메뉴 건너뛰기




Volumn 9, Issue , 2014, Pages 103-118

The pathogenesis of chronic lymphocytic leukemia

Author keywords

B cell signaling; Cell origin; Genetic alterations; Microenvironment

Indexed keywords

B LYMPHOCYTE; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; DISEASE COURSE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; PATHOLOGY; REVIEW; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 84897018638     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-020712-163955     Document Type: Article
Times cited : (96)

References (120)
  • 3
    • 0026038974 scopus 로고
    • B-cell chronic lymphocytic leukemia: Present status and future directions. French Cooperative Group on CLL
    • Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet JL. 1991. B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL. Blood 78:1901-14
    • (1991) Blood , vol.78 , pp. 1901-1914
    • Dighiero, G.1    Travade, P.2    Chevret, S.3    Fenaux, P.4    Chastang, C.5    Binet, J.L.6
  • 4
    • 79958008875 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: The pathologists view of lymph node microenvironment
    • Ponzoni M, Doglioni C, Caligaris-Cappio F. 2011. Chronic lymphocytic leukemia: the pathologists view of lymph node microenvironment. Semin. Diagn. Pathol. 28:161-66
    • (2011) Semin. Diagn. Pathol. , vol.28 , pp. 161-166
    • Ponzoni, M.1    Doglioni, C.2    Caligaris-Cappio, F.3
  • 5
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. 2009. The microenvironment in mature B cell malignancies: a target for new treatment strategies. Blood 114:3367-75
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 6
    • 0023869947 scopus 로고
    • Immunoarchitecture of the "pseudofollicles" of well-differentiated (small) lymphocytic lymphoma: A comparison with true follicles
    • Ratech H, Sheibani K, Nathwani BN, Rappaport H. 1988. Immunoarchitecture of the "pseudofollicles" of well-differentiated (small) lymphocytic lymphoma: a comparison with true follicles. Hum. Pathol. 19:89-94
    • (1988) Hum. Pathol. , vol.19 , pp. 89-94
    • Ratech, H.1    Sheibani, K.2    Nathwani, B.N.3    Rappaport, H.4
  • 7
    • 0028335475 scopus 로고
    • Proliferation centres in B cell malignant lymphoma, lymphocytic (B-CLL): An immunophenotypic study
    • Schmid C, Isaacson PG. 1994. Proliferation centres in B cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study. Histopathology 24:445-51
    • (1994) Histopathology , vol.24 , pp. 445-451
    • Schmid, C.1    Isaacson, P.G.2
  • 8
    • 30744467923 scopus 로고    scopus 로고
    • The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Soma LA, Craig FE, Swerdlow SH. 2006. The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma. Hum. Pathol. 37:152-59
    • (2006) Hum. Pathol. , vol.37 , pp. 152-159
    • Soma, L.A.1    Craig, F.E.2    Swerdlow, S.H.3
  • 9
    • 79955835038 scopus 로고    scopus 로고
    • Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles
    • Vandewoestyne ML, Pede VC, Lambein KY, Dhaenens MF, Offner FC, et al. 2011. Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles. Leukemia 25:883-88
    • (2011) Leukemia , vol.25 , pp. 883-888
    • Vandewoestyne, M.L.1    Pede, V.C.2    Lambein, K.Y.3    Dhaenens, M.F.4    Offner, F.C.5
  • 10
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    • Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, et al. 2005. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J. Clin. Investig. 115:755-64
    • (2005) J. Clin. Investig. , vol.115 , pp. 755-764
    • Messmer, B.T.1    Messmer, D.2    Allen, S.L.3    Kolitz, J.E.4    Kudalkar, P.5
  • 13
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, et al. 1999. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840-47
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3    Ghiotto, F.4    Valetto, A.5
  • 14
    • 0033304511 scopus 로고    scopus 로고
    • Hormones and heart disease in women: Heart and Estrogen/Progestin Replacement Study in perspective
    • Barrett-Connor E, Stuenkel C. 1999. Hormones and heart disease in women: Heart and Estrogen/Progestin Replacement Study in perspective. J. Clin. Endocrinol. Metab. 84:1848-53
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 1848-1853
    • Barrett-Connor, E.1    Stuenkel, C.2
  • 15
    • 0020054334 scopus 로고
    • Infrequent normal B lymphocytes express features of B chronic lymphocytic leukemia
    • Caligaris-Cappio F, Gobbi M, Bofill M, Janossy G. 1982. Infrequent normal B lymphocytes express features of B chronic lymphocytic leukemia. J. Exp. Med. 155:623-28
    • (1982) J. Exp. Med. , vol.155 , pp. 623-628
    • Caligaris-Cappio, F.1    Gobbi, M.2    Bofill, M.3    Janossy, G.4
  • 16
    • 0029990349 scopus 로고    scopus 로고
    • B chronic lymphocytic leukemia: A malignancy of anti-self B cells
    • Caligaris-Cappio F. 1996. B chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 87:2615-20
    • (1996) Blood , vol.87 , pp. 2615-2620
    • Caligaris-Cappio, F.1
  • 17
