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Volumn 29, Issue 4, 2014, Pages 423-431

Melatonin influences pancreatic cancerogenesis

Author keywords

Angiogenesis; Antioxidant enzymes; Apoptosis; Immunomodulation; Melatonin; Pancreatic cancer

Indexed keywords

ANTIOXIDANT; MELATONIN;

EID: 84897032404     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (119)
  • 2
    • 34748924281 scopus 로고    scopus 로고
    • Bcl-2 regulated apoptosis: Mechanism and therapeutic potential
    • Adams J.M. and Cory S. (2007). Bcl-2 regulated apoptosis: mechanism and therapeutic potential. Curr. Opin. Immunol. 19, 488-496.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 488-496
    • Adams, J.M.1    Cory, S.2
  • 3
    • 84876472498 scopus 로고    scopus 로고
    • Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle
    • Ahmed R., Mahavadi S., Al-Shboul O., Bhattacharya S., Grider J.R. and Muthry K.S. (2013). Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle. Regul. Pept. 184, 96-103.
    • (2013) Regul. Pept , vol.184 , pp. 96-103
    • Ahmed, R.1    Mahavadi, S.2    Al-Shboul, O.3    Bhattacharya, S.4    Grider, J.R.5    Muthry, K.S.6
  • 5
    • 70449107007 scopus 로고    scopus 로고
    • Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis
    • Autret A. and Martin S.J. (2009). Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol. Cell. 36, 355-363.
    • (2009) Mol. Cell , vol.36 , pp. 355-363
    • Autret, A.1    Martin, S.J.2
  • 6
    • 0141888993 scopus 로고    scopus 로고
    • Treatment of pancreatic cancer: Challenge of the facts
    • Beger H.G., Rau B., Gansauge F., Poch B. and Link K.H. (2003). Treatment of pancreatic cancer: challenge of the facts. World J. Surg. 27, 1075-1084.
    • (2003) World J. Surg , vol.27 , pp. 1075-1084
    • Beger, H.G.1    Rau, B.2    Gansauge, F.3    Poch, B.4    Link, K.H.5
  • 8
    • 77749277610 scopus 로고    scopus 로고
    • Chemotherapy: Gemcitabine remains the standard of care for pancreatic cancer
    • Berlin J. and Benson A.B. (2010). Chemotherapy: gemcitabine remains the standard of care for pancreatic cancer. Nat. Rev. Clin. Oncol. 7, 135-137.
    • (2010) Nat. Rev. Clin. Oncol , vol.7 , pp. 135-137
    • Berlin, J.1    Benson, A.B.2
  • 9
    • 0022498928 scopus 로고
    • Effects of melatonin on cancer: Studies on MCF-7 human breast cancer cells in culture
    • Blask D.E. and Hill S.M. (1986). Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture. J. Neural Transm. Suppl. 21, 433-449.
    • (1986) J. Neural Transm. Suppl , vol.21 , pp. 433-449
    • Blask, D.E.1    Hill, S.M.2
  • 10
    • 26044479491 scopus 로고    scopus 로고
    • Increase of heat shock protein gene expression by melatonin in AR42J cells
    • Bonior J., Jaworek J., Konturek S.J. and Pawlik W.W. (2005). Increase of heat shock protein gene expression by melatonin in AR42J cells. J. Physiol. Pharmacol. 56, 471-481.
    • (2005) J. Physiol. Pharmacol , vol.56 , pp. 471-481
    • Bonior, J.1    Jaworek, J.2    Konturek, S.J.3    Pawlik, W.W.4
  • 11
    • 51449101022 scopus 로고    scopus 로고
    • Thirty years since the discovery of gastrointestinal melatonin
    • Bubenik G.A. (2008). Thirty years since the discovery of gastrointestinal melatonin. J. Physiol. Pharmacol. 59, 33-51.
    • (2008) J. Physiol. Pharmacol , vol.59 , pp. 33-51
    • Bubenik, G.A.1
  • 12
    • 0030281283 scopus 로고    scopus 로고
    • Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food
    • Bubenik G.A, Pang S.F. and Hacker R.R. (1996). Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food. J. Pineal Res. 21, 251-256.
    • (1996) J. Pineal Res , vol.21 , pp. 251-256
    • Bubenik, G.A.1    Pang, S.F.2    Hacker, R.R.3
  • 14
    • 33646831160 scopus 로고    scopus 로고
    • The modulatory role of melatonin on immune responsiveness
    • Carillo-Vico A. and Reiter R.J. (2006). The modulatory role of melatonin on immune responsiveness. Curr. Opin. Investig. Drugs. 7, 423-431.
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , pp. 423-431
    • Carillo-Vico, A.1    Reiter, R.J.2
  • 15
    • 80054821679 scopus 로고    scopus 로고
    • Distribution, function and physiological role of melatonin in the lower gut
    • Chen C.Q., Fichna J., Bashashati M., Li Y.Y. and Storr M. (2011). Distribution, function and physiological role of melatonin in the lower gut. World J. Gastroenterol. 17, 3888-3898.
