Essential role for the SMN complex in the specificity of snRNP assembly

Science

Volumn 298, Issue 5599, 2002, Pages 1775-1779

  Pellizzoni, Livio ^b   Yong, Jeongsik ^a   Dreyfuss, Gideon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; MUSCLE; PURIFICATION; RNA;

ORDERED BINDING;

PROTEINS;

CELL EXTRACT; GENE PRODUCT; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG;

PROTEIN; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL PROTECTION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; GENE ISOLATION; MACROMOLECULE; MOTONEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PURIFICATION; RNA ANALYSIS; SPINAL MUSCULAR ATROPHY;

ADENOSINE TRIPHOSPHATE; CARRIER PROTEINS; CELL EXTRACTS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEAD-BOX RNA HELICASES; HELA CELLS; HUMANS; KINETICS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OLIGORIBONUCLEOTIDES; PROTEIN BINDING; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA HELICASES; RNA, SMALL NUCLEAR; RNA-BINDING PROTEINS;

ANIMALIA;

EID: 2242443509     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074962     Document Type: Article

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46. We thank members of our laboratory, in particular A. Gubitz, J. Baccon, and S. Paushkin, for stimulating discussions and for critical comments on this manuscript. We are grateful to J. Steitz for the anti-Sm Y12 monoclonal antibody. Supported by the Association Francaise Contre les Myopathies and by a grant from NIH. G.D. is an investigator of the Howard Hughes Medical Institute.