D'Atri S, Turriziani M, et al. Sensitivity of human melanoma cells to Oestrogens, tamoxifen and quercetin: is there any relationship with type I and II oestrogen binding site expression? Melanoma Res. 1998;8(4):313-22.
    • (1998) Melanoma Res , vol.8 , Issue.4 , pp. 313-322
    • Lama, G.1    Angelucci, C.2    Bruzzese, N.3    Nori, S.L.4    D'Atri, S.5    Turriziani, M.6
  • 17
    • 0023007560 scopus 로고
    • Comparison of bioavailability in man of tamoxifen after oral and rectal administration
    • 1:CAS:528:DyaL2sXitlWrug%3D%3D 2880961 10.1111/j.2042-7158.1986.tb03377.x
    • Tukker JJ, Blankenstein MA, Nortier JW. Comparison of bioavailability in man of tamoxifen after oral and rectal administration. J Pharm Pharmacol. 1986;38(12):888-92.
    • (1986) J Pharm Pharmacol , vol.38 , Issue.12 , pp. 888-892
    • Tukker, J.J.1    Blankenstein, M.A.2    Nortier, J.W.3
  • 18
    • 0028979270 scopus 로고
    • 32P-Postlabelled DNA adducts in liver obtained from women treated with tamoxifen
    • 1:CAS:528:DyaK2MXntVOhur4%3D 7614701 10.1093/carcin/16.7.1651
    • Martin EA, Rich KJ, White INH, Woods KL, Powles TJ, Smith LL. 32P-Postlabelled DNA adducts in liver obtained from women treated with tamoxifen. Carcinogenesis. 1995;16(7):1651-4.
    • (1995) Carcinogenesis , vol.16 , Issue.7 , pp. 1651-1654
    • Martin, E.A.1    Rich, K.J.2    White, I.N.H.3    Woods, K.L.4    Powles, T.J.5    Smith, L.L.6
  • 19
    • 0025310518 scopus 로고
    • Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice: Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant
    • 2353942 10.1016/0006-2952(90)90625-U
    • Lettéron P, Labbe G, Degott C, Berson A, Fromenty B, Delaforge M, et al. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice: evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol. 1990;39(12):2027-34.
    • (1990) Biochem Pharmacol , vol.39 , Issue.12 , pp. 2027-2034
    • Lettéron, P.1    Labbe, G.2    Degott, C.3    Berson, A.4    Fromenty, B.5    Delaforge, M.6
  • 20
    • 0032844037 scopus 로고    scopus 로고
    • The small intestine can both absorb and glucuronidate luminal flavonoids
    • 1:CAS:528:DyaK1MXlvVCgtLs%3D 10481070 10.1016/S0014-5793(99)01160-6
    • Spencer JPE, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458(2):224-30.
    • (1999) FEBS Lett , vol.458 , Issue.2 , pp. 224-230
    • Spencer, J.P.E.1    Chowrimootoo, G.2    Choudhury, R.3    Debnam, E.S.4    Srai, S.K.5    Rice-Evans, C.6
  • 21
    • 84875461286 scopus 로고    scopus 로고
    • Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs
    • 23412102 10.1038/bjc.2013.48
    • van Leeuwen R, Brundel D, Neef C, van Gelder T, Mathijssen R, Burger D, et al. Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs. Br J Cancer. 2013;108(5):1071-8.
    • (2013) Br J Cancer , vol.108 , Issue.5 , pp. 1071-1078
    • Van Leeuwen, R.1    Brundel, D.2    Neef, C.3    Van Gelder, T.4    Mathijssen, R.5    Burger, D.6
  • 22
    • 84878296177 scopus 로고    scopus 로고
    • Oral delivery of anticancer drugs: Challenges and opportunities
    • 1:CAS:528:DC%2BC3sXhtVaktLjP 10.1016/j.jconrel.2013.04.020
    • Thanki K, Gangawal RP, Sangamwar AT, Jain S. Oral delivery of anticancer drugs: challenges and opportunities. J Control Rel. 2013;170(1):15-40.