    • (2011) World J. Gastroenterol , vol.17 , pp. 3888-3898
    • Chen, C.Q.1    Fichna, J.2    Bashashati, M.3    Li, Y.Y.4    Storr, M.5
  • 18
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos S., Fernández R., Güézmes A. and Sánchez-Barceló E.J. (1998). Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res. 58, 4383-4390.
    • (1998) Cancer Res , vol.58 , pp. 4383-4390
    • Cos, S.1    Fernández, R.2    Güézmes, A.3    Sánchez-Barceló, E.J.4
  • 20
    • 84856706859 scopus 로고    scopus 로고
    • Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression
    • Cui P., Yu M., Peng X., Dong L. and Yang Z. (2012). Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression. J. Pineal Res. 52, 2, 236-243.
    • (2012) J. Pineal Res , vol.52 , Issue.2 , pp. 236-243
    • Cui, P.1    Yu, M.2    Peng, X.3    Dong, L.4    Yang, Z.5
  • 21
    • 44749092510 scopus 로고    scopus 로고
    • Regulatory T cells and treatment of cancer
    • Curiel T.J. (2008). Regulatory T cells and treatment of cancer. Curr. Opin. Immunol. 20, 241-246.
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 241-246
    • Curiel, T.J.1
  • 22
    • 0347601880 scopus 로고    scopus 로고
    • A decade of caspases
    • Degterev A., Boyce M. and Yuan J. (2003). A decade of caspases. Oncogene 22, 8543-8567.
    • (2003) Oncogene , vol.22 , pp. 8543-8567
    • Degterev, A.1    Boyce, M.2    Yuan, J.3
  • 23
    • 77956307408 scopus 로고    scopus 로고
    • Melatonin induces calcium release from CCK-8 and thapsigargin-sensitive cytosolic stores in pancreatic AR42J cells
    • del Castillo-Vaquero A., Salido G.M. and Gonzalez A. (2010). Melatonin induces calcium release from CCK-8 and thapsigargin-sensitive cytosolic stores in pancreatic AR42J cells. J. Pineal Res. 49, 256-263.
    • (2010) J. Pineal Res , vol.49 , pp. 256-263
    • del Castillo-Vaquero, A.1    Salido, G.M.2    Gonzalez, A.3
  • 24
    • 33845988399 scopus 로고    scopus 로고
    • Key aspects of melatonin physiology: Thirty years of research
    • DiBella L. and Gualano L. (2006). Key aspects of melatonin physiology: thirty years of research. Neuro. Endocronol. Lett. 27, 425-432.
    • (2006) Neuro. Endocronol. Lett , vol.27 , pp. 425-432
    • Dibella, L.1    Gualano, L.2
  • 25
    • 84865045103 scopus 로고    scopus 로고
    • VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells
    • Doi Y., Yashiro M., Yamada N., Amano R., Noda S. and Hirakawa K. (2012). VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. Ann. Surg. Oncol. 19, 2733-2743.
    • (2012) Ann. Surg. Oncol , vol.19 , pp. 2733-2743
    • Doi, Y.1    Yashiro, M.2    Yamada, N.3    Amano, R.4    Noda, S.5    Hirakawa, K.6
  • 26
    • 77950485204 scopus 로고    scopus 로고
    • Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats
    • Durante P., Romero F., Perez M. and Parra G. (2010). Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats. Toxicol. Ind. Health 2, 163-174.
    • (2010) Toxicol. Ind. Health , vol.2 , pp. 163-174
    • Durante, P.1    Romero, F.2    Perez, M.3    Parra, G.4
  • 28
    • 58149296552 scopus 로고    scopus 로고
    • Tumor resistance to apoptosis
    • Fulda S. (2009). Tumor resistance to apoptosis. Int. J. Cancer 124, 511-515.
    • (2009) Int. J. Cancer , vol.124 , pp. 511-515
    • Fulda, S.1
  • 30
    • 77955159826 scopus 로고    scopus 로고
    • Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: Role of matrix metalloproteinase-2
    • Ganguly K., Sharma A.V., Reiter R.J. and Swamakar S. (2010).Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metalloproteinase-2. J. Pineal. Res. 49, 130-140.
    • (2010) J. Pineal. Res , vol.49 , pp. 130-140
    • Ganguly, K.1    Sharma, A.V.2    Reiter, R.J.3    Swamakar, S.4
  • 32
    • 33646704720 scopus 로고    scopus 로고
    • Analysis of long-term survivors after surgical resection for pancreatic cancer
    • Han S.S., Jang J.Y., Kim S.W., Kim W.H., Lee K.U. and Park Y.H. (2006). Analysis of long-term survivors after surgical resection for pancreatic cancer. Pancreas 32, 271-275.
