Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinoma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Liu, Xiao ^a   Huang, Yu ^a   Yang, Dinghua ^a   Li, Xianghong ^a   Liang, Jiankun ^a   Lin, Liang ^a   Zhang, Meng ^a   Zhong, Kebo ^a   Liang, Bo ^a   Li, Jialu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASPASE 8; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION INTERMEDIARY FACTOR 1 ALPHA; TRIM24 PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ADULT; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENVIRONMENTAL FACTOR; EPIGENETICS; FEMALE; HEREDITY; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PATHOGENESIS; PROTEIN EXPRESSION; SURVIVAL TIME; TUMOR CELL; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84897002465     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085462     Document Type: Article

References (27)

1. Marrero JA (2006) Hepatocellular carcinoma. Curr Opin Gastroenterol 22: 248-253.
2. Motola-Kuba D, Zamora-Valdes D, Uribe M, Mendez-Sanchez N (2006) Hepatocellular carcinoma. An overview. Ann Hepatol 5: 16-24.
3. Mann CD, Neal CP, Garcea G, Manson MM, Dennison AR, et al. (2007) Prognostic molecular markers in hepatocellular carcinoma: a systematic review. Eur J Cancer 43: 979-992.
4. Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, et al. (2008) Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg 143: 182-188; discussion 188.
5. Sumie S, Kuromatsu R, Okuda K, Ando E, Takata A, et al. (2008) Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors. Ann Surg Oncol 15: 1375-1382.
6. Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J 15: 6701-6715.
7. Le Douarin B, Nielsen AL, You J, Chambon P, Losson R (1997) TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2of nuclear receptors? Biochem Soc Trans 25: 605-612.
8. Le Douarin B, Zechel C, Garnier JM, Lutz Y, Tora L, et al. (1995) The Nterminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J 14: 2020-2033.
9. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, et al. (2009) Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A 106: 11612-11616.
10. Jain AK, Barton MC (2009) Regulation of p53: TRIM24 enters the RING. Cell Cycle 8: 3668-3674.
11. Katzenellenbogen BS (1996) Estrogen receptors: bioactivities and interactions with cell signaling pathways. Biol Reprod 54: 287-293.
12. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, et al. (2010) TRIM24 links a non-canonical histone signature to breast cancer. Nature 468: 927-932.
13. Belloni E, Trubia M, Gasparini P, Micucci C, Tapinassi C, et al. (2005) 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes Chromosomes Cancer 42: 320-325.
14. Klugbauer S, Rabes HM (1999) The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Oncogene 18: 4388-4393.
15. Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, et al. (1999) A RAdependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet 23: 287-295.
16. Chambon M, Orsetti B, Berthe ML, Bascoul-Mollevi C, Rodriguez C, et al. (2011) Prognostic significance of TRIM24/TIF-1alpha gene expression in breast cancer. Am J Pathol 178: 1461-1469.
17. Li H, Sun L, Tang Z, Fu L, Xu Y, et al. (2012) Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer. PLoS One 7: e37657.
18. Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, et al. (2011) Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A 108: 8212-8217.
19. Le Douarin B, You J, Nielsen AL, Chambon P, Losson R (1998) TIF1alpha: a possible link between KRAB zinc finger proteins and nuclear receptors. J Steroid Biochem Mol Biol 65: 43-50.
20. Khetchoumian K, Teletin M, Tisserand J, Herquel B, Ouararhni K, et al. (2008) Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer. Cell Cycle 7: 3647-3652.
21. Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, et al. (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet 39: 1500-1506.
22. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, et al. (2012) p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol 10: e1001268.
23. Knudsen KE, Diehl JA, Haiman CA, Knudsen ES (2006) Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 25: 1620-1628.
24. Keum JS, Kong G, Yang SC, Shin DH, Park SS, et al. (1999) Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer. Br J Cancer 81: 127-132.
25. Ratschiller D, Heighway J, Gugger M, Kappeler A, Pirnia F, et al. (2003) Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival. J Clin Oncol 21: 2085-2093.
26. Roy PG, Thompson AM (2006) Cyclin D1 and breast cancer. Breast 15: 718-727.
27. Greenburg G, Hay ED (1982) Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 95: 333-339.