    • 34547903876 scopus 로고    scopus 로고
    • CD5+ B cells with the features of subepithelial B cells found in human tonsils
    • Dono M, Burgio VL, Colombo M, Sciacchitano S, Reverberi D, et al. 2007. CD5+ B cells with the features of subepithelial B cells found in human tonsils. Eur. J. Immunol. 37:2138-47
    • (2007) Eur. J. Immunol. , vol.37 , pp. 2138-2147
    • Dono, M.1    Burgio, V.L.2    Colombo, M.3    Sciacchitano, S.4    Reverberi, D.5
  • 18
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
    • Chiorazzi N, Ferrarini M. 2011. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 117:1781-91
    • (2011) Blood , vol.117 , pp. 1781-1791
    • Chiorazzi, N.1    Ferrarini, M.2
  • 19
    • 74949107027 scopus 로고    scopus 로고
    • The normal IGHV1-69-derived B cell repertoire contains stereotypic patterns characteristic of unmutated CLL
    • Forconi F, Potter KN, Wheatley I, Darzentas N, Sozzi E, et al. 2010. The normal IGHV1-69-derived B cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood 115:71-77
    • (2010) Blood , vol.115 , pp. 71-77
    • Forconi, F.1    Potter, K.N.2    Wheatley, I.3    Darzentas, N.4    Sozzi, E.5
  • 20
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, et al. 2001. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J. Exp. Med. 194:1625-38
    • (2001) J. Exp. Med. , vol.194 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3    Mattioli, M.4    Cattoretti, G.5
  • 21
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, et al. 2001. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194:1639-47
    • (2001) J. Exp. Med. , vol.194 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3    Simon, R.4    Davis, R.E.5
  • 22
    • 19344376101 scopus 로고    scopus 로고
    • Identification and characterization of circulating human transitional B cells
    • Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. 2005. Identification and characterization of circulating human transitional B cells. Blood 105:4390-98
    • (2005) Blood , vol.105 , pp. 4390-4398
    • Sims, G.P.1    Ettinger, R.2    Shirota, Y.3    Yarboro, C.H.4    Illei, G.G.5    Lipsky, P.E.6
  • 23
    • 57149094311 scopus 로고    scopus 로고
    • Characterization of phenotypically distinct B cell subsets and receptor-stimulated mitogen-Activated protein kinase activation in human cord blood B cells
    • Ha YJ, Mun YC, Seong CM, Lee JR. 2008. Characterization of phenotypically distinct B cell subsets and receptor-stimulated mitogen-Activated protein kinase activation in human cord blood B cells. J. Leukoc. Biol. 84:1557-64
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 1557-1564
    • Ha, Y.J.1    Mun, Y.C.2    Seong, C.M.3    Lee, J.R.4
  • 24
    • 40849145800 scopus 로고    scopus 로고
    • Transitional B cells in humans: Characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation
    • Marie-Cardine A, Divay F, Dutot I, Green A, Perdrix A, et al. 2008. Transitional B cells in humans: characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation. Clin. Immunol. 127:14-25
    • (2008) Clin. Immunol. , vol.127 , pp. 14-25
    • Marie-Cardine, A.1    Divay, F.2    Dutot, I.3    Green, A.4    Perdrix, A.5
  • 26
    • 0036785288 scopus 로고    scopus 로고
    • Inherited predisposition to CLL is detectable as subclinical monoclonal B lymphocyte expansion
    • Rawstron AC, Yuille MR, Fuller J, Cullen M, Kennedy B, et al. 2002. Inherited predisposition to CLL is detectable as subclinical monoclonal B lymphocyte expansion. Blood 100:2289-90
    • (2002) Blood , vol.100 , pp. 2289-2290
    • Rawstron, A.C.1    Yuille, M.R.2    Fuller, J.3    Cullen, M.4    Kennedy, B.5
  • 27
    • 0037100421 scopus 로고    scopus 로고
    • Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts
    • Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JA, et al. 2002. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 100:635-39
    • (2002) Blood , vol.100 , pp. 635-639
    • Rawstron, A.C.1    Green, M.J.2    Kuzmicki, A.3    Kennedy, B.4    Fenton, J.A.5
  • 28
    • 1542283720 scopus 로고    scopus 로고
    • Monoclonal CD5+ and CD5- B lymphocyte expansions are frequent in the peripheral blood of the elderly
    • Ghia P, Prato G, Scielzo C, Stella S, GeunaM, et al. 2004. Monoclonal CD5+ and CD5- B lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 103:2337-42
    • (2004) Blood , vol.103 , pp. 2337-2342
    • Ghia, P.1    Prato, G.2    Scielzo, C.3    Stella, S.4    Geuna, M.5
  • 30
    • 33750531056 scopus 로고    scopus 로고
    • Follicular lymphoma-like B cells in healthy individuals: A novel intermediate step in early lymphomagenesis
    • Roulland S, Navarro JM, Grenot P, Milili M, Agopian J, et al. 2006. Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J. Exp. Med. 203:2425-31
    • (2006) J. Exp. Med. , vol.203 , pp. 2425-2431
    • Roulland, S.1    Navarro, J.M.2    Grenot, P.3    Milili, M.4    Agopian, J.5
  • 31
    • 38949156617 scopus 로고    scopus 로고