    • (2006) Pancreas , vol.32 , pp. 271-275
    • Han, S.S.1    Jang, J.Y.2    Kim, S.W.3    Kim, W.H.4    Lee, K.U.5    Park, Y.H.6
  • 33
    • 46449116418 scopus 로고    scopus 로고
    • Melatonin, hormone of darkness and more: Occurrence, control mechanisms, actions and bioactive metabolites
    • Hardeland R. (2008). Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites. Cell Mol. Life Sci. 65, 2001-2018.
    • (2008) Cell Mol. Life Sci , vol.65 , pp. 2001-2018
    • Hardeland, R.1
  • 34
    • 84866653643 scopus 로고    scopus 로고
    • Melatonin and synthetic melatonergic agonists: Actions and metabolism in the central nervous system
    • Hardeland R. and Poeggeler B. (2012). Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Cent. Nerv. Syst. Agents Med. Chem. 12, 189-216.
    • (2012) Cent. Nerv. Syst. Agents Med. Chem , vol.12 , pp. 189-216
    • Hardeland, R.1    Poeggeler, B.2
  • 35
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland R., Tan D.X. and Reiter RJ. (2009). Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J. Pineal Res. 42, 109-126.
    • (2009) J. Pineal Res , vol.42 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 36
    • 0037208590 scopus 로고    scopus 로고
    • Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: A phase I/II trial
    • Hess V., Salzberg M., Borner M., Morant R., Roth A.D., Ludwig C. and Herrmann R. (2003). Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: a phase I/II trial. J. Clin. Oncol. 1, 66-68.
    • (2003) J. Clin. Oncol , vol.1 , pp. 66-68
    • Hess, V.1    Salzberg, M.2    Borner, M.3    Morant, R.4    Roth, A.D.5    Ludwig, C.6    Herrmann, R.7
  • 39
    • 33749317518 scopus 로고    scopus 로고
    • Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    • Hiraoka N., Onozato K., Kosuge T. and Hirohashi S. (2006). Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin. Cancer. Res. 15, 5423-5434.
    • (2006) Clin. Cancer. Res , vol.15 , pp. 5423-5434
    • Hiraoka, N.1    Onozato, K.2    Kosuge, T.3    Hirohashi, S.4
  • 40
    • 84897047648 scopus 로고    scopus 로고
    • Changes in the immune cell population and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer
    • (in press)
    • Homma Y., Taniguchi K., Nakazawa M., Matsuyama R., Mori R., Takeda K., Ichikawa Y., Tanaka K. and Endo I. (2013). Changes in the immune cell population and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer. Clin. Transl. Oncol. (in press).
    • (2013) Clin. Transl. Oncol
    • Homma, Y.1    Taniguchi, K.2    Nakazawa, M.3    Matsuyama, R.4    Mori, R.5    Takeda, K.6    Ichikawa, Y.7    Tanaka, K.8    Endo, I.9
  • 41
    • 84863768572 scopus 로고    scopus 로고
    • The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma
    • Huang C., Huang R., Chang W., Jiang T., Huang K., Cao J., Sun X. and Qiu Z. (2012). The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Neoplasma 59, 52-61.
    • (2012) Neoplasma , vol.59 , pp. 52-61
    • Huang, C.1    Huang, R.2    Chang, W.3    Jiang, T.4    Huang, K.5    Cao, J.6    Sun, X.7    Qiu, Z.8
  • 42
    • 0031960722 scopus 로고    scopus 로고
    • Effect of continuous melatonin infusions on steady-state plasma melatonin levels in rats under near physiological conditions
    • Huether G., Messner M., Rodenbeck A. and Hardeland R. (1998). Effect of continuous melatonin infusions on steady-state plasma melatonin levels in rats under near physiological conditions. J. Pineal Res. 24, 146-151.
    • (1998) J. Pineal Res , vol.24 , pp. 146-151
    • Huether, G.1    Messner, M.2    Rodenbeck, A.3    Hardeland, R.4
  • 43
    • 33750630223 scopus 로고    scopus 로고
    • Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients
    • Ikemoto T., Yamaguchi T., Morine Y., Imura S., Soejima Y., Fujii M., Maekawa Y., Yasutomo K. and Shimada M. (2006). Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients. Pancreas 33, 386-390.
    • (2006) Pancreas , vol.33 , pp. 386-390
    • Ikemoto, T.1    Yamaguchi, T.2    Morine, Y.3    Imura, S.4    Soejima, Y.5    Fujii, M.6    Maekawa, Y.7    Yasutomo, K.8    Shimada, M.9
  • 44
    • 84875228204 scopus 로고    scopus 로고
    • Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
    • Ino Y., Yamazaki-Itoh R., Shimada K., Iwasaki M., Kosuge T., Kanai Y. and Hiraoka N. (2013). Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br. J. Cancer 108, 914-923.
