HnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1839, Issue 4, 2014, Pages 306-315

  Cho, Sunghee ^a   Moon, Heegyum ^a   Loh, Tiing Jen ^a   Oh, Huyn Kyung ^a   Cho, Sungchan ^b   Choy, Hyon E ^c   Song, Woo Keun ^a   Chun, Jang Soo ^a   Zheng, Xuexiu ^a   Shen, Haihong ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chonnam National University Medical School   (South Korea)

Author keywords

Exon 7; HnRNP M; Pre mRNA splicing; SMN2; Spinal muscular atrophy

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M; MESSENGER RNA PRECURSOR; RESTRICTION ENDONUCLEASE; SHORT HAIRPIN RNA; SURVIVAL MOTOR NEURON PROTEIN 1; SURVIVAL MOTOR NEURON PROTEIN 2;

ARTICLE; BINDING SITE; CELL CULTURE; CROSS LINKING; DNA FLANKING REGION; ENHANCER REGION; EXON; EXON SKIPPING; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; INTRON; MUTAGENESIS; NEUROMUSCULAR FACILITATION; PLASMID; POINT MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA BINDING; RNA SEQUENCE; RNA SPLICING; SPINAL MUSCULAR ATROPHY; ULTRAVIOLET RADIATION;

EXON 7; HNRNP M; PRE-MRNA SPLICING; SMN2; SPINAL MUSCULAR ATROPHY;

ANTERIOR HORN CELLS; CELL CULTURE TECHNIQUES; ENHANCER ELEMENTS, GENETIC; EXONS; GENE EXPRESSION REGULATION; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP M; MOLECULAR TARGETED THERAPY; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA-BINDING PROTEINS; SPINAL CORD; SURVIVAL OF MOTOR NEURON 1 PROTEIN; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 84896983805     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2014.02.006     Document Type: Article

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