FK506 protects against articular cartilage collagenous extra-cellular matrix degradation

Osteoarthritis and Cartilage

Volumn 22, Issue 4, 2014, Pages 591-600

  Siebelt, M ^a   Van der Windt, A E ^a   Groen, H C ^a   Sandker, M ^a   Waarsing, J H ^a   Muller C ^b   De Jong, M ^a   Jahr, H ^a,c   Weinans, H ^d,e  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ETH Zurich   (Switzerland)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Activation of synovial macrophages; Cartilage matrix degradation; FK506; Osteoarthritis; Osteoclastic subchondral bone resorption

Indexed keywords

PAPAIN; TACROLIMUS; CALCINEURIN INHIBITOR; CONTRAST MEDIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOSYNTHESIS; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CATABOLISM; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; EX VIVO STUDY; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KNEE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; NONHUMAN; OSTEOPHYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TRABECULAR BONE; ANIMAL; CASE CONTROL STUDY; DIAGNOSTIC USE; DISEASE MODEL; DRUG EFFECTS; HINDLIMB; MICRO-COMPUTED TOMOGRAPHY; OSTEOARTHRITIS, KNEE; PATHOLOGY; PROCEDURES; RADIOGRAPHY; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; CALCINEURIN INHIBITORS; CARTILAGE, ARTICULAR; CASE-CONTROL STUDIES; CHONDROCYTES; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; HUMANS; MACROPHAGES; MALE; OSTEOARTHRITIS, KNEE; RATS; RATS, WISTAR; STIFLE; TACROLIMUS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME; X-RAY MICROTOMOGRAPHY;

EID: 84897020903     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.02.003     Document Type: Article

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