    • (2013) Br. J. Cancer , vol.108 , pp. 914-923
    • Ino, Y.1    Yamazaki-Itoh, R.2    Shimada, K.3    Iwasaki, M.4    Kosuge, T.5    Kanai, Y.6    Hiraoka, N.7
  • 45
    • 84872490374 scopus 로고    scopus 로고
    • 2-induced apoptosis in gastric and esophageal cancer
    • Izawa S., Mimura K., Watanabe M., Maruyama T., Kawaguchi Y., Fujii H. and Kono K. (2013). Increased prevalence of tumor-infiltrating regulatory T cells is closely related to their lower sensitivity to H2O2-induced apoptosis in gastric and esophageal cancer. Cancer Immunol. Immunother. 62, 161-170.
    • (2013) Cancer Immunol. Immunother , vol.62 , pp. 161-170
    • Izawa, S.1    Mimura, K.2    Watanabe, M.3    Maruyama, T.4    Kawaguchi, Y.5    Fujii, H.6    Kono, K.7
  • 46
    • 12244263456 scopus 로고    scopus 로고
    • Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion
    • Jaworek J., Leja-Szpak A., Bonior J., Nawrot K., Tomaszewska R., Stachura J., Sendur R. and Konturek S.J. (2003). Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion. J. Pineal Res. 34, 40-52.
    • (2003) J. Pineal Res , vol.34 , pp. 40-52
    • Jaworek, J.1    Leja-Szpak, A.2    Bonior, J.3    Nawrot, K.4    Tomaszewska, R.5    Stachura, J.6    Sendur, R.7    Konturek, S.J.8
  • 48
    • 33645733056 scopus 로고    scopus 로고
    • Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells
    • Jiang P.H., Motoo Y., Sawabu N. and Minamoto T. (2006). Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells. World J. Gastroenterol. 12, 1597-1602.
    • (2006) World J. Gastroenterol , vol.12 , pp. 1597-1602
    • Jiang, P.H.1    Motoo, Y.2    Sawabu, N.3    Minamoto, T.4
  • 49
    • 0030843744 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients
    • Kapranos N., Karaiosifidi H., Valavanis C., Kouri E. and Vasilaros S. (1997). Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients. Anticancer Res. 17, 2499-2505.
    • (1997) Anticancer Res , vol.17 , pp. 2499-2505
    • Kapranos, N.1    Karaiosifidi, H.2    Valavanis, C.3    Kouri, E.4    Vasilaros, S.5
  • 50
  • 52
    • 0034320122 scopus 로고    scopus 로고
    • Melatonin and colon carcinogenesis. IV. Effect of melatonin on proliferative activity and expression of apoptosis-related proteins in the spleen of rats exposed to 1,2-dimethylhydrazine
    • Kossoy G., Ben-Hur H., Popovich I., Zabezhinski M., Anisimov V. and Zusman I. (2000). Melatonin and colon carcinogenesis. IV. Effect of melatonin on proliferative activity and expression of apoptosis-related proteins in the spleen of rats exposed to 1,2-dimethylhydrazine. Oncol. Rep. 7, 1401-1405.
    • (2000) Oncol. Rep , vol.7 , pp. 1401-1405
    • Kossoy, G.1    Ben-Hur, H.2    Popovich, I.3    Zabezhinski, M.4    Anisimov, V.5    Zusman, I.6
  • 53
    • 78649389947 scopus 로고    scopus 로고
    • Gastric cancer: Epidemiology and risk factors
    • Krejs G. (2010). Gastric cancer: epidemiology and risk factors. Dig. Dis. 28, 600-603.
    • (2010) Dig. Dis , vol.28 , pp. 600-603
    • Krejs, G.1
  • 54
    • 34447534361 scopus 로고    scopus 로고
    • Melatonin protects from ischemia/reperfusion renal injury in rats: This effect is not mediated by proinflammatory cytokines
    • Kurcer Z., Oguz E., Ozbilge H., Baba F., Aksay N. and Celik N. (2007). Melatonin protects from ischemia/reperfusion renal injury in rats: this effect is not mediated by proinflammatory cytokines. J. Pineal Res. 43, 172-178.
    • (2007) J. Pineal Res , vol.43 , pp. 172-178
    • Kurcer, Z.1    Oguz, E.2    Ozbilge, H.3    Baba, F.4    Aksay, N.5    Celik, N.6
  • 56
    • 0029954952 scopus 로고    scopus 로고
    • Reciprocal expression of Bcl2 and p53 in breast ductal carcinoma
    • Lee W.Y., Jin Y.T. and Tzeng C.C. (1996). Reciprocal expression of Bcl2 and p53 in breast ductal carcinoma. Anticancer Res. 16, 3007-3012.
    • (1996) Anticancer Res , vol.16 , pp. 3007-3012
    • Lee, W.Y.1    Jin, Y.T.2    Tzeng, C.C.3
  • 57
  • 58
    • 77956301403 scopus 로고    scopus 로고
    • Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
    • Leja-Szpak A., Jaworek J., Pierzchalski P. and Reiter R.J. (2010). Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). J. Pineal Res. 49, 3, 248-255.
