Neurotrophins and trk-receptors in adult rat spinal motoneurons: Differences related to cell size but not to 'slow/fast' specialization

Neuroscience Letters

Volumn 289, Issue 3, 2000, Pages 217-220

  Copray, Sjef ^a   Kernell, Daniel ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Brain derived neurotrophic factor; In situ hybridization; Motor unit; Neurotrophic factors; NT 3; NT 4; Trk receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROTROPHIN; RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SIZE; FEMALE; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; CELL SIZE; FEMALE; MOTOR NEURONS; MUSCLE FIBERS, FAST-TWITCH; MUSCLE FIBERS, SLOW-TWITCH; NERVE GROWTH FACTORS; NEUROTROPHIN 3; RATS; RATS, WISTAR; RECEPTOR, TRKB; RECEPTOR, TRKC; RNA, MESSENGER; SPINAL CORD;

EID: 0034637034     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01305-7     Document Type: Article

References (26)

1. Ariano M.A., Armstrong R.B., Edgerton V.R. Hindlimb muscle fiber populations of five mammals. J. Histochem. Cytochem. 21:1979;51-55.
2. Buck C.R., Seburn K.L., Cope T.C. Neurotrophin expression by spinal motoneurons in adult and developing rats. J. Comp. Neurol. 416:2000;309-318.
3. Copray J.C.V.M., Brouwer N. Selective expression of neurotrophin-3 messenger RNA in muscle spindles of the rat. Neuroscience. 63:1994;1125-1135.
4. Copray J.C.V.M., Mantingh-Otter I.J., Brouwer N., Kernell D. The expression of neurotrophins and their receptors in motoneurons of the rat. Soc. Neurosci. Abstr. 27:1997;1359.
5. Ernfors P., Lee K.F., Kucera J., Jaenisch R. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell. 77:1994;503-512.
6. Funakoshi H., Frisen J., Barbany G., Timmusk T., Zachrisson O., Verge V.M.K., Persson H. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123:1993;455-465.
7. Funakoshi H., Belluardo N., Arenas E., Yamamoto Y., Casabona A., Persson H., Ibanez C.F. Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons. Science. 268:1995;1495-1499.
8. Gonzalez M., Collins W.F. III. Peripheral application of NT-4 increases excitability and decreases somal size of gastrocnemius motoneurons in the adult rat. Soc. Neurosci. Abstr. 22:1996;992.
9. Gonzalez M., Collins W.F. III. Modulation of motoneuron excitability by brain-derived neurotrophic factor. J. Neurophysiol. 77:1997;502-506.
10. Griesbeck O., Parsadanian A.S., Sendtner M., Thoenen H. Expression of neurotrophins in skeletal muscle: quantitative comparison and significance for motoneuron survival and maintenance of function. J. Neurosci. Res. 42:1995;21-33.
11. Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., Le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. 89:1992;3060-3064.
12. Ishihara A., Naitoh H., Araki H., Nishihira Y. Soma size and oxidative enzyme activity of motoneurones supplying the fast and slow twitch muscles in the rat. Brain Res. 446:1988;195-198.
13. Kernell D., Bakels R., Copray J.C.V.M. Discharge properties of motoneurones: how are they matched to the properties and use of their muscle units? J. Physiol. (Paris). 1999;87-96.
14. Kucera J., Ernfors P., Walro J., Jaenisch R. Reduction in the number of spinal motor neurons in neurotrophin-3-dependent mice. Neuroscience. 69:1995;321-330.
15. Maisonpierre P.C., Le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., De la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics. 10:1991;558-568.
16. Mendell L.M., Johnson R.D., Munson J.B. Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection. J. Neurosci. 19:1999;3162-3170.
17. Merlio J.P., Ernfors P., Jaber M., Persson H. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience. 51:1992;513-532.
18. Middlemas D.S., Lindberg R.A., Hunter T. TrkB, a neural receptor protein-kinase: evidence for a full-length and two truncated receptors. Mol. Cell Biol. 11:1991;143-153.
19. Munson J.B., Shelton D.L., McMahon S.B. Adult mammalian sensory and motor neurons: roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy. J. Neurosci. 17:1997;470-476.
20. Munson J.B., Johnson R.D., Mendell L.M. NT-3 increases amplitude of EPSP's produced by axotomized group Ia afferents. J. Neurophysiol. 77:1997;2209-2212.
21. Scarisbrick I.A., Isackson P.J., Windebank A.J. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid. J. Neurosci. 18:1999;7757-7769.
22. Sickles D.W., Oblak T.G. A horseradish peroxidase labeling technique for correlation of motoneuron metabolic activity with muscle fiber types. J. Neurosci. Methods. 7:1983;195-201.
23. Seebach B.S., Arvanov V., Mendell L.M. Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. J. Neurophysiol. 18:1999;2398-2405.
24. Sterne G.D., Coulton G.R., Brown R.A., Green C.J., Terenghi G. Neurotrophin-3 enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b. J. Cell. Biol. 139:1997;709-715.
25. Valenzuela D.M., Maisonpierre P.C., Glass D.J., Rojas E., Nunez L., Kong Y., Gies D.R., Stitt T.N., Ip N.Y., Yancopoulos G.D. Alternative forms of rat trkC with different functional capabilities. Neuron. 10:1993;963-974.
26. Vult von Steyern F., Martinov V., Rabben I., Nja A., de Lapeyriere O., Lomo T. The homeodomain transcription factors Islet 1 and HB are expressed in adult alpha and gamma motoneurons identified by selective retrograde tracing. Eur. J. Neurosci. 11:1999;2093-2102.