메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR;

EID: 84896980415     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084268     Document Type: Article
Times cited : (28)

References (45)
  • 1
    • 65249101260 scopus 로고    scopus 로고
    • The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    • Montini E, Cesana D, Schmidt M, Sanvito F, Bartholomae CC, et al. (2009) The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J Clin Invest 119: 964-975.
    • (2009) J Clin Invest , vol.119 , pp. 964-975
    • Montini, E.1    Cesana, D.2    Schmidt, M.3    Sanvito, F.4    Bartholomae, C.C.5
  • 2
    • 78650918644 scopus 로고    scopus 로고
    • Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
    • Santilli G, Almarza E, Brendel C, Choi U, Beilin C, et al. (2011) Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther 19: 122-132.
    • (2011) Mol Ther , vol.19 , pp. 122-132
    • Santilli, G.1    Almarza, E.2    Brendel, C.3    Choi, U.4    Beilin, C.5
  • 3
    • 34247146896 scopus 로고    scopus 로고
    • Stable gene expression occurs from a minority of integrated HIV-1-based vectors: Transcriptional silencing is present in the majority
    • DOI 10.1038/sj.gt.3302923, PII 3302923
    • Mok HP, Javed S, Lever A (2007) Stable gene expression occurs from a minority of integrated HIV-1-based vectors: transcriptional silencing is present in the majority. Gene Ther 14: 741-751. (Pubitemid 46585655)
    • (2007) Gene Therapy , vol.14 , Issue.9 , pp. 741-751
    • Mok, H.P.1    Javed, S.2    Lever, A.3
  • 4
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • Ellis J (2005) Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther 16: 1241-1246.
    • (2005) Hum Gene Ther , vol.16 , pp. 1241-1246
    • Ellis, J.1
  • 5
    • 84863214203 scopus 로고    scopus 로고
    • Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site
    • Senigl F, Auxt M, Hejnar J (2012) Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site. Nucleic Acids Res 40: 5298-5312.
    • (2012) Nucleic Acids Res , vol.40 , pp. 5298-5312
    • Senigl, F.1    Auxt, M.2    Hejnar, J.3
  • 7
    • 51349090473 scopus 로고    scopus 로고
    • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
    • Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, et al. (2008) Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 118: 3132-3142.
    • (2008) J Clin Invest , vol.118 , pp. 3132-3142
    • Hacein-Bey-Abina, S.1    Garrigue, A.2    Wang, G.P.3    Soulier, J.4    Lim, A.5
  • 8
    • 76249131912 scopus 로고    scopus 로고
    • Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
    • Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, et al. (2010) Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 16: 198-204.
    • (2010) Nat Med , vol.16 , pp. 198-204
    • Stein, S.1    Ott, M.G.2    Schultze-Strasser, S.3    Jauch, A.4    Burwinkel, B.5
  • 9
    • 84862829833 scopus 로고    scopus 로고
    • Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo
    • Herbst F, Ball CR, Tuorto F, Nowrouzi A, Wang W, et al. (2012) Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo. Mol Ther 20: 1014-1021.
    • (2012) Mol Ther , vol.20 , pp. 1014-1021
    • Herbst, F.1    Ball, C.R.2    Tuorto, F.3    Nowrouzi, A.4    Wang, W.5
  • 10
    • 79953308066 scopus 로고    scopus 로고
    • Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells
    • Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM (2011) Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther 19: 768-781.
    • (2011) Mol Ther , vol.19 , pp. 768-781
    • Dravid, G.1    Zhu, Y.2    Scholes, J.3    Evseenko, D.4    Crooks, G.M.5
  • 11
    • 73649090756 scopus 로고    scopus 로고
    • Identification of a functional network of human epigenetic silencing factors
    • Poleshko A, Einarson MB, Shalginskikh N, Zhang R, Adams PD, et al. (2010) Identification of a functional network of human epigenetic silencing factors. J Biol Chem 285: 422-433.
    • (2010) J Biol Chem , vol.285 , pp. 422-433
    • Poleshko, A.1    Einarson, M.B.2    Shalginskikh, N.3    Zhang, R.4    Adams, P.D.5
  • 12
    • 0037240651 scopus 로고    scopus 로고
    • High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors
    • Ma Y, Ramezani A, Lewis R, Hawley RG, Thomson JA (2003) High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells 21: 111-117. (Pubitemid 36120372)
    • (2003) Stem Cells , vol.21 , Issue.1 , pp. 111-117
    • Ma, Y.1    Ramezani, A.2    Lewis, R.3    Hawley, R.G.4    Thomson, J.A.5
  • 13
    • 34547117857 scopus 로고    scopus 로고
    • Transient and stable transgene expression in human embryonic stem cells
    • DOI 10.1634/stemcells.2006-0634
    • Liew CG, Draper JS, Walsh J, Moore H, Andrews PW (2007) Transient and stable transgene expression in human embryonic stem cells. Stem Cells 25: 1521-1528. (Pubitemid 47106021)
    • (2007) Stem Cells , vol.25 , Issue.6 , pp. 1521-1528
    • Liew, C.-G.1    Draper, J.S.2    Walsh, J.3    Moore, H.4    Andrews, P.W.5
  • 16
    • 24344510293 scopus 로고    scopus 로고
    • Chromatin domain boundaries: Insulators and beyond
    • DOI 10.1038/sj.cr.7290298
    • Wei GH, Liu DP, Liang CC (2005) Chromatin domain boundaries: insulators and beyond. Cell Res 15: 292-300. (Pubitemid 41642885)
    • (2005) Cell Research , vol.15 , Issue.4 , pp. 292-300
    • Wei, G.H.1    Liu, D.P.2    Liang, C.C.3
  • 17
    • 0030667648 scopus 로고    scopus 로고
    • Stem cell gene therapy, position effects and chromatin insulators
    • Neff T, Shotkoski F, Stamatoyannopoulos G (1997) Stem cell gene therapy, position effects and chromatin insulators. Stem Cells 15 Suppl 1: 265-271.