    • (2010) J. Pineal Res , vol.49 , Issue.3 , pp. 248-255
    • Leja-Szpak, A.1    Jaworek, J.2    Pierzchalski, P.3    Reiter, R.J.4
  • 59
    • 33947460818 scopus 로고
    • Isolation of melatonin, the pineal factor, that lightens melanocytes
    • Lerner A.B., Case J.D., Lee T.H. and Mori W. (1958). Isolation of melatonin, the pineal factor, that lightens melanocytes. J. Am. Chem. Sci. 80, 2587.
    • (1958) J. Am. Chem. Sci , vol.80 , pp. 2587
    • Lerner, A.B.1    Case, J.D.2    Lee, T.H.3    Mori, W.4
  • 60
    • 23844472868 scopus 로고    scopus 로고
    • CD25+ CD4+ regulatory T-cells in cancer
    • Linehan D.C. and Goedegebuure P.S. (2005). CD25+ CD4+ regulatory T-cells in cancer. Immunol. Res. 32, 155-168.
    • (2005) Immunol. Res , vol.32 , pp. 155-168
    • Linehan, D.C.1    Goedegebuure, P.S.2
  • 61
    • 0028811266 scopus 로고
    • Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin a progress report of 200 patients with advanced solid neoplasms
    • Lissoni P., Ardizzoia A., Barni S., Brivio F., Tisi E., Rovelli F., Tancini G., Maestroni G. and Fumagalli L. (1995). Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin a progress report of 200 patients with advanced solid neoplasms. Oncol. Rep. 2, 1063-1068.
    • (1995) Oncol. Rep , vol.2 , pp. 1063-1068
    • Lissoni, P.1    Ardizzoia, A.2    Barni, S.3    Brivio, F.4    Tisi, E.5    Rovelli, F.6    Tancini, G.7    Maestroni, G.8    Fumagalli, L.9
  • 62
    • 0031468676 scopus 로고    scopus 로고
    • Anticancer neuroimmunomodulation by pineal hormones other than melatonin: Preliminary phase II study of the pineal indole 5-methoxytryptophol in association with low-dose IL-2 and melatonin
    • Lissoni P., Fumagalli L., Paolorossi F., Rovelli F., Roselli M.G. and Maestroni G.J. (1997). Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5-methoxytryptophol in association with low-dose IL-2 and melatonin. J. Biol. Regul. Homeost. Agents. 11, 119-22.
    • (1997) J. Biol. Regul. Homeost. Agents , vol.11 , pp. 119-122
    • Lissoni, P.1    Fumagalli, L.2    Paolorossi, F.3    Rovelli, F.4    Roselli, M.G.5    Maestroni, G.J.6
  • 63
    • 42549091038 scopus 로고    scopus 로고
    • Neuroimmunomodulation in medical oncology: Application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors
    • Lissoni P., Brivio F., Fumagalli L., Messina G., Vigoré L., Parolini D., Colciago M. and Rovelli F. (2008). Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors. Anticancer Res. 28, 1377-1381.
    • (2008) Anticancer Res , vol.28 , pp. 1377-1381
    • Lissoni, P.1    Brivio, F.2    Fumagalli, L.3    Messina, G.4    Vigoré, L.5    Parolini, D.6    Colciago, M.7    Rovelli, F.8
  • 64
    • 79954458524 scopus 로고    scopus 로고
    • Role of CD4+ CD25+ regulatory T cells in melatonin-mediated inhibition of murine gastric cancer cell growth in vivo and in vitro
    • Liu H., Xu L., Wei J.E., Xie M.R., Wang S.E. and Zhou R.X. (2011). Role of CD4+ CD25+ regulatory T cells in melatonin-mediated inhibition of murine gastric cancer cell growth in vivo and in vitro. Anat. Rec. (Hoboken). 294, 781-788.
    • (2011) Anat. Rec. (Hoboken) , vol.294 , pp. 781-788
    • Liu, H.1    Xu, L.2    Wei, J.E.3    Xie, M.R.4    Wang, S.E.5    Zhou, R.X.6
  • 65
    • 84995802409 scopus 로고    scopus 로고
    • A comparison of three treatment strategies for locally advanced and borderline resectable pancreatic cancer
    • Lloyd S. and Chang B.W. (2013). A comparison of three treatment strategies for locally advanced and borderline resectable pancreatic cancer. J. Gastrointest. Oncol. 4, 123-130.
    • (2013) J. Gastrointest. Oncol , vol.4 , pp. 123-130
    • Lloyd, S.1    Chang, B.W.2
  • 66
    • 84875442654 scopus 로고    scopus 로고
    • Melatonin inhibits the expression of vascular endothelial growth factor in pancreatic cancer cells
    • Lv D., Cui PL., Yao S.W., Xu Y.Q. and Yang Z.X. (2012). Melatonin inhibits the expression of vascular endothelial growth factor in pancreatic cancer cells. Chin. J. Cancer Res. 24, 310-6.
