메뉴 건너뛰기




Volumn 163, Issue 2, 2010, Pages 276-281

Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer

Author keywords

apoptosis; autophagy; Bcl 2; beclin 1; BH 3; pancreatic cancer

Indexed keywords

A 779024; ANTINEOPLASTIC AGENT; BECLIN 1; GREEN FLUORESCENT PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; RAPAMYCIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN (53-86); BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; PEPTIDE FRAGMENT;

EID: 77956924838     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.02.021     Document Type: Article
Times cited : (8)

References (32)
  • 1
    • 0037530398 scopus 로고    scopus 로고
    • Expression of the Bcl-2 gene and its significance in human pancreatic carcinoma
    • C.Y. Sun, B.L. Wang, and C.Q. Hu Expression of the Bcl-2 gene and its significance in human pancreatic carcinoma Hepatobiliary Pancreat Dis Int 1 2002 306
    • (2002) Hepatobiliary Pancreat Dis Int , vol.1 , pp. 306
    • Sun, C.Y.1    Wang, B.L.2    Hu, C.Q.3
  • 3
    • 21244474683 scopus 로고    scopus 로고
    • Targeting Bcl-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib
    • B.N. Fahy, M.G. Schlieman, and M.M. Mortenson Targeting Bcl-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib Cancer Chemother Pharmacol 56 2005 46
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 46
    • Fahy, B.N.1    Schlieman, M.G.2    Mortenson, M.M.3
  • 4
    • 36849063240 scopus 로고    scopus 로고
    • Bcl-2 functions as an activator of the AKT signaling pathway in pancreatic cancer
    • M.M. Mortenson, J.G. Galante, and O. Gilad Bcl-2 functions as an activator of the AKT signaling pathway in pancreatic cancer J Cell Biochem 102 2007 1171
    • (2007) J Cell Biochem , vol.102 , pp. 1171
    • Mortenson, M.M.1    Galante, J.G.2    Gilad, O.3
  • 5
    • 0033122710 scopus 로고    scopus 로고
    • Prognostic factors in resectable pancreatic cancer: P53 and Bcl-2
    • R.J. Bold, K.R. Hess, and A.S. Pearson Prognostic factors in resectable pancreatic cancer: p53 and Bcl-2 J Gastrointest Surg 3 1999 263
    • (1999) J Gastrointest Surg , vol.3 , pp. 263
    • Bold, R.J.1    Hess, K.R.2    Pearson, A.S.3
  • 6
    • 68249106060 scopus 로고    scopus 로고
    • BH3-only proteins in apoptosis and beyond: An overview
    • E. Lomonosova, and G. Chinnadurai BH3-only proteins in apoptosis and beyond: An overview Oncogene 27 Suppl 1 2008 S2
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1 , pp. 2
    • Lomonosova, E.1    Chinnadurai, G.2
  • 7
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector beclin 1: A novel BH3-only protein
    • S. Sinha, and B. Levine The autophagy effector beclin 1: A novel BH3-only protein Oncogene 27 Suppl 1 2008 S137
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1 , pp. 137
    • Sinha, S.1    Levine, B.2
  • 8
    • 26044462215 scopus 로고    scopus 로고
    • Targeting Bcl-2 protein expression in solid tumors and hematologic malignancies with antisense oligonucleotides
    • A.W. Tolcher Targeting Bcl-2 protein expression in solid tumors and hematologic malignancies with antisense oligonucleotides Clin Adv Hematol Oncol 3 2005 635
    • (2005) Clin Adv Hematol Oncol , vol.3 , pp. 635
    • Tolcher, A.W.1
  • 9
    • 67650648494 scopus 로고    scopus 로고
    • Small-molecule BH3 mimetics to antagonize Bcl-2-homolog survival functions in cancer
    • K.C. Goldsmith, and M.D. Hogarty Small-molecule BH3 mimetics to antagonize Bcl-2-homolog survival functions in cancer Curr Opin Investig Drugs 10 2009 559
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 559
    • Goldsmith, K.C.1    Hogarty, M.D.2
  • 10
    • 48249087666 scopus 로고    scopus 로고
    • Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
    • U. Akar, A. Chaves-Reyez, and M. Barria Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells Autophagy 4 2008 669
    • (2008) Autophagy , vol.4 , pp. 669
    • Akar, U.1    Chaves-Reyez, A.2    Barria, M.3
  • 11
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: Autophagy and cancer
    • B. Levine Cell biology: Autophagy and cancer Nature 446 Apr 12 2007 745
    • (2007) Nature , vol.446 , pp. 745
    • Levine, B.1
  • 13
    • 57849136841 scopus 로고    scopus 로고
    • Autophagy: Principles and significance in health and disease
    • V. Todde, M. Veenhuis, and I.J. van der Klei Autophagy: Principles and significance in health and disease Biochim Biophys Acta 1792 2009 3
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 3
    • Todde, V.1    Veenhuis, M.2    Van Der Klei, I.J.3
  • 14
    • 27644514227 scopus 로고    scopus 로고
    • Another way to die: Autophagic programmed cell death
    • Y. Tsujimoto, and S. Shimizu Another way to die: Autophagic programmed cell death Cell Death Differ 12 Suppl 2 2005 1528
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1528
    • Tsujimoto, Y.1    Shimizu, S.2
  • 15
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • D. Gozuacik, and A. Kimchi Autophagy as a cell death and tumor suppressor mechanism Oncogene 23 2004 2891
    • (2004) Oncogene , vol.23 , pp. 2891
    • Gozuacik, D.1    Kimchi, A.2
  • 16