    • (2013) J Control Rel , vol.170 , Issue.1 , pp. 15-40
    • Thanki, K.1    Gangawal, R.P.2    Sangamwar, A.T.3    Jain, S.4
  • 23
    • 84862830732 scopus 로고    scopus 로고
    • Nanoparticle-based combination therapy toward overcoming drug resistance in cancer
    • 1:CAS:528:DC%2BC38XhvVyiu7c%3D 22285912 10.1016/j.bcp.2012.01.008
    • Hu C-MJ, Zhang L. Nanoparticle-based combination therapy toward overcoming drug resistance in cancer. Biochem Pharmacol. 2012;83(8):1104-11.
    • (2012) Biochem Pharmacol , vol.83 , Issue.8 , pp. 1104-1111
    • Hu, C.-M.1    Zhang, L.2
  • 24
    • 18144419703 scopus 로고    scopus 로고
    • Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention
    • 1:CAS:528:DC%2BD2MXjvVCls7w%3D 10.1016/j.jconrel.2005.01.010
    • Zhigaltsev IV, Maurer N, Akhong Q-F, Leone R, Leng E, Wang J, et al. Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention. J Control Rel. 2005;104(1):103-11.
    • (2005) J Control Rel , vol.104 , Issue.1 , pp. 103-111
    • Zhigaltsev, I.V.1    Maurer, N.2    Akhong, Q.-F.3    Leone, R.4    Leng, E.5    Wang, J.6
  • 25
    • 67650178791 scopus 로고    scopus 로고
    • Pharmacokinetics of CPX-351 (cytarabine/daunorubicin HCl) liposome injection in the mouse
    • 1:CAS:528:DC%2BD1MXmslCgt7k%3D 19009594 10.1002/jps.21620
    • Bayne WF, Mayer LD, Swenson CE. Pharmacokinetics of CPX-351 (cytarabine/daunorubicin HCl) liposome injection in the mouse. J Pharm Sci. 2009;98(7):2540-8.
    • (2009) J Pharm Sci , vol.98 , Issue.7 , pp. 2540-2548
    • Bayne, W.F.1    Mayer, L.D.2    Swenson, C.E.3
  • 26
    • 79958271282 scopus 로고    scopus 로고
    • Coformulation of doxorubicin and curcumin in poly (D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells
    • 1:CAS:528:DC%2BC3MXkslGktLk%3D 10.1021/mp100455h
    • Misra R, Sahoo SK. Coformulation of doxorubicin and curcumin in poly (D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharmaceutics. 2011;8(3):852-66.
    • (2011) Mol Pharmaceutics , vol.8 , Issue.3 , pp. 852-866
    • Misra, R.1    Sahoo, S.K.2
  • 27
    • 79957890122 scopus 로고    scopus 로고
    • Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy
    • 1:CAS:528:DC%2BC3MXmvFyisLY%3D 21600647 10.1016/j.biomaterials.2011.04. 043
    • Acharya S, Sahoo SK. Sustained targeting of Bcr-Abl + leukemia cells by synergistic action of dual drug loaded nanoparticles and its implication for leukemia therapy. Biomaterials. 2011;32(24):5643-62.
    • (2011) Biomaterials , vol.32 , Issue.24 , pp. 5643-5662
    • Acharya, S.1    Sahoo, S.K.2
  • 28
    • 42349106952 scopus 로고    scopus 로고
    • Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer Bioconjugates
    • 1:CAS:528:DC%2BD2sXhtVyksb3J 17600796 10.1002/cmdc.200700121
    • Zhang L, Radovic-Moreno AF, Alexis F, Gu FX, Basto PA, Bagalkot V, et al. Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer Bioconjugates. Chemmedchem. 2007;2(9):1268-71.