    • Unique cell surface expression of receptor tyrosine kinaseROR1 in human B cell chronic lymphocytic leukemia
    • Baskar S, Kwong KY, Hofer T, Levy JM, Kennedy MG, et al. 2008. Unique cell surface expression of receptor tyrosine kinaseROR1 in human B cell chronic lymphocytic leukemia. Clin. Cancer Res. 14:396-404
    • (2008) Clin. Cancer Res. , vol.14 , pp. 396-404
    • Baskar, S.1    Kwong, K.Y.2    Hofer, T.3    Levy, J.M.4    Kennedy, M.G.5
  • 32
    • 47249140824 scopus 로고    scopus 로고
    • ROR1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy
    • Daneshmanesh AH, Mikaelsson E, Jeddi-Tehrani M, Bayat AA, Ghods R, et al. 2008. ROR1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. Int. J. Cancer 123:1190-95
    • (2008) Int. J. Cancer , vol.123 , pp. 1190-1195
    • Daneshmanesh, A.H.1    Mikaelsson, E.2    Jeddi-Tehrani, M.3    Bayat, A.A.4    Ghods, R.5
  • 33
    • 42949121156 scopus 로고    scopus 로고
    • Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
    • Fukuda T, Chen L, Endo T, Tang L, Lu D, et al. 2008. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl. Acad. Sci. USA 105:3047-52
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3047-3052
    • Fukuda, T.1    Chen, L.2    Endo, T.3    Tang, L.4    Lu, D.5
  • 34
    • 84863251015 scopus 로고    scopus 로고
    • ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth
    • Zhang S, Chen L, Cui B, Chuang HY, Yu J, et al. 2012. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS ONE 7:e31127
    • (2012) PLoS ONE , vol.7 , pp. e31127
    • Zhang, S.1    Chen, L.2    Cui, B.3    Chuang, H.Y.4    Yu, J.5
  • 35
    • 84869166013 scopus 로고    scopus 로고
    • The onco-embryonic antigen ROR1 is expressed by a variety of human cancers
    • Zhang S, Chen L, Wang-Rodriguez J, Zhang L, Cui B, et al. 2012. The onco-embryonic antigen ROR1 is expressed by a variety of human cancers. Am. J. Pathol. 181:1903-10
    • (2012) Am. J. Pathol. , vol.181 , pp. 1903-1910
    • Zhang, S.1    Chen, L.2    Wang-Rodriguez, J.3    Zhang, L.4    Cui, B.5
  • 36
    • 80052079318 scopus 로고    scopus 로고
    • ROR1 is expressed on hematogones (non-neoplastic human B lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia
    • Broome HE, Rassenti LZ, Wang HY, Meyer LM, Kipps TJ. 2011. ROR1 is expressed on hematogones (non-neoplastic human B lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia. Leuk. Res. 35:1390-94
    • (2011) Leuk. Res. , vol.35 , pp. 1390-1394
    • Broome, H.E.1    Rassenti, L.Z.2    Wang, H.Y.3    Meyer, L.M.4    Kipps, T.J.5
  • 39
    • 80051589767 scopus 로고    scopus 로고
    • Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia
    • Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, et al. 2011. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell 20:246-59
    • (2011) Cancer Cell , vol.20 , pp. 246-259
    • Kikushige, Y.1    Ishikawa, F.2    Miyamoto, T.3    Shima, T.4    Urata, S.5
  • 40
    • 9144245353 scopus 로고    scopus 로고
    • Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin v gene mutations
    • Damle RN, Batliwalla FM, Ghiotto F, Valetto A, Albesiano E, et al. 2004. Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. Blood 103:375-82
    • (2004) Blood , vol.103 , pp. 375-382
    • Damle, R.N.1    Batliwalla, F.M.2    Ghiotto, F.3    Valetto, A.4    Albesiano, E.5
  • 41
    • 32944468017 scopus 로고    scopus 로고
    • The evolution of adaptive immune systems
    • Cooper MD, Alder MN. 2006. The evolution of adaptive immune systems. Cell 124:815-22
    • (2006) Cell , vol.124 , pp. 815-822
    • Cooper, M.D.1    Alder, M.N.2
  • 42
    • 42449120194 scopus 로고    scopus 로고
    • Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3
    • Widhopf GF 2nd, Goldberg CJ, Toy TL, Rassenti LZ, Wierda WG, et al. 2008. Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. Blood 111:3137-44
    • (2008) Blood , vol.111 , pp. 3137-3144
    • Widhopf, I.I.G.F.1    Goldberg, C.J.2    Toy, T.L.3    Rassenti, L.Z.4    Wierda, W.G.5
  • 43
    • 0027717083 scopus 로고
    • Immunoglobulin genes in chronic lymphocytic leukemia
    • discussion 631-32
    • Kipps TJ. 1993. Immunoglobulin genes in chronic lymphocytic leukemia. Blood Cells 19:615-25; discussion 631-32
    • (1993) Blood Cells , vol.19 , pp. 615-625
    • Kipps, T.J.1
  • 44
    • 0042971643 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor
    • Chiorazzi N, Ferrarini M. 2003. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu. Rev. Immunol. 21:841-94
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 841-894
    • Chiorazzi, N.1    Ferrarini, M.2
  • 45
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Revelations from the B cell receptor
    • Stevenson FK, Caligaris-Cappio F. 2004. Chronic lymphocytic leukemia: revelations from the B cell receptor. Blood 103:4389-95
    • (2004) Blood , vol.103 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 46
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, et al. 1998. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Investig. 102:1515-25