    • 0034509103 scopus 로고    scopus 로고
    • Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?
    • W. Bursch, A. Ellinger, and C. Gerner Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann N Y Acad Sci 926 2000 1
    • (2000) Ann N y Acad Sci , vol.926 , pp. 1
    • Bursch, W.1    Ellinger, A.2    Gerner, C.3
  • 17
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • D.J. Klionsky, and S.D. Emr Autophagy as a regulated pathway of cellular degradation Science 290 2000 1717
    • (2000) Science , vol.290 , pp. 1717
    • Klionsky, D.J.1    Emr, S.D.2
  • 18
    • 34447571032 scopus 로고    scopus 로고
    • The correct way to monitor autophagy in higher eukaryotes
    • D.J. Klionsky The correct way to monitor autophagy in higher eukaryotes Autophagy 1 2005 65
    • (2005) Autophagy , vol.1 , pp. 65
    • Klionsky, D.J.1
  • 19
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • N. Furuya, J. Yu, M. Byfield, S. Pattingre, and B. Levine The evolutionarily conserved domain of beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function Autophagy 1 2005 46
    • (2005) Autophagy , vol.1 , pp. 46
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 20
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Y. Kabeya, N. Mizushima, and T. Ueno LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720
    • (2000) EMBO J , vol.19 , pp. 5720
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 21
    • 4344604111 scopus 로고    scopus 로고
    • HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
    • I. Tanida, Y.S. Sou, and J. Ezaki HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates J Biol Chem 279 2004 36268
    • (2004) J Biol Chem , vol.279 , pp. 36268
    • Tanida, I.1    Sou, Y.S.2    Ezaki, J.3
  • 22
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy
    • S. Pattingre, A. Tassa, and X. Qu Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy Cell 122 2005 927
    • (2005) Cell , vol.122 , pp. 927
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 23
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • B. Levine, and D.J. Klionsky Development by self-digestion: Molecular mechanisms and biological functions of autophagy Dev Cell 6 2004 463
    • (2004) Dev Cell , vol.6 , pp. 463
    • Levine, B.1    Klionsky, D.J.2
  • 24
    • 67650270918 scopus 로고    scopus 로고
    • Phosphorylation of beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
    • E. Zalckvar, H. Berissi, and M. Eisenstein Phosphorylation of beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL Autophagy 5 2009 720
    • (2009) Autophagy , vol.5 , pp. 720
    • Zalckvar, E.1    Berissi, H.2    Eisenstein, M.3
  • 25
    • 75149167546 scopus 로고    scopus 로고
    • Beclin 1 modulates the anti-apoptotic activity of Bcl-2: Insights from a pathogen infection system
    • C.L. Vazquez, and M.I. Colombo beclin 1 modulates the anti-apoptotic activity of Bcl-2: Insights from a pathogen infection system Autophagy 6 2010 177
    • (2010) Autophagy , vol.6 , pp. 177
    • Vazquez, C.L.1    Colombo, M.I.2
  • 26
    • 69449089542 scopus 로고    scopus 로고
    • Why doesn't beclin 1, a BH3-only protein, suppress the anti-apoptotic function of Bcl-2?
    • I.A. Ciechomska, C.G. Goemans, and A.M. Tolkovsky Why doesn't beclin 1, a BH3-only protein, suppress the anti-apoptotic function of Bcl-2? Autophagy 5 2009 880
    • (2009) Autophagy , vol.5 , pp. 880
    • Ciechomska, I.A.1    Goemans, C.G.2    Tolkovsky, A.M.3
  • 27
    • 63149129655 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
    • M.H. Kang, and C.P. Reynolds Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy Clin Cancer Res 15 2009 1126
    • (2009) Clin Cancer Res , vol.15 , pp. 1126
    • Kang, M.H.1    Reynolds, C.P.2
  • 28
    • 68149112387 scopus 로고    scopus 로고
    • Mimicking the BH3 domain to kill cancer cells
    • T.N. Chonghaile, and A. Letai Mimicking the BH3 domain to kill cancer cells Oncogene 27 Suppl 1 2008 S149
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1 , pp. 149
    • Chonghaile, T.N.1    Letai, A.2
  • 29
    • 77956893785 scopus 로고    scopus 로고
    • BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists
    • K.C. Goldsmith, B.J. Lestini, and M. Gross BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists Cell Death Differ 2009 epub ahead of print. PMID19893570
    • (2009) Cell Death Differ
    • Goldsmith, K.C.1    Lestini, B.J.2    Gross, M.3
  • 30
    • 34547603628 scopus 로고    scopus 로고
    • BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
    • J. Deng, N. Carlson, and K. Takeyama BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents Cancer Cell 12 2007 171
    • (2007) Cancer Cell , vol.12 , pp. 171
    • Deng, J.1    Carlson, N.2    Takeyama, K.3
  • 32
    • 77956919073 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • PMID 20034776
    • Z. Yang, and D.J. Klionsky Mammalian autophagy: Core molecular machinery and signaling regulation Curr Opin Cell Biol 2009 epub ahead of print. PMID 20034776
    • (2009) Curr Opin Cell Biol
    • Yang, Z.1    Klionsky, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.