Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro

Molecular and Cellular Endocrinology

Volumn 388, Issue 1-2, 2014, Pages 32-40

  Lammel Lindemann, Jan A ^a,b   Angajala, Anusha ^a   Engler, David A ^a   Webb, Paul ^a,b   Ayers, Stephen D ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

Author keywords

Bile acids; Cholesterol; Cyp7a1; TH; TH receptor

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; LIOTHYRONINE; THYROID HORMONE; THYROID HORMONE RECEPTOR BETA; CYP7A1 PROTEIN, HUMAN; PROTEIN BINDING;

ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; COMPARATIVE STUDY; CONTROLLED STUDY; CYP7A1 GENE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE INDUCTION; HORMONE ACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ADENOVIRIDAE; ANIMAL; ENZYME INDUCTION; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HEPG2 CELL LINE; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION;

ADENOVIRIDAE; ANIMALS; BASE SEQUENCE; CHOLESTEROL 7-ALPHA-HYDROXYLASE; ENZYME INDUCTION; GENE EXPRESSION; HEK293 CELLS; HEP G2 CELLS; HUMANS; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; THYROID HORMONE RECEPTORS BETA; TRIIODOTHYRONINE;

EID: 84897059994     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.02.003     Document Type: Article

References (31)

1. Ayers S., Switnicki M., Angajala A., Lammel J., Webb P. Genome-wide binding patterns of TH receptor beta. PLoS One 2014, 9(2):e81186.
2. Bakker O., Hudig F., Meijssen S., Wiersinga W.M. Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene. Biochem. Biophys. Res. Commun. 1998, 249(2):517-521.
3. Baxter J.D., Webb P. TH mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat. Rev. 2009, 8(4):308-320.
4. Berkenstam A., Kristensen J., Mellstrom K., Carlsson B., Malm J., Rehnmark S., et al. The TH mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc. Natl. Acad. Sci. USA 2008, 105(2):663-667.
5. Chan I.H., Privalsky M.L. Isoform-specific transcriptional activity of overlapping target genes that respond to TH receptors alpha1 and beta1. Mol. Endocrinol. Baltim. Md 2009, 23(11):1758-1775.
6. Drover V.A.B., Agellon L.B. Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by TH in transgenic mice. Endocrinology 2004, 145(2):574-581.
7. Ellis E., Goodwin B., Abrahamsson A., Liddle C., Mode A., Rudling M., et al. Bile acid synthesis in primary cultures of rat and human hepatocytes. Hepatol. Baltim. Md 1998, 27(2):615-620.
8. Gälman C., Arvidsson I., Angelin B., Rudling M. Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. J. Lipid Res. 2003, 44(4):859-866.
9. Gälman C., Bonde Y., Matasconi M., Angelin B., Rudling M. Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by TH. Gastroenterology 2008, 134(4):1127-1136.
10. Goldberg I.J., Huang L.-S., Huggins L.A., Yu S., Nagareddy P.R., Scanlan T.S., et al. TH reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology 2012, 153(11):5143-5149.
11. Gullberg H., Rudling M., Saltó C., Forrest D., Angelin B., Vennström B. Requirement for TH receptor beta in T3 regulation of cholesterol metabolism in mice. Mol. Endocrinol. Baltim. Md 2002, 16(8):1767-1777.
12. Hashimoto K., Cohen R.N., Yamada M., Markan K.R., Monden T., Satoh T., et al. Cross-talk between TH receptor and liver X receptor regulatory pathways is revealed in a TH resistance mouse model. J. Biol. Chem. 2006, 281(1):295-302.
13. Honda A., Yamashita K., Numazawa M., Ikegami T., Doy M., Matsuzaki Y., et al. Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS. J. Lipid Res. 2007, 48(2):458-464.
14. Hylemon P.B., Gurley E.C., Stravitz R.T., Litz J.S., Pandak W.M., Chiang J.Y., et al. Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J. Biol. Chem. 1992, 267(24):16866-16871.
15. Jennen D., Magkoufopoulou C., Ketelslegers H., van Herwijnen M., Kleinjans J., et al. Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol. Sci. Off. J. Soc. Toxicol. 2010, 115(1):66-79.
16. Johansson L., Rudling M., Scanlan T.S., Lundåsen T., Webb P., Baxter J., et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc. Natl. Acad. Sci. USA 2005, 102(29):10297-10302.
17. Kamiya Y., Zhang X.-Y., Ying H., Kato Y., Willingham M.C., Xu J., et al. Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to TH. Endocrinology 2003, 144(9):4144-4153.
18. Ladenson P.W., Kristensen J.D., Ridgway E.C., Olsson A.G., Carlsson B., et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N. Engl. J. Med. 2010, 362(10):906-916.
19. Li T., Matozel M., Boehme S., Kong B., Nilsson L.-M., Guo G., et al. Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatol. Baltim. Md 2011, 53(3):996-1006.
20. Lin J.Z., Martagón A.J., Hsueh W.A., Baxter J.D., Gustafsson J.-Å., Webb P., et al. TH receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology 2012, 153(12):6136-6144.
21. Lin J.Z., Sieglaff D.H., Yuan C., Su J., Arumanayagam A.S., Firouzbakht S., et al. Gene specific actions of TH receptor subtypes. PloS One 2013, 8(1):e52407.
22. Menke J.G., Macnaul K.L., Hayes N.S., Baffic J., Chao Y.-S., Elbrecht A., et al. A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology 2002, 143(7):2548-2558.
23. Meruvu S., Ayers S., Winnier G., Webb P. TH analogues - where do we stand in 2013?. Thyroid Off. J. Am. Thyroid Assoc. 2013.
24. Moore J.T., Goodwin B., Willson T.M., Kliewer S.A. Nuclear receptor regulation of genes involved in bile acid metabolism. Crit. Rev. Eukaryot. Gene Expr. 2002, 12(2):119-135.
25. Ness G.C., Pendelton L.C., Zhao Z. TH rapidly increases cholesterol 7 alpha-hydroxylase mRNA levels in hypophysectomized rats. Biochim. Biophys. Acta 1994, 1214(3):229-233.
26. Ness G.C., Lopez D., Chambers C.M., Newsome W.P., Cornelius P., Long C.A., et al. Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression. Biochem. Pharmacol. 1998, 56(1):121-129.
27. Sauter G., Weiss M., Hoermann R. Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans. Horm. Metab. Res. Horm. Stoffwechselforschung Horm. Métab. 1997, 29(4):176-179.
28. Shin D.-J., Plateroti M., Samarut J., Osborne T.F. Two uniquely arranged TH response elements in the far upstream 5' flanking region confer direct TH regulation to the murine cholesterol 7alpha hydroxylase gene. Nucl. Acids Res. 2006, 34(14):3853-3861.
29. Völzke H., Robinson D.M., John U. Association between thyroid function and gallstone disease. World J. Gastroenterol. WJG 2005, 11(35):5530-5534.
30. Wang D.P., Stroup D., Marrapodi M., Crestani M., Galli G., Chiang J.Y. Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells. J. Lipid Res. 1996, 37(9):1831-1841.
31. Yuan C., Lin J.Z.H., Sieglaff D.H., Ayers S.D., Denoto-Reynolds F., Baxter J.D., et al. Identical gene regulation patterns of T3 and selective TH receptor modulator GC-1. Endocrinology 2012, 153(1):501-511.