    • (1998) J. Clin. Investig. , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3    Sellars, B.4    Valetto, A.5
  • 47
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Myhrinder AL, Hellqvist E, Sidorova E, Soderberg A, Baxendale H, et al. 2008. A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 111:3838-48
    • (2008) Blood , vol.111 , pp. 3838-3848
    • Myhrinder, A.L.1    Hellqvist, E.2    Sidorova, E.3    Soderberg, A.4    Baxendale, H.5
  • 48
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, et al. 2008. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol. Med. 14:665-74
    • (2008) Mol. Med. , vol.14 , pp. 665-674
    • Catera, R.1    Silverman, G.J.2    Hatzi, K.3    Seiler, T.4    Didier, S.5
  • 49
    • 55749091407 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    • Chu CC, Catera R, HatziK, Yan XJ, Zhang L, et al. 2008. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 112:5122-29
    • (2008) Blood , vol.112 , pp. 5122-5129
    • Chu, C.C.1    Catera, R.2    Hatzi, K.3    Yan, X.J.4    Zhang, L.5
  • 50
    • 70449506033 scopus 로고    scopus 로고
    • Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
    • Seiler T, Woelfle M, Yancopoulos S, Catera R, Li W, et al. 2009. Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells. Blood 114:3615-24
    • (2009) Blood , vol.114 , pp. 3615-3624
    • Seiler, T.1    Woelfle, M.2    Yancopoulos, S.3    Catera, R.4    Li, W.5
  • 51
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: Implications for patient outcome and cell of origin
    • Chu CC, Catera R, Zhang L, Didier S, Agagnina BM, et al. 2010. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood 115:3907-15
    • (2010) Blood , vol.115 , pp. 3907-3915
    • Chu, C.C.1    Catera, R.2    Zhang, L.3    Didier, S.4    Agagnina, B.M.5
  • 52
    • 77956370064 scopus 로고    scopus 로고
    • Antigens in CLL: Themes and variations
    • Stamatopoulos K. 2010. Antigens in CLL: themes and variations. Blood 115:3855-56
    • (2010) Blood , vol.115 , pp. 3855-3856
    • Stamatopoulos, K.1
  • 53
    • 33847373538 scopus 로고    scopus 로고
    • Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    • Landgren O, Rapkin JS, Caporaso NE, Mellemkjaer L, Gridley G, et al. 2007. Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. Blood 109:2198-201
    • (2007) Blood , vol.109 , pp. 2198-2201
    • Landgren, O.1    Rapkin, J.S.2    Caporaso, N.E.3    Mellemkjaer, L.4    Gridley, G.5
  • 54
    • 67349164793 scopus 로고    scopus 로고
    • Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B cell receptors
    • Kostareli E, Hadzidimitriou A, Stavroyianni N, Darzentas N, Athanasiadou A, et al. 2009. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B cell receptors. Leukemia 23:919-24
    • (2009) Leukemia , vol.23 , pp. 919-924
    • Kostareli, E.1    Hadzidimitriou, A.2    Stavroyianni, N.3    Darzentas, N.4    Athanasiadou, A.5
  • 55
    • 65549143196 scopus 로고    scopus 로고
    • Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia
    • Steininger C, Rassenti LZ, Vanura K, Eigenberger K, Jager U, et al. 2009. Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia. Eur. J. Clin. Investig. 39:497-506
    • (2009) Eur. J. Clin. Investig. , vol.39 , pp. 497-506
    • Steininger, C.1    Rassenti, L.Z.2    Vanura, K.3    Eigenberger, K.4    Jager, U.5
  • 56
    • 84858019141 scopus 로고    scopus 로고
    • Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B cell superantigen
    • Steininger C, Widhopf GF 2nd, Ghia EM, Morello CS, Vanura K, et al. 2012. Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B cell superantigen. Blood 119:2293-301
    • (2012) Blood , vol.119 , pp. 2293-2301
    • Steininger, C.1    Widhopf, I.I.G.F.2    Ghia, E.M.3    Morello, C.S.4    Vanura, K.5
  • 57
    • 84860748545 scopus 로고    scopus 로고
    • Antigen receptor stereotypy across B cell lymphoproliferations: The case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity
    • Kostareli E, GounariM, Janus A, Murray F, Brochet X, et al. 2012. Antigen receptor stereotypy across B cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. Leukemia 26:1127-31
    • (2012) Leukemia , vol.26 , pp. 1127-1131
    • Kostareli, E.1    Gounari, M.2    Janus, A.3    Murray, F.4    Brochet, X.5
  • 58
    • 84867154468 scopus 로고    scopus 로고
    • Molecular pathogenesis of chronic lymphocytic leukemia
    • Gaidano G, Foa R, Dalla-Favera R. 2012. Molecular pathogenesis of chronic lymphocytic leukemia. J. Clin. Investig. 122:3432-38
    • (2012) J. Clin. Investig. , vol.122 , pp. 3432-3438
    • Gaidano, G.1    Foa, R.2    Dalla-Favera, R.3
  • 61
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, et al. 2011. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J. Exp. Med. 208:1389-401
    • (2011) J. Exp. Med. , vol.208 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3    Trifonov, V.4    Khiabanian, H.5
  • 62
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, et al. 2011. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101-5