    • (2012) Chin. J. Cancer Res , vol.24 , pp. 310-316
    • Lv, D.1    Cui, P.L.2    Yao, S.W.3    Xu, Y.Q.4    Yang, Z.X.5
  • 67
    • 0033561382 scopus 로고    scopus 로고
    • Correlation between proliferation, apoptosis, and angiogenesis in prostate carcinoma and their relation to androgen ablation
    • Matsushima H., Goto T., Hosaka Y., Kitamura T. and Kawabe K. (1999). Correlation between proliferation, apoptosis, and angiogenesis in prostate carcinoma and their relation to androgen ablation. Cancer 85, 1822-1827.
    • (1999) Cancer , vol.85 , pp. 1822-1827
    • Matsushima, H.1    Goto, T.2    Hosaka, Y.3    Kitamura, T.4    Kawabe, K.5
  • 69
    • 77954771408 scopus 로고    scopus 로고
    • Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its relation with the psychospiritual status of cancer patients
    • Messina G., Lissoni P., Marchiori P., Bartolacelli E., Brivio F. and Magotti L. (2010). Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its relation with the psychospiritual status of cancer patients. J. Res. Med. Sci. 15, 225-228.
    • (2010) J. Res. Med. Sci , vol.15 , pp. 225-228
    • Messina, G.1    Lissoni, P.2    Marchiori, P.3    Bartolacelli, E.4    Brivio, F.5    Magotti, L.6
  • 70
    • 0035933387 scopus 로고    scopus 로고
    • Presence of melatonin in the human hepatobiliary tract
    • Messner M., Huether G. and Lorf T. (2001). Presence of melatonin in the human hepatobiliary tract. Life Sci. 69, 543-551.
    • (2001) Life Sci , vol.69 , pp. 543-551
    • Messner, M.1    Huether, G.2    Lorf, T.3
  • 71
    • 84885093561 scopus 로고    scopus 로고
    • Role of bacterial infections in pancreatic cancer
    • Michaud D.S. (2013). Role of bacterial infections in pancreatic cancer. Carcinogenesis 34, 2193-2197.
    • (2013) Carcinogenesis , vol.34 , pp. 2193-2197
    • Michaud, D.S.1
  • 73
    • 80053609146 scopus 로고    scopus 로고
    • The effect of whole body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzyme in multiple sclerosis patients
    • Miller E., Mrowicka M., Malinowska K., Kdziora J. and Majsterek I. (2011). The effect of whole body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzyme in multiple sclerosis patients. Pol. Merkur. Lek. 31, 150-153.
    • (2011) Pol. Merkur. Lek , vol.31 , pp. 150-153
    • Miller, E.1    Mrowicka, M.2    Malinowska, K.3    Kdziora, J.4    Majsterek, I.5
  • 75
    • 77956924838 scopus 로고    scopus 로고
    • Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer
    • Muilenburg D.J., Coates J.M., Virudachalam S. and Bold R.J. (2010). Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer. J. Surg. Res. 163, 276-281.
    • (2010) J. Surg. Res , vol.163 , pp. 276-281
    • Muilenburg, D.J.1    Coates, J.M.2    Virudachalam, S.3    Bold, R.J.4
  • 79
    • 80054822424 scopus 로고    scopus 로고
    • Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males
    • Ochoa J.J., Diaz-Castro J., Kajarabille N., Garcia N., Guisado I.M., De Teresa C. and Guisado R. (2011). Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J. Pineal Res. 51, 373-380.
    • (2011) J. Pineal Res , vol.51 , pp. 373-380
    • Ochoa, J.J.1    Diaz-Castro, J.2    Kajarabille, N.3    Garcia, N.4    Guisado, I.M.5    de Teresa, C.6    Guisado, R.7
  • 80
    • 58149331193 scopus 로고    scopus 로고
    • Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737
    • Okumura K., Huang S. and Sinicrope F.A. (2008). Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. Clin. Cancer Res. 14, 8132-8142.
    • (2008) Clin. Cancer Res , vol.14 , pp. 8132-8142
    • Okumura, K.1    Huang, S.2    Sinicrope, F.A.3
  • 84
    • 35348847902 scopus 로고    scopus 로고
    • Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats
    • Paredes S.D., Sanchez S., Parvez H., Rodriquez A.B. and Barriga C. (2007). Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats. Neuro. Endocrinol. Lett. 11, 489-495.
    • (2007) Neuro. Endocrinol. Lett , vol.11 , pp. 489-495
    • Paredes, S.D.1    Sanchez, S.2    Parvez, H.3    Rodriquez, A.B.4    Barriga, C.5
  • 87
    • 0016808318 scopus 로고
    • Melatonin may be synthetized in enterochromaffine cells
    • Raikhlin N.T., Kvetnoy I.M. and Tolkahev V.N. (1975). Melatonin may be synthetized in enterochromaffine cells. Nature 255, 344-350.