    • (2007) Chemmedchem , vol.2 , Issue.9 , pp. 1268-1271
    • Zhang, L.1    Radovic-Moreno, A.F.2    Alexis, F.3    Gu, F.X.4    Basto, P.A.5    Bagalkot, V.6
  • 29
    • 67349283551 scopus 로고    scopus 로고
    • Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles
    • 1:CAS:528:DC%2BD1MXms1Oks7g%3D 19491019 10.1016/j.ejps.2009.02.018
    • Song XR, Cai Z, Zheng Y, He G, Cui FY, Gong DQ, et al. Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles. Eur J Pharm Sci. 2009;37(3):300-5.
    • (2009) Eur J Pharm Sci , vol.37 , Issue.3 , pp. 300-305
    • Song, X.R.1    Cai, Z.2    Zheng, Y.3    He, G.4    Cui, F.Y.5    Gong, D.Q.6
  • 30
    • 67349283045 scopus 로고    scopus 로고
    • Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers
    • 1:CAS:528:DC%2BD1MXlvFGqtLo%3D 19304320 10.1016/j.biomaterials.2009.02. 040
    • Lammers T, Subr V, Ulbrich K, Peschke P, Huber PE, Hennink WE, et al. Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials. 2009;30(20):3466-75.
    • (2009) Biomaterials , vol.30 , Issue.20 , pp. 3466-3475
    • Lammers, T.1    Subr, V.2    Ulbrich, K.3    Peschke, P.4    Huber, P.E.5    Hennink, W.E.6
  • 31
    • 67349247858 scopus 로고    scopus 로고
    • HPMA-based polymer conjugates with drug combination
    • 19491032 10.1016/j.ejps.2009.03.011
    • Krakovičová H, Etrych T, Ulbrich K. HPMA-based polymer conjugates with drug combination. Eur J Pharm Sci. 2009;37(3):405-12.
    • (2009) Eur J Pharm Sci , vol.37 , Issue.3 , pp. 405-412
    • Krakovičová, H.1    Etrych, T.2    Ulbrich, K.3
  • 32
    • 73349141177 scopus 로고    scopus 로고
    • Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells
    • 1:CAS:528:DC%2BD1MXhsFektb3L 2833276 19780069 10.1002/smll.200900621
    • Chen AM, Zhang M, Wei D, Stueber D, Taratula O, Minko T, et al. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells. Small. 2009;5(23):2673-7.
    • (2009) Small , vol.5 , Issue.23 , pp. 2673-2677
    • Chen, A.M.1    Zhang, M.2    Wei, D.3    Stueber, D.4    Taratula, O.5    Minko, T.6
  • 33
    • 68549109372 scopus 로고    scopus 로고
    • Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier
    • 1:CAS:528:DC%2BD1MXpvFCgu7k%3D 19595449 10.1016/j.biomaterials.2009.06. 026
    • Kaneshiro TL, Lu Z-R. Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier. Biomaterials. 2009;30(29):5660-6.
    • (2009) Biomaterials , vol.30 , Issue.29 , pp. 5660-5666
    • Kaneshiro, T.L.1    Lu, Z.-R.2
  • 34
    • 84883581837 scopus 로고    scopus 로고
    • Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: Implications on oral bioavailability, antitumor efficacy and drug induced toxicity
    • 10.1021/mp400311j
    • Jain AK, Thanki K, Jain S. Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy and drug induced toxicity. Mol Pharmaceutics. 2013. doi: 10.1021/mp400311j.
    • (2013) Mol Pharmaceutics
    • Jain, A.K.1    Thanki, K.2    Jain, S.3
  • 35
    • 0343487750 scopus 로고    scopus 로고
    • Formulation of self-emulsifying drug delivery systems
    • 1:CAS:528:DyaK2sXhtlOqsrc%3D 10.1016/S0169-409X(96)00490-5
    • Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev. 1997;25(1):47-58.
    • (1997) Adv Drug Deliv Rev , vol.25 , Issue.1 , pp. 47-58
    • Pouton, C.W.1
  • 36
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • 1:CAS:528:DC%2BD3cXntF2gur4%3D 11033431 10.1016/S0928-0987(00)00167-6
    • Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci. 2000;11:S93-8.