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3    Conde, L.4    Ordonez, G.R.5
  • 63
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, Conde L, Villamor N, Ordonez GR, Jares P, et al. 2012. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat. Genet. 44:47-52
    • (2012) Nat. Genet. , vol.44 , pp. 47-52
    • Quesada, V.1    Conde, L.2    Villamor, N.3    Ordonez, G.R.4    Jares, P.5
  • 64
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, et al. 2011. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N. Engl. J. Med. 365:2497-506
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2497-2506
    • Wang, L.1    Lawrence, M.S.2    Wan, Y.3    Stojanov, P.4    Sougnez, C.5
  • 65
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine refractoriness
    • Rossi D, Bruscaggin A, Spina V, Rasi S, Khiabanian H, et al. 2011. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine refractoriness. Blood 118:6904-8
    • (2011) Blood , vol.118 , pp. 6904-6908
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3    Rasi, S.4    Khiabanian, H.5
  • 66
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, et al. 2012. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119:521-29
    • (2012) Blood , vol.119 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3    Spina, V.4    Fangazio, M.5
  • 67
    • 84858859064 scopus 로고    scopus 로고
    • Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    • Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, et al. 2012. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 119:2854-62
    • (2012) Blood , vol.119 , pp. 2854-2862
    • Rossi, D.1    Fangazio, M.2    Rasi, S.3    Vaisitti, T.4    Monti, S.5
  • 68
    • 79959549536 scopus 로고    scopus 로고
    • T cell lineage commitment: Identity and renunciation
    • Rothenberg EV. 2011. T cell lineage commitment: identity and renunciation. J. Immunol. 186:6649-55
    • (2011) J. Immunol. , vol.186 , pp. 6649-6655
    • Rothenberg, E.V.1
  • 69
    • 34848842174 scopus 로고    scopus 로고
    • Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells
    • Santos MA, Sarmento LM, Rebelo M, Doce AA, Maillard I, et al. 2007. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc. Natl. Acad. Sci. USA 104:15454-59
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 15454-15459
    • Santos, M.A.1    Sarmento, L.M.2    Rebelo, M.3    Doce, A.A.4    Maillard, I.5
  • 72
    • 84857739865 scopus 로고    scopus 로고
    • NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
    • Del Giudice I, Rossi D, Chiaretti S, Marinelli M, Tavolaro S, et al. 2012. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica 97:437-41
    • (2012) Haematologica , vol.97 , pp. 437-441
    • Del Giudice, I.1    Rossi, D.2    Chiaretti, S.3    Marinelli, M.4    Tavolaro, S.5
  • 73
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R. 2009. The spliceosome: design principles of a dynamic RNP machine. Cell 136:701-18
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 74
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, et al. 2013. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152:714-26
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3    McKenna, A.4    Stevenson, K.5
  • 75
    • 84877608629 scopus 로고    scopus 로고
    • Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia
    • Schwaederle M, Ghia E, Rassenti LZ, Obara M, DellAquila ML, et al. 2013. Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia. Leukemia 27:1214-17
    • (2013) Leukemia , vol.27 , pp. 1214-1217
    • Schwaederle, M.1    Ghia, E.2    Rassenti, L.Z.3    Obara, M.4    Dellaquila, M.L.5
  • 76
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. 2009. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 77
    • 33846258010 scopus 로고    scopus 로고
    • BAFF and APRIL support chronic lymphocytic leukemia B cell survival through activation of the canonical NF-κB pathway
    • Endo T, Nishio M, EnzlerT, CottamHB, Fukuda T, et al. 2007. BAFF and APRIL support chronic lymphocytic leukemia B cell survival through activation of the canonical NF-κB pathway. Blood 109:703-10
    • (2007) Blood , vol.109 , pp. 703-710
    • Endo, T.1    Nishio, M.2    Enzler, T.3    Cottam, H.B.4    Fukuda, T.5
  • 78
    • 73349098730 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
    • Enzler T, Kater AP, Zhang W, Widhopf GF 2nd, Chuang HY, et al. 2009. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood 114:4469-76
    • (2009) Blood , vol.114 , pp. 4469-4476
    • Enzler, T.1    Kater, A.P.2    Zhang, W.3    Widhopf, I.I.G.F.4    Chuang, H.Y.5
  • 79
    • 78650481186 scopus 로고    scopus 로고
    • B cell activating factor and v-Mycmyelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia
    • ZhangW, Kater AP, Widhopf GF 2nd, Chuang HY, Enzler T, et al. 2010. B cell activating factor and v-Mycmyelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 107:18956-60
