SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2β1

Human Molecular Genetics

Volumn 11, Issue 5, 2002, Pages 577-587

  Young, Philip J ^a   DiDonato, Christine J ^b   Hu, Diane ^a   Kothary, Rashmi ^b   Androphy, Elliot J ^c   Lorson, Christian L ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GUANINE; NUCLEOTIDE; RECOMBINANT PROTEIN; REGULATOR PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENHANCER REGION; EXON; GENE CONTROL; GENE LOSS; GENETIC TRANSCRIPTION; HOMOZYGOSITY; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; SPINAL MUSCULAR ATROPHY;

ALTERNATIVE SPLICING; BASE SEQUENCE; BINDING SITES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENHANCER ELEMENTS (GENETICS); EXONS; HELA CELLS; HUMANS; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; RNA; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036501065     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

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2. Classification of spinal muscular atrophies
3. A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2
4. A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
5. An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN
6. SMN oligomerization defect correlates with spinal muscular atrophy severity
7. Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMNT and SMNC gene copy number
8. The survival motor neuron protein in spinal muscular atrophy
9. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy
10. A mouse model for spinal muscular atrophy
11. The structure and function of proteins involved in mammalian pre-mRNA splicing
12. SR-related proteins and the processing of messenger RNA precursors
13. The superfamily of arginine/serine-rich splicing factors
14. SR proteins and splicing control
15. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
16. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
17. Genetic analysis of the SR protein ASF/SF2: Interchangeability of RS domains and negative control of splicing
18. Pre-mRNA splicing in the absence of an SR protein RS domain
19. Identification of a new class of exonic splicing enhancers by in vivo selection
20. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins
21. Exonic splicing enhancer motif recognized by human SC35 under splicing conditions
22. Selection and characterization of pre-mRNA splicing enhancers: Identification of novel SR protein-specific enhancer sequences
23. Selection of novel exon recognition elements from a pool of random sequences
24. Positive control of pre-mRNA splicing in vitro
25. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity
26. The role of exon sequences in splice site selection
27. Structural functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers
28. Synergistic interactions between two distinct elements of a regulated splicing enhancer
29. Htra2-βl stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)
30. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c
31. The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins
32. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
33. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2β and affect splicing
34. Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients
35. Activity-dependent regulation of alternative splicing patterns in the rat brain
36. Molecular cloning of htra2-β-1 and htra2-β-2, two human homologs of tra-2 generated by alternative splicing
37. Functions of SR and Tra2 proteins in pre-mRNA splicing regulation
38. A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
39. The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding