7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

Neuroscience Letters

Volumn 566, Issue , 2014, Pages 286-291

  Korkmaz, Orhan Tansel ^a,b,d   Aytan, Nurgul ^a,b   Carreras, Isabel ^a,b   Choi, Ji Kyung ^c   Kowall, Neil W ^a,b   Jenkins, Bruce G ^c   Dedeoglu, Alpaslan ^a,b,c  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

7,8 Dihydroxyflavone; Amyotrophic lateral sclerosis; BDNF; Motor neurons; TrkB

Indexed keywords

7,8 DIHYDROXYFLAVONE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL COUNT; CELL DENSITY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EFFECT; LUMBAR SPINAL CORD; MALE; MOTONEURON; MOTOR PERFORMANCE; MOUSE; MOUSE MODEL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; TRANSGENIC MOUSE;

7,8-DIHYDROXYFLAVONE; AMYOTROPHIC LATERAL SCLEROSIS; BDNF; MOTOR NEURONS; TRKB;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL COUNT; CELL SURVIVAL; DENDRITIC CELLS; FLAVANONES; HUMANS; MICE, TRANSGENIC; MOTOR NEURONS; MOTOR SKILLS; NEUROPROTECTIVE AGENTS; RECEPTOR, TRKB; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84897009107     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.02.058     Document Type: Article

References (37)

1. Rowland L.P., Shneider N.A. Amyotrophic lateral sclerosis. N. Engl. J. Med. 2001, 344:1688-1700.
2. Sathasivam S., Ince P.G., Shaw P.J. Apoptosis in amyotrophic lateral sclerosis: a review of the evidence. Neuropathol. Appl. Neurobiol. 2001, 27:257-274.
3. Cozzolino M., Ferri A., Carrì M.T. Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications. Antioxid. Redox Signal. 2008, 10:405-443.
4. Zoccolella S., Santamato A., Lamberti P. Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatr. Dis. Treat. 2009, 5:577-595.
5. Beleza-Meireles A., Al-Chalabi A. Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives. Amyotroph. Lateral Scler. 2009, 10:1-14.
6. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'regan J.P., Deng H.-X., Rahmani Z., Krizus A., Mckenna-Yasek D., Cayabyab A., Gaston S.M., Berger R., Tanzi R.E., Halperin J.J., Herzfeldt B., Van Den Bergh R., Hung W.-Y., Bird T., Deng G., Mulder D.W., Smyth C., Laing N.G., Soriano E., Pericak-Vance M.A., Haines J., Rouleau G.A., Gusella J.S., Robert Horvitz H., Brown R.H., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993, 362:59-62.
7. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 1994, 264:1772-1775.
8. Yuen E.C. The role of neurotrophic factors in disorders of peripheral nerves and motor neurons. Phys. Med. Rehabil. Clin. N. Am. 2001, 12:293-306.
9. Kaplan D.R., Miller F.D. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 2000, 10:381-391.
10. Askanas V. Neurotrophic factors and amyotrophic lateral sclerosis. Adv. Neurol. 1995, 68:241-244.
11. Siegel G.J., Chauhan N.B. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res. Rev. 2000, 33:199-227.
12. Jang S.W., Liu X., Yepes M., Shepherd K.R., Miller G.W., Liu Y., Wilson W.D., Xiao G., Blanchi B., Sun Y.E., Ye K. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:2687-2692.
13. Mantilla C.B., Ermilov L.G. The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle Nerve 2012, 45:274-276.
14. Wang X.H., Poo M.M. Potentiation of developing synapses by postsynaptic release of neurotrophin-4. Neuron 1997, 19:825-835.
15. Wang X., Berninger B., Poo M. Localized synaptic actions of neurotrophin-4. J. Neurosci. 1998, 18:4985-5499.
16. Lohof A.M., Ip N.Y., Poo M.M. Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 1993, 363:350-353.
17. Liu X., Chan C.B., Jang S.W., Pradoldej S., Huang J., He K., Phun L.H., France S., Xiao G., Jia Y., Luo H.R., Ye K. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J. Med. Chem. 2010, 53:8274-8286.
18. Andero R., Daviu N., Escorihuela R.M., Nadal R., Armario A. 7,8-Dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 2012, 22:399-408.
19. Johnson R.A., Lam M., Punzo A.M., Li H., Lin B.R., Ye K., Mitchell G.S., Chang Q. 7,8-Dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J. Appl. Physiol. 2011, 112:704-710.
20. Jiang M., Peng Q., Liu X., Jin J., Hou Z., Zhang J., Mori S., Ross C.A., Ye K., Duan W. Small-molecule TrkB receptor agonists improve motor function and extend survival in mouse model of Huntington's disease. Hum. Mol. Genet. 2013, 10.1093/hmg/ddt098.
21. Devi L., Ohno M. 7,8-Dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2012, 37:434-444.
22. Cunha C., Angelucci A., D'Antoni A., Dobrossy M.D., Dunnett S.B., Berardi N., Brambilla R. Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiol. Dis. 2009, 33(3):358-368.
23. Carreras I., Yuruker S., Aytan N., Hossain L., Choi J.K., Jenkins B.G., Kowall N.W., Dedeoglu A. Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res. 2009, 10.1016/j.brainres.2009.11.051.
24. Liu X., Qi Q., Xiao G., Li J., Luo H.R., Ye K. O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology 2013, 91:185-200.
25. Kanning K.C., Kaplan A., Henderson C.E. Motor neuron diversity in development and disease. Annu. Rev. Neurosci. 2010, 33:409-440.
26. Purves D., Augustine G.J., Fitzpatrick D., Hall W.C., LaMantia A.-S., White L.E. Neuroscience 2012, Sinauer Associates, Sunderland, MA, Chapter 16. fifth ed.
27. Burke R.E. Motor unit types: functional specializations in motor control. Trends Neurosci. 1980, 3:255-258.
28. Swash M., Fox K.P. The pathology of the muscle spindle: effect of denervation. J. Neurol. Sci. 1974, 22:1-124.
29. Mohajeri M.H., Figlewicz D.A., Bohn M.C. Selective loss of alpha motoneurons innervating the medial gastrocnemius muscle in a mouse model of amyotrophic lateral sclerosis. Exp. Neurol. 1998, 150:329-336.
30. Copray S., Kernell D. Neurotrophins and trk-receptors in adult rat spinal motoneurons: differences related to cell size but not to 'slow/fast' specialization. Neurosci. Lett. 2000, 289:217-220.
31. Nagappan G., Lu B. Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci. 2005, 28(9):464-471.
32. Bramham C.R., Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol. 2005, 76:99-125.
33. Poo M.M. Neurotrophins as synaptic modulators. Nat. Rev. Neurosci. 2001, 2:24-32.
34. Alonso M., Medina J.H., Pozzo-Miller L. ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons. Learn. Mem. 2004, 11:172-178.
35. Zeng Y., Lv F., Li L., Yu H., Dong M., Fu Q. 7,8-Dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J. Neurochem. 2012, 122:800-811.
36. Gray E.G. Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 1959, 183:1592-1593.
37. Yuste R. Dendritic spines and distributed circuits. Neuron 2011, 71:772-781.