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 18956-18960
    • Zhang, W.1    Kater, A.P.2    Widhopf, I.I.G.F.3    Chuang, H.Y.4    Enzler, T.5
  • 80
    • 58149355768 scopus 로고    scopus 로고
    • The novel nuclear factor κb inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine
    • Hewamana S, Lin TT, Jenkins C, Burnett AK, Jordan CT, et al. 2008. The novel nuclear factor κB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine. Clin. Cancer Res. 14:8102-11
    • (2008) Clin. Cancer Res. , vol.14 , pp. 8102-8111
    • Hewamana, S.1    Lin, T.T.2    Jenkins, C.3    Burnett, A.K.4    Jordan, C.T.5
  • 81
    • 77955870224 scopus 로고    scopus 로고
    • 17-DMAG targets the nuclear factor κb family of proteins to induce apoptosis in chronic lymphocytic leukemia: Clinical implications of HSP90 inhibition
    • Hertlein E, Wagner AJ, Jones J, Lin TS, Maddocks KJ, et al. 2010. 17-DMAG targets the nuclear factor κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood 116:45-53
    • (2010) Blood , vol.116 , pp. 45-53
    • Hertlein, E.1    Wagner, A.J.2    Jones, J.3    Lin, T.S.4    Maddocks, K.J.5
  • 82
    • 84865475885 scopus 로고    scopus 로고
    • MYD88 L265P somatic mutation in Waldenstroms macroglobulinemia
    • Treon SP, Xu L, Yang G, Zhou, Y, Liu X, et al. 2012. MYD88 L265P somatic mutation in Waldenstroms macroglobulinemia. N. Engl. J. Med. 367:826-33
    • (2012) N. Engl. J. Med. , vol.367 , pp. 826-833
    • Treon, S.P.1    Xu, L.2    Yang, G.3    Zhou, Y.4    Liu, X.5
  • 83
    • 17044406054 scopus 로고    scopus 로고
    • CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival
    • Deaglio S, Vaisitti T, Bergui L, Bonello L, Horenstein AL, et al. 2005. CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival. Blood 105:3042-50
    • (2005) Blood , vol.105 , pp. 3042-3050
    • Deaglio, S.1    Vaisitti, T.2    Bergui, L.3    Bonello, L.4    Horenstein, A.L.5
  • 85
    • 79551686422 scopus 로고    scopus 로고
    • Oncogenically active MYD88 mutations in human lymphoma
    • Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, et al. 2011. Oncogenically active MYD88 mutations in human lymphoma. Nature 470:115-19
    • (2011) Nature , vol.470 , pp. 115-119
    • Ngo, V.N.1    Young, R.M.2    Schmitz, R.3    Jhavar, S.4    Xiao, W.5
  • 86
    • 77958164865 scopus 로고    scopus 로고
    • LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B cell lymphocytosis
    • Gutierrez A Jr, Tschumper RC, Wu X, Shanafelt TD, Eckel-Passow J, et al. 2010. LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B cell lymphocytosis. Blood 116:2975-83
    • (2010) Blood , vol.116 , pp. 2975-2983
    • Gutierrez, A.1    Tschumper, R.C.2    Wu, X.3    Shanafelt, T.D.4    Eckel-Passow, J.5
  • 87
    • 1542267803 scopus 로고    scopus 로고
    • Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
    • Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, et al. 2004. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 101:3118-23
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3118-3123
    • Lu, D.1    Zhao, Y.2    Tawatao, R.3    Cottam, H.B.4    Sen, M.5
  • 88
    • 77954069621 scopus 로고    scopus 로고
    • Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of theWnt/β-catenin pathway
    • Lu D, Liu JX, Endo T, Zhou H, Yao S, et al. 2009. Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of theWnt/β-catenin pathway. PLoS ONE 4:e8294
    • (2009) PLoS ONE , vol.4 , pp. e8294
    • Lu, D.1    Liu, J.X.2    Endo, T.3    Zhou, H.4    Yao, S.5
  • 89
    • 80052012674 scopus 로고    scopus 로고
    • Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
    • Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA. 2011. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc.Natl. Acad. Sci. USA108:13253-57
    • (2011) Proc.Natl. Acad. Sci. USA , vol.108 , pp. 13253-13257
    • Lu, D.1    Choi, M.Y.2    Yu, J.3    Castro, J.E.4    Kipps, T.J.5    Carson, D.A.6
  • 90
    • 84869805516 scopus 로고    scopus 로고
    • CLL clonal heterogeneity: An ecology of competing subpopulations
    • Wu CJ. 2012. CLL clonal heterogeneity: an ecology of competing subpopulations. Blood 120:4117-18
    • (2012) Blood , vol.120 , pp. 4117-4118
    • Wu, C.J.1
  • 91
    • 84869753284 scopus 로고    scopus 로고
    • Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns
    • Schuh A, Becq J, Humphray S, Alexa A, Burns A, et al. 2012. Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood 120:4191-96
    • (2012) Blood , vol.120 , pp. 4191-4196
    • Schuh, A.1    Becq, J.2    Humphray, S.3    Alexa, A.4    Burns, A.5
  • 92
    • 84865176364 scopus 로고    scopus 로고
    • The B cell receptor signaling pathway as a therapeutic target in CLL
    • Woyach JA, Johnson AJ, Byrd JC. 2012. The B cell receptor signaling pathway as a therapeutic target in CLL. Blood 120:1175-84
    • (2012) Blood , vol.120 , pp. 1175-1184
    • Woyach, J.A.1    Johnson, A.J.2    Byrd, J.C.3
  • 93
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen L, Apgar J, Huynh L, Dicker F, Giago-McGahan T, et al. 2005. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 105:2036-41