    • (1975) Nature , vol.255 , pp. 344-350
    • Raikhlin, N.T.1    Kvetnoy, I.M.2    Tolkahev, V.N.3
  • 91
    • 84864550431 scopus 로고    scopus 로고
    • Reactive oxygen species, inflammation, and lung disease
    • Rosanna D.P. and Salvadore C. (2012). Reactive oxygen species, inflammation, and lung disease. Curr. Pharm. Des. 18, 3889-3900.
    • (2012) Curr. Pharm. Des , vol.18 , pp. 3889-3900
    • Rosanna, D.P.1    Salvadore, C.2
  • 94
    • 35748929435 scopus 로고    scopus 로고
    • Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: Up-regulation of thymidine phosphorylase
    • Saif M.W., Black G., Roy S., Bell D., Russo S., Eloubeidi M.A., Steg A., Johnson M.R., Zelterman D. and Diasio R.B. (2007). Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylase. Cancer J. 13, 247-256.
    • (2007) Cancer J , vol.13 , pp. 247-256
    • Saif, M.W.1    Black, G.2    Roy, S.3    Bell, D.4    Russo, S.5    Eloubeidi, M.A.6    Steg, A.7    Johnson, M.R.8    Zelterman, D.9    Diasio, R.B.10
  • 95
    • 80054874386 scopus 로고    scopus 로고
    • Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats
    • Shagirtha K., Muthumani M. and Prabu S.M. (2011). Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats. Eur. Rev. Med. Pharmacol. Sci. 15, 1039-1050.
    • (2011) Eur. Rev. Med. Pharmacol. Sci , vol.15 , pp. 1039-1050
    • Shagirtha, K.1    Muthumani, M.2    Prabu, S.M.3
  • 96
    • 23844450083 scopus 로고    scopus 로고
    • Potential role of oxygen species in pancreatitis-associated multiple organ dysfunction
    • Shi C., Andersson R., Zhao X. and Wang X. (2005). Potential role of oxygen species in pancreatitis-associated multiple organ dysfunction. Pancreatology 5, 492-500.
    • (2005) Pancreatology , vol.5 , pp. 492-500
    • Shi, C.1    Andersson, R.2    Zhao, X.3    Wang, X.4
  • 97
    • 84864708909 scopus 로고    scopus 로고
    • Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes
    • Shigematsu Y., Hanagiri T., Shiota H., Kuroda K., Baba T., Ichiki Y., Yasuda M., Uramoto H., Takenoyama M., Yasumoto K. and Tanaka F. (2012). Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes. Oncol. Lett. 4, 625-630.
    • (2012) Oncol. Lett , vol.4 , pp. 625-630
    • Shigematsu, Y.1    Hanagiri, T.2    Shiota, H.3    Kuroda, K.4    Baba, T.5    Ichiki, Y.6    Yasuda, M.7    Uramoto, H.8    Takenoyama, M.9    Yasumoto, K.10    Tanaka, F.11
  • 100
    • 73749085277 scopus 로고    scopus 로고
    • Immunohistochemical definition of MT(2) receptors and melatonin in the gastrointestinal tissues of rat
    • Stebelova, K., Anttila K., Manttari S., Saarela S.I. and Zeman M. (2010). Immunohistochemical definition of MT(2) receptors and melatonin in the gastrointestinal tissues of rat. Acta Histochem. 112, 26-33.
    • (2010) Acta Histochem , vol.112 , pp. 26-33
    • Stebelova, K.1    Anttila, K.2    Manttari, S.3    Saarela, S.I.4    Zeman, M.5
  • 104
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with the reactive oxygen and nitrogen species
    • Tan D.X., Manchester L.C., Terran M.P., Flores L.J. and Reiter R.J. (2007). One molecule, many derivatives: a never-ending interaction of melatonin with the reactive oxygen and nitrogen species. J. Pineal. Res. 42, 28-42.
    • (2007) J. Pineal. Res , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terran, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 105
    • 84855584391 scopus 로고    scopus 로고
    • The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide
    • Tan G., Zhang X., Feng H., Luo H. and Wang Z. (2011). The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with K-ras mutant peptide. Clin. Dev. Immunol. 649359.
    • (2011) Clin. Dev. Immunol , pp. 649359
    • Tan, G.1    Zhang, X.2    Feng, H.3    Luo, H.4    Wang, Z.5
  • 107
    • 84873458408 scopus 로고    scopus 로고
    • Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eucaryotes
    • Tan D.X., Manchester L.C., Liu X., Rosales-Corral S.A., Acuna-Castroviejo D. and Reiter R. (2013). Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eucaryotes. J. Pineal Res. 54, 127-138.