    • (2000) Eur J Pharm Sci , vol.11
    • Pouton, C.W.1
  • 39
    • 84883596511 scopus 로고    scopus 로고
    • Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications on drug induced cardiotoxicity and nephrotoxicity
    • 10.1016/j.freeradbiomed.2013.05.041
    • Jain S, Jain AK, Pohekar M, Thanki K. Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications on drug induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med. 2013;65C:117-30.
    • (2013) Free Radic Biol Med , vol.65 , pp. 117-130
    • Jain, S.1    Jain, A.K.2    Pohekar, M.3    Thanki, K.4
  • 40
    • 45849115831 scopus 로고    scopus 로고
    • Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms
    • 1:CAS:528:DC%2BD1cXotlClsr8%3D 18598917 10.1016/j.drudis.2008.04.006
    • Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today. 2008;13(13):606-12.
    • (2008) Drug Discov Today , vol.13 , Issue.13 , pp. 606-612
    • Tang, B.1    Cheng, G.2    Gu, J.C.3    Xu, C.H.4
  • 41
    • 84858615116 scopus 로고    scopus 로고
    • Oral self emulsifying powder of lercanidipine hydrochloride: Formulation and evaluation
    • 1:CAS:528:DC%2BC38XksVKlsbw%3D 10.1016/j.powtec.2012.01.032
    • Kallakunta VR, Bandari S, Jukanti R, Veerareddy PR. Oral self emulsifying powder of lercanidipine hydrochloride: formulation and evaluation. Powder Technol. 2012;221:375-82.
    • (2012) Powder Technol , vol.221 , pp. 375-382
    • Kallakunta, V.R.1    Bandari, S.2    Jukanti, R.3    Veerareddy, P.R.4
  • 42
    • 84865963565 scopus 로고    scopus 로고
    • Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier
    • 10.1021/mp300298z
    • Van Speybroeck M, Williams HD, Nguyen T-H, Anby MU, Porter CJH, Augustijns P. Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier. Mol Pharmaceutics. 2012;9(9):2750-60.
    • (2012) Mol Pharmaceutics , vol.9 , Issue.9 , pp. 2750-2760
    • Van Speybroeck, M.1    Williams, H.D.2    Nguyen, T.-H.3    Anby, M.U.4    Porter, C.J.H.5    Augustijns, P.6
  • 43
    • 36849049288 scopus 로고    scopus 로고
    • Development of a high throughput equilibrium solubility assay using miniaturized shake flask method in early drug discovery
    • 1:CAS:528:DC%2BD2sXht12jtrrO 17722003 10.1002/jps.20913
    • Zhou L, Yang L, Tilton S, Wang J. Development of a high throughput equilibrium solubility assay using miniaturized shake flask method in early drug discovery. J Pharm Sci. 2007;96(11):3052-71.
    • (2007) J Pharm Sci , vol.96 , Issue.11 , pp. 3052-3071
    • Zhou, L.1    Yang, L.2    Tilton, S.3    Wang, J.4
  • 44
    • 33845576641 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil
    • 1:CAS:528:DC%2BD28XhtlCmtLjN 17010543 10.1016/j.ijpharm.2006.08.038
    • Date AA, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm. 2007;329(1-2):166-72.
    • (2007) Int J Pharm , vol.329 , Issue.1-2 , pp. 166-172
    • Date, A.A.1    Nagarsenker, M.S.2
  • 47
    • 41349096647 scopus 로고    scopus 로고
    • Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    • 1:CAS:528:DC%2BD1cXkt1ygs7k%3D 18242895 10.1016/j.ijpharm.2007.12.026
    • Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm. 2008;355(1):269-76.
