Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle

Regulatory Peptides

Volumn 184, Issue , 2013, Pages 96-103

  Ahmed, Rashad ^a   Mahavadi, Sunila ^a   Al Shboul, Othman ^a   Bhattacharya, Sayak ^a   Grider, John R ^a   Murthy, Karnam S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Contraction; G protein; Signal transduction; Smooth muscle

Indexed keywords

CALCIUM ION; FURA 2; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PROTEIN GQ; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; DISPERSION; ENZYME ACTIVITY; LIPID HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; STOMACH MUSCLE;

ANIMALS; GASTROINTESTINAL TRACT; ISOINDOLES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RABBITS; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; SIGNAL TRANSDUCTION;

ORYCTOLAGUS CUNICULUS;

EID: 84876472498     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2013.03.028     Document Type: Article

References (40)

1. Zawilska J.B., Skene D.J., Arendt J. Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep 2009, 61:383-410.
2. Raikhlin N.T., Kvetnoy I.M. Melatonin and enterochromaffine cells. Acta Histochem 1976, 55:19-24.
3. Raikhlin N.T., Kvetnoy I.M., Tolkachev V.N. Melatonin may be synthesised in enterochromaffin cells. Nature 1975, 255:344-345.
4. Kvetnoy I.M., Ingel I.E., Kvetnaia T.V., Malinovskaya N.K., Rapoport S.I., Raikhlin N.T., Trofimov A.V., Yuzhakov V.V. Gastrointestinal melatonin: cellular identification and biological role. Neuro Endocrinol Lett 2002, 23:121-132.
5. Bubenik G.A., Hacker R.R., Brown G.M., Bartos L. Melatonin concentrations in the luminal fluid, mucosa, and muscularis of the bovine and porcine gastrointestinal tract. J Pineal Res 1999, 26:56-63.
6. Lee P.P., Pang S.F. Melatonin and its receptors in the gastrointestinal tract. Biol Signals 1993, 2:181-193.
7. Chen C.Q., Fichna J., Bashashati M., Li Y.Y., Storr M. Distribution, function and physiological role of melatonin in the lower gut. World J Gastroenterol 2007, 17:3888-3898.
8. Thor P.J., Krolczyk G., Gil K., Zurowski D., Nowak L. Melatonin and serotonin effects on gastrointestinal motility. J Physiol Pharmacol 2007, 58(Suppl. 6):97-103.
9. Teresa Martin M., Azpiroz F., Malagelada J.R. Melatonin as a modulator of the ileal brake mechanism. Scand J Gastroenterol 2005, 40:559-563.
10. Martin M.T., Azpiroz F., Malagelada J.R. Melatonin and the gastrointestinal tract. Therapie 1998, 53:453-458.
11. Reppert S.M. Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J Biol Rhythms 1997, 12:528-531.
12. Reppert S.M., Godson C., Mahle C.D., Weaver D.R., Slaugenhaupt S.A., Gusella J.F. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci USA 1995, 92:8734-8738.
13. Reppert S.M., Weaver D.R., Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994, 13:1177-1185.
14. 2 melatonin receptors in mammals. Endocrine 2005, 27:101-110.
15. von Gall C., Stehle J.H., Weaver D.R. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res 2002, 309:151-162.
16. Drago F., Macauda S., Salehi S. Small doses of melatonin increase intestinal motility in rats. Dig Dis Sci 2002, 47:1969-1974.
17. Kasimay O., Cakir B., Devseren E., Yegen B.C. Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors. J Physiol Pharmacol 2005, 56:543-553.
18. Storr M., Schusdziarra V., Allescher H.D. Inhibition of small conductance K+-channels attenuated melatonin-induced relaxation of serotonin-contracted rat gastric fundus. Can J Physiol Pharmacol 2000, 78:799-806.
19. Storr M., Koppitz P., Sibaev A., Saur D., Kurjak M., Franck H., Schusdziarra V., Allescher H.D. Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro. J Pineal Res 2002, 33:101-108.
20. Merle A., Delagrange P., Renard P., Lesieur D., Cuber J.C., Roche M., Pellissier S. Effect of melatonin on motility pattern of small intestine in rats and its inhibition by melatonin receptor antagonist S 22153. J Pineal Res 2000, 29:116-124.
21. Lucchelli A., Santagostino-Barbone M.G., Tonini M. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol 1997, 121:1775-1781.
22. 3 in circular muscle cells. Am J Physiol 1991, 261:G945-G951.
23. Murthy K.S., Makhlouf G.M. Functional characterization of phosphoinositide-specific phospholipase C-beta1 and beta 3 in intestinal smooth muscle. Am J Physiol 1995, 269:C969-C978.
24. Teng B., Murthy K.S., Kuemmerle J.F., Grider J.R., Sase K., Michel T., Makhlouf G.M. Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells. Am J Physiol 1998, 275:G342-G351.
25. Gilchrist A., Li A., Hamm H.E. Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. Methods Enzymol 2002, 344:58-69.
26. Gilchrist A., Vanhauwe J.F., Li A., Thomas T.O., Voyno-Yasenetskaya T., Hamm H.E. G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J Biol Chem 2001, 276:25672-25679.
27. Gilchrist A., Bunemann M., Li A., Hosey M.M., Hamm H.E. A dominant-negative strategy for studying roles of G proteins in vivo. J Biol Chem 1999, 274:6610-6616.
28. Zhou H., Murthy K.S. Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. Am J Physiol Cell Physiol 2004, 286:C1130-C1138.
29. Sriwai W., Zhou H., Murthy K.S. G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA. Biochem J 2008, 411:543-551.
30. Huang J., Zhou H., Mahavadi S., Sriwai W., Lyall V., Murthy K.S. Signaling pathways mediated gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol 2005, 288:G23-G31.
31. Ting K.N., Blaylock N.A., Sugden D., Delagrange P., Scalbert E., Wilson V.G. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol 1999, 127:987-995.
32. 2 melatonin receptor agonist in the rat. Neurosci Lett 2009, 457:93-96.
33. Dortch-Carnes J., Tosini G. Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells. Exp Eye Res 2012, 107:1-10.
34. Murthy K.S. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol 2006, 68:345-374.
35. Murthy K.S., Makhlouf G.M. Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle:dual requirement for alpha and beta gamma subunits of Gi3. Mol Pharmacol 1995, 47:1172-1179.
36. Dubocovich M.L., Delagrange P., Krause D.N., Sugden D., Cardinali D.P., Olcese J. International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev 2010, 62:343-380.
37. Lee P.P., Shiu S.Y., Chow P.H., Pang S.F. Regional and diurnal studies of melatonin and melatonin binding sites in the duck gastro-intestinal tract. Biol Signals 1995, 4:212-224.
38. Stebelova K., Anttila K., Manttari S., Saarela S., Zeman M. Immunohistochemical definition of MT(2) receptors and melatonin in the gastrointestinal tissues of rat. Acta Histochem 2010, 112:26-33.
39. Poon A.M., Mak A.S., Luk H.T. Melatonin and 2[125I]iodomelatonin binding sites in the human colon. Endocr Res 1996, 22:77-94.
40. Pontoire C., Bernard M., Silvain C., Collin J.P., Voisin P. Characterization of melatonin binding sites in chicken and human intestines. Eur J Pharmacol 1993, 247:111-118.