    • (2005) Blood , vol.105 , pp. 2036-2041
    • Chen, L.1    Apgar, J.2    Huynh, L.3    Dicker, F.4    Giago-Mcgahan, T.5
  • 94
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L, Huynh L, Apgar J, Tang L, Rassenti L, et al. 2008. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 111:2685-92
    • (2008) Blood , vol.111 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3    Tang, L.4    Rassenti, L.5
  • 95
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling
    • Duhren-von Minden M, Ubelhart R, Schneider D, Wossning T, Bach MP, et al. 2012. Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling. Nature 489:309-12
    • (2012) Nature , vol.489 , pp. 309-312
    • Duhren-Von Minden, M.1    Ubelhart, R.2    Schneider, D.3    Wossning, T.4    Bach, M.P.5
  • 96
    • 64049093376 scopus 로고    scopus 로고
    • High-level expression of the T cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
    • Burger JA, Quiroga MP, Hartmann E, Burkle A, Wierda WG, et al. 2009. High-level expression of the T cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Blood 113:3050-58
    • (2009) Blood , vol.113 , pp. 3050-3058
    • Burger, J.A.1    Quiroga, M.P.2    Hartmann, E.3    Burkle, A.4    Wierda, W.G.5
  • 97
    • 46749145421 scopus 로고    scopus 로고
    • CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
    • Patten PE, Buggins AG, Richards J, Wotherspoon A, Salisbury J, et al. 2008. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood 111:5173-81
    • (2008) Blood , vol.111 , pp. 5173-5181
    • Patten, P.E.1    Buggins, A.G.2    Richards, J.3    Wotherspoon, A.4    Salisbury, J.5
  • 98
    • 0036099832 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    • Ghia P, Strola G, Granziero L, Geuna M, Guida G, et al. 2002. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur. J. Immunol. 32:1403-13
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1403-1413
    • Ghia, P.1    Strola, G.2    Granziero, L.3    Geuna, M.4    Guida, G.5
  • 99
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Perez-Galan P, Liu D, Biancotto A, Pittaluga S, et al. 2011. The lymph node microenvironment promotes B cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117:563-74
    • (2011) Blood , vol.117 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3    Biancotto, A.4    Pittaluga, S.5
  • 100
    • 0035412375 scopus 로고    scopus 로고
    • CD38 expression as an important prognostic factor in B cell chronic lymphocytic leukemia
    • Ibrahim S, Keating M, Do KA, OBrien S, Huh YO, et al. 2001. CD38 expression as an important prognostic factor in B cell chronic lymphocytic leukemia. Blood 98:181-86
    • (2001) Blood , vol.98 , pp. 181-186
    • Ibrahim, S.1    Keating, M.2    Do, K.A.3    Obrien, S.4    Huh, Y.O.5
  • 101
    • 36148992239 scopus 로고    scopus 로고
    • CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
    • Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, et al. 2007. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 110:3352-59
    • (2007) Blood , vol.110 , pp. 3352-3359
    • Damle, R.N.1    Temburni, S.2    Calissano, C.3    Yancopoulos, S.4    Banapour, T.5
  • 102
    • 77649154795 scopus 로고    scopus 로고
    • CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells
    • Deaglio S, Aydin S, Grand MM, Vaisitti T, Bergui L, et al. 2010. CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol. Med. 16:87-91
    • (2010) Mol. Med. , vol.16 , pp. 87-91
    • Deaglio, S.1    Aydin, S.2    Grand, M.M.3    Vaisitti, T.4    Bergui, L.5
  • 103
    • 79959856063 scopus 로고    scopus 로고
    • Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9
    • Buggins AG, Levi A, Gohil S, FishlockK, Patten PE, et al. 2011. Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9. Br. J. Haematol. 154:216-22
    • (2011) Br. J. Haematol. , vol.154 , pp. 216-222
    • Buggins, A.G.1    Levi, A.2    Gohil, S.3    Fishlock, K.4    Patten, P.E.5
  • 104
    • 84876037294 scopus 로고    scopus 로고
    • Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
    • Zhang S, Wu CCN, Fecteau J-F, Cui B, Chen L, et al. 2013. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44. Proc. Natl. Acad. Sci. USA 110:6127-32
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 6127-6132
    • Zhang, S.1    Wu, C.C.N.2    Fecteau, J.-F.3    Cui, B.4    Chen, L.5
  • 105
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • Burger JA, Burger M, Kipps TJ. 1999. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94:3658-67
    • (1999) Blood , vol.94 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 106
    • 35748960817 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukaemia cells show specific changes in membrane protein expression during different stages of cell cycle
    • Bennett F, Rawstron A, Plummer M, de Tute R, Moreton P, et al. 2007. B cell chronic lymphocytic leukaemia cells show specific changes in membrane protein expression during different stages of cell cycle. Br. J. Haematol. 139:600-4