    • (2013) J. Pineal Res , vol.54 , pp. 127-138
    • Tan, D.X.1    Manchester, L.C.2    Liu, X.3    Rosales-Corral, S.A.4    Acuna-Castroviejo, D.5    Reiter, R.6
  • 108
    • 70349203687 scopus 로고    scopus 로고
    • Effect of melatonin and L-tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria)
    • Terron M.P., Delgado J., Paredes S.D., Barriga C., Reiter R.J. and Rodroguez A.B. (2009). Effect of melatonin and L-tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Exp. Gerontol. 44, 653-658.
    • (2009) Exp. Gerontol , vol.44 , pp. 653-658
    • Terron, M.P.1    Delgado, J.2    Paredes, S.D.3    Barriga, C.4    Reiter, R.J.5    Rodroguez, A.B.6
  • 109
    • 84863595623 scopus 로고    scopus 로고
    • Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells
    • Uguz A.C., Cig B., Espino J., Bejarano I., Naziroglu M., Rodríguez A.B. and Pariente J.A. (2012). Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells. J. Pineal Res. 53, 1, 91-98.
    • (2012) J. Pineal Res , vol.53 , Issue.1 , pp. 91-98
    • Uguz, A.C.1    Cig, B.2    Espino, J.3    Bejarano, I.4    Naziroglu, M.5    Rodríguez, A.B.6    Pariente, J.A.7
  • 110
    • 78649251119 scopus 로고    scopus 로고
    • Psychoneuroendocrine modulation of regulatory T lymphocyte system: In vivo and in vitro effects of the pineal immunomodulating hormone melatonin
    • Vigoré L., Messina G., Brivio F., Fumagalli L., Rovelli F., DI Fede G. and Lissoni P. (2010). Psychoneuroendocrine modulation of regulatory T lymphocyte system: in vivo and in vitro effects of the pineal immunomodulating hormone melatonin. In Vivo 24, 787-789.
    • (2010) In Vivo , vol.24 , pp. 787-789
    • Vigoré, L.1    Messina, G.2    Brivio, F.3    Fumagalli, L.4    Rovelli, F.5    Di Fede, G.6    Lissoni, P.7
  • 112
    • 0036092840 scopus 로고    scopus 로고
    • Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
    • Xu Z.W., Friess H., Büchler M.W. and Solioz M. (2002). Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. Cancer Chemother. Pharmacol. 49, 504-510.
    • (2002) Cancer Chemother. Pharmacol , vol.49 , pp. 504-510
    • Xu, Z.W.1    Friess, H.2    Büchler, M.W.3    Solioz, M.4
  • 113
    • 84875381309 scopus 로고    scopus 로고
    • Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance
    • Xu C., Wu A., Zhu H., Fang H., Xu L., Ye J. and Shen J. (2013). Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance. Biomed. Pharmacother. 67, 133-139.
    • (2013) Biomed. Pharmacother , vol.67 , pp. 133-139
    • Xu, C.1    Wu, A.2    Zhu, H.3    Fang, H.4    Xu, L.5    Ye, J.6    Shen, J.7
  • 115
    • 79954622997 scopus 로고    scopus 로고
    • Melatonin ameliorates hemorrhagic shock-induced organ damage in rats
    • Yang F.L., Soberg M.Y., Lee C.J., Lee RP., Peng T.C. and Hsu B.G. (2011). Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. J. Surg. Res. 167,15-21.
    • (2011) J. Surg. Res , vol.167 , pp. 15-21
    • Yang, F.L.1    Soberg, M.Y.2    Lee, C.J.3    Lee, R.P.4    Peng, T.C.5    Hsu, B.G.6
  • 117
    • 67651151194 scopus 로고    scopus 로고
    • Physiology and pharmacology of melatonin in relation to biological rhythms
    • Zawilska J.B., Skene D.J. and Arendt J. (2009). Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol. Rep. 61, 383-410.
    • (2009) Pharmacol. Rep , vol.61 , pp. 383-410
    • Zawilska, J.B.1    Skene, D.J.2    Arendt, J.3
  • 118
    • 68249113734 scopus 로고    scopus 로고
    • Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma
    • Zhao F., Obermann S., von Wasielewski R., Haile L., Manns M.P., Korangy F. and Greten TF. (2009). Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. Immunology 128, 1141-149.
    • (2009) Immunology , vol.128 , pp. 1141-1149
    • Zhao, F.1    Obermann, S.2    von Wasielewski, R.3    Haile, L.4    Manns, M.P.5    Korangy, F.6    Greten, T.F.7
  • 119
    • 73349105927 scopus 로고    scopus 로고
    • Effect of melatonin on proliferation of neonatal cord blond mononuclear cells
    • Zhou W., Wang P. and Tao L. (2009). Effect of melatonin on proliferation of neonatal cord blond mononuclear cells. World J. Pediatr. 5, 300-303.
    • (2009) World J. Pediatr , vol.5 , pp. 300-303
    • Zhou, W.1    Wang, P.2    Tao, L.3


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