    • (2008) Int J Pharm , vol.355 , Issue.1 , pp. 269-276
    • Zhang, P.1    Liu, Y.2    Feng, N.3    Xu, J.4
  • 48
    • 15244353232 scopus 로고    scopus 로고
    • Effect of self-microemulsifying drug delivery systems containing labrasol on tight junctions in caco-2 cells
    • 1:CAS:528:DC%2BD2MXisFGksbc%3D 15784337 10.1016/j.ejps.2005.01.001
    • Sha X, Yan G, Wu Y, Li J, Fang X. Effect of self-microemulsifying drug delivery systems containing labrasol on tight junctions in caco-2 cells. Eur J Pharm Sci. 2005;24(5):477-86.
    • (2005) Eur J Pharm Sci , vol.24 , Issue.5 , pp. 477-486
    • Sha, X.1    Yan, G.2    Wu, Y.3    Li, J.4    Fang, X.5
  • 49
    • 16344385433 scopus 로고    scopus 로고
    • Preparation of nanoparticles composed of chitosan/poly-γ-glutamic acid and evaluation of their permeability through caco-2 cells
    • 1:CAS:528:DC%2BD2MXmslGksA%3D%3D 15762683 10.1021/bm049312a
    • Lin Y-H, Chung C-K, Chen C-T, Liang H-F, Chen S-C, Sung H-W. Preparation of nanoparticles composed of chitosan/poly-γ-glutamic acid and evaluation of their permeability through caco-2 cells. Biomacromolecules. 2005;6(2):1104-12.
    • (2005) Biomacromolecules , vol.6 , Issue.2 , pp. 1104-1112
    • Lin, Y.-H.1    Chung, C.-K.2    Chen, C.-T.3    Liang, H.-F.4    Chen, S.-C.5    Sung, H.-W.6
  • 50
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • 1:CAS:528:DC%2BD2cXjtV2gsLg%3D 15082340 10.1016/j.biopha.2004.02.001
    • Neslihan Gursoy R, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173-82.
    • (2004) Biomed Pharmacother , vol.58 , Issue.3 , pp. 173-182
    • Neslihan Gursoy, R.1    Benita, S.2
  • 51
    • 77951878423 scopus 로고    scopus 로고
    • Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes
    • 1:CAS:528:DC%2BC3cXhsFGqurc%3D 10.1007/s10973-009-0351-6
    • Moyano MA, Broussalis AM, Segall AI. Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes. J Thermal Anal Calorimet. 2010;99(2):631-7.
    • (2010) J Thermal Anal Calorimet , vol.99 , Issue.2 , pp. 631-637
    • Moyano, M.A.1    Broussalis, A.M.2    Segall, A.I.3
  • 52
    • 0035895309 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment
    • 1:CAS:528:DC%2BD3MXmvFKktQ%3D%3D 11165081 10.1016/S0378-5173(00)00614-1
    • Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm. 2001;212(2):233-46.
    • (2001) Int J Pharm , vol.212 , Issue.2 , pp. 233-246
    • Kommuru, T.R.1    Gurley, B.2    Khan, M.A.3    Reddy, I.K.4
  • 53
    • 80054694883 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies
    • 1:CAS:528:DC%2BC3MXhtlWmt77K 21884770 10.1016/j.ijpharm.2011.08.024
    • Li W, Yi S, Wang Z, Chen S, Xin S, Xie J, et al. Self-nanoemulsifying drug delivery system of persimmon leaf extract: optimization and bioavailability studies. Int J Pharm. 2011;420(1):161-71.
    • (2011) Int J Pharm , vol.420 , Issue.1 , pp. 161-171
    • Li, W.1    Yi, S.2    Wang, Z.3    Chen, S.4    Xin, S.5    Xie, J.6
  • 54
    • 0033430984 scopus 로고    scopus 로고
    • Microemulsions: An overview and pharmaceutical applications
    • 1:CAS:528:DC%2BD3cXjs1SjsA%3D%3D 10635455 10.1615/ CritRevTherDrugCarrierSyst.v16.i5.20
    • Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 1999;16(5):461-521.