    • (2007) Br. J. Haematol. , vol.139 , pp. 600-604
    • Bennett, F.1    Rawstron, A.2    Plummer, M.3    De Tute, R.4    Moreton, P.5
  • 107
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor 1
    • Burger JA, TsukadaN, BurgerM, Zvaifler NJ, DellAquila M, Kipps TJ. 2000. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor 1. Blood 96:2655-63
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dellaquila, M.5    Kipps, T.J.6
  • 108
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, et al. 2005. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106:1824-30
    • (2005) Blood , vol.106 , pp. 1824-1830
    • Burger, M.1    Hartmann, T.2    Krome, M.3    Rawluk, J.4    Tamamura, H.5
  • 109
    • 23044514711 scopus 로고    scopus 로고
    • Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α
    • Nishio M, Endo T, TsukadaN, Ohata J, Kitada S, et al. 2005. Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α. Blood 106:1012-20
    • (2005) Blood , vol.106 , pp. 1012-1020
    • Nishio, M.1    Endo, T.2    Tsukada, N.3    Ohata, J.4    Kitada, S.5
  • 110
    • 74049148128 scopus 로고    scopus 로고
    • In vivo intraclonal and interclonal kinetic heterogeneity in B cell chronic lymphocytic leukemia
    • Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, et al. 2009. In vivo intraclonal and interclonal kinetic heterogeneity in B cell chronic lymphocytic leukemia. Blood 114:4832-42
    • (2009) Blood , vol.114 , pp. 4832-4842
    • Calissano, C.1    Damle, R.N.2    Hayes, G.3    Murphy, E.J.4    Hellerstein, M.K.5
  • 111
    • 70349237504 scopus 로고    scopus 로고
    • B cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, et al. 2009. B cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 114:1029-37
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3    Sivina, M.4    Keating, M.J.5
  • 112
    • 69249120197 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B cell receptor ligation and associated with progressive disease
    • Vlad A, Deglesne PA, Letestu R, Saint-Georges S, Chevallier N, et al. 2009. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B cell receptor ligation and associated with progressive disease. Cancer Res. 69:6387-95
    • (2009) Cancer Res. , vol.69 , pp. 6387-6395
    • Vlad, A.1    Deglesne, P.A.2    Letestu, R.3    Saint-Georges, S.4    Chevallier, N.5
  • 114
    • 84876477884 scopus 로고    scopus 로고
    • Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B cell receptor signaling
    • Burger JA, Montserrat E. 2012. Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B cell receptor signaling. Blood 121:1501-9
    • (2012) Blood , vol.121 , pp. 1501-1509
    • Burger, J.A.1    Montserrat, E.2
  • 115
    • 0019052682 scopus 로고
    • Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkins lymphomas
    • SteinH, Bonk A, TolksdorfG, Lennert K, Rodt H, Gerdes J. 1980. Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkins lymphomas. J. Histochem. Cytochem. 28:746-60
    • (1980) J. Histochem. Cytochem. , vol.28 , pp. 746-760
    • Stein, H.1    Bonk, A.2    Tolksdorf, G.3    Lennert, K.4    Rodt, H.5    Gerdes, J.6
  • 116
    • 33750301858 scopus 로고    scopus 로고
    • Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkins lymphoma
    • Ruan J, HyjekE, Kermani P, Christos PJ, HooperAT, et al. 2006. Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkins lymphoma. Clin. Cancer Res. 12:5622-31
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5622-5631
    • Ruan, J.1    Hyjek, E.2    Kermani, P.3    Christos, P.J.4    Hooper, A.T.5
  • 117
    • 0036464610 scopus 로고    scopus 로고
    • Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia
    • Tsukada N, Burger JA, Zvaifler NJ, Kipps TJ. 2002. Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia. Blood 99:1030-37
    • (2002) Blood , vol.99 , pp. 1030-1037
    • Tsukada, N.1    Burger, J.A.2    Zvaifler, N.J.3    Kipps, T.J.4
  • 118
    • 78649786160 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): From understanding the basics towards therapeutic targeting
    • Burger JA. 2010. Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting. Semin. Cancer Biol. 20:424-30
    • (2010) Semin. Cancer Biol. , vol.20 , pp. 424-430
    • Burger, J.A.1
  • 119
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P, Jones D, Ganeshaguru K, Foroni L, Hoffbrand AV. 1996. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 92:97-103
    • (1996) Br. J. Haematol. , vol.92 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 120
    • 0032055818 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
    • Lagneaux L, Delforge A, Bron D, De Bruyn C, Stryckmans P. 1998. Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 91:2387-96
    • (1998) Blood , vol.91 , pp. 2387-2396
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3    De Bruyn, C.4    Stryckmans, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.