    • (1999) Crit Rev Ther Drug Carrier Syst , vol.16 , Issue.5 , pp. 461-521
    • Tenjarla, S.1
  • 55
    • 67549133541 scopus 로고    scopus 로고
    • Nanoemulsion components screening and selection: A technical note
    • 1:CAS:528:DC%2BC3cXotV2mtL0%3D 10.1208/s12249-008-9178-x
    • Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Nanoemulsion components screening and selection: a technical note. AAPS Pharm Sci Tech. 2009;10(1):69-76.
    • (2009) AAPS Pharm Sci Tech , vol.10 , Issue.1 , pp. 69-76
    • Azeem, A.1    Rizwan, M.2    Ahmad, F.J.3    Iqbal, Z.4    Khar, R.K.5    Aqil, M.6
  • 56
    • 34247609989 scopus 로고    scopus 로고
    • Development and bioavailability assessment of ramipril nanoemulsion formulation
    • 1:CAS:528:DC%2BD2sXkslCht7w%3D 17127045 10.1016/j.ejpb.2006.10.014
    • Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 2007;66(2):227-43.
    • (2007) Eur J Pharm Biopharm , vol.66 , Issue.2 , pp. 227-243
    • Shafiq, S.1    Shakeel, F.2    Talegaonkar, S.3    Ahmad, F.J.4    Khar, R.K.5    Ali, M.6
  • 58
    • 77957331031 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells
    • 1:CAS:528:DC%2BC3cXht1Ogtr3K 20804812 10.1016/j.fct.2010.08.028
    • Oh SJ, Kim O, Lee JS, Kim J, Kim MR, Choi HS, et al. Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food Chem Toxicol. 2010;48(11):3227-34.
    • (2010) Food Chem Toxicol , vol.48 , Issue.11 , pp. 3227-3234
    • Oh, S.J.1    Kim, O.2    Lee, J.S.3    Kim, J.4    Kim, M.R.5    Choi, H.S.6
  • 59
    • 80054703087 scopus 로고    scopus 로고
    • Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier
    • 1:CAS:528:DC%2BC3MXhtlWmtLrE 21944892 10.1016/j.ijpharm.2011.09.007
    • Oh DH, Kang JH, Kim DW, Lee BJ, Kim JO, Yong CS, et al. Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier. Int J Pharm. 2011;420(2):412-8.
    • (2011) Int J Pharm , vol.420 , Issue.2 , pp. 412-418
    • Oh, D.H.1    Kang, J.H.2    Kim, D.W.3    Lee, B.J.4    Kim, J.O.5    Yong, C.S.6
  • 60
    • 33645294093 scopus 로고    scopus 로고
    • Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
    • 1:CAS:528:DC%2BD28XjtVGqtb8%3D 16516418 10.1016/j.ijpharm.2006.01.028
    • Shin SC, Choi JS, Li X. Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats. Int J Pharm. 2006;313(1):144-9.
    • (2006) Int J Pharm , vol.313 , Issue.1 , pp. 144-149
    • Shin, S.C.1    Choi, J.S.2    Li, X.3
  • 61
    • 0026575081 scopus 로고
    • Trafficking of exogenous fatty acids within caco-2 cells
    • 1:CAS:528:DyaK38XhtVehsrY%3D 1552237
    • Levin MS, Talkad VD, Gordon JI, Stenson WF. Trafficking of exogenous fatty acids within caco-2 cells. J Lipid Res. 1992;33(1):9-19.
    • (1992) J Lipid Res , vol.33 , Issue.1 , pp. 9-19
    • Levin, M.S.1    Talkad, V.D.2    Gordon, J.I.3    Stenson, W.F.4
  • 62
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
    • 1:CAS:528:DC%2BD1cXitVOmsrw%3D 18155316 10.1016/j.addr.2007.09.007
    • Trevaskis NL, Charman WN, Porter CJH. Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv Drug Deliv Rev. 2008;60(6):702-16.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.6 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.