    • (1997) Stem Cells , vol.15 , Issue.SUPPL. 1 , pp. 265-271
    • Neff, T.1    Shotkoski, F.2    Stamatoyannopoulos, G.3
  • 19
    • 84857321616 scopus 로고    scopus 로고
    • Chromatin insulator elements: Establishing barriers to set heterochromatin boundaries
    • Barkess G, West AG (2012) Chromatin insulator elements: establishing barriers to set heterochromatin boundaries. Epigenomics 4: 67-80.
    • (2012) Epigenomics , vol.4 , pp. 67-80
    • Barkess, G.1    West, A.G.2
  • 21
    • 0034000919 scopus 로고    scopus 로고
    • The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites
    • DOI 10.1128/JVI.74.10.4679-4687.2000
    • Rivella S, Callegari JA, May C, Tan CW, Sadelain M (2000) The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites. J Virol 74: 4679-4687. (Pubitemid 30237894)
    • (2000) Journal of Virology , vol.74 , Issue.10 , pp. 4679-4687
    • Rivella, S.1    Callegari, J.A.2    May, C.3    Tan, C.W.4    Sadelain, M.5
  • 22
    • 39549110741 scopus 로고    scopus 로고
    • An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
    • DOI 10.1182/blood-2007-04-085506
    • Ryu BY, Evans-Galea MV, Gray JT, Bodine DM, Persons DA, et al. (2008) An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation. Blood 111: 1866-1875. (Pubitemid 351451495)
    • (2008) Blood , vol.111 , Issue.4 , pp. 1866-1875
    • Ryu, B.Y.1    Evans-Galea, M.V.2    Gray, J.T.3    Bodine, D.M.4    Persons, D.A.5    Nienhuis, A.W.6
  • 23
    • 63949083133 scopus 로고    scopus 로고
    • Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
    • Li CL, Xiong D, Stamatoyannopoulos G, Emery DW (2009) Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther 17: 716-724.
    • (2009) Mol Ther , vol.17 , pp. 716-724
    • Li, C.L.1    Xiong, D.2    Stamatoyannopoulos, G.3    Emery, D.W.4
  • 24
    • 69949150240 scopus 로고    scopus 로고
    • Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3′LTR
    • Urbinati F, Arumugam P, Higashimoto T, Perumbeti A, Mitts K, et al. (2009) Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3′LTR. Mol Ther 17: 1527-1536.
    • (2009) Mol Ther , vol.17 , pp. 1527-1536
    • Urbinati, F.1    Arumugam, P.2    Higashimoto, T.3    Perumbeti, A.4    Mitts, K.5
  • 25
    • 78650874241 scopus 로고    scopus 로고
    • Chicken HS4 insulators have minimal barrier function among progeny of human hematopoietic cells transduced with an HIV1-based lentiviral vector
    • Uchida N, Washington KN, Lap CJ, Hsieh MM, Tisdale JF (2011) Chicken HS4 insulators have minimal barrier function among progeny of human hematopoietic cells transduced with an HIV1-based lentiviral vector. Mol Ther 19: 133-139.
    • (2011) Mol Ther , vol.19 , pp. 133-139
    • Uchida, N.1    Washington, K.N.2    Lap, C.J.3    Hsieh, M.M.4    Tisdale, J.F.5
  • 27
    • 70349185586 scopus 로고    scopus 로고
    • The 3′ region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity
    • Arumugam PI, Urbinati F, Velu CS, Higashimoto T, Grimes HL, et al. (2009) The 3′ region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PLoS One 4: e6995.
    • (2009) PLoS One , vol.4
    • Arumugam, P.I.1    Urbinati, F.2    Velu, C.S.3    Higashimoto, T.4    Grimes, H.L.5
  • 28
    • 0035342360 scopus 로고    scopus 로고
    • Progress toward vector design for hematopoietic stem cell gene therapy
    • Hawley RG (2001) Progress toward vector design for hematopoietic stem cell gene therapy. Curr Gene Ther 1: 1-17.
    • (2001) Curr Gene Ther , vol.1 , pp. 1-17
    • Hawley, R.G.1
  • 30
    • 0031958593 scopus 로고    scopus 로고
    • Scaffold attachment region-mediated enhancement retroviral vector expression in primary T cells
    • Agarwal M, Austin TW, Morel F, Chen J, Bohnlein E, et al. (1998) Scaffold attachment region-mediated enhancement of retroviral vector expression in primary T cells. J Virol 72: 3720-3728. (Pubitemid 28188670)
    • (1998) Journal of Virology , vol.72 , Issue.5 , pp. 3720-3728
    • Agarwal, M.1    Austin, T.W.2    Morel, F.3    Chen, J.4    Bohnlein, E.5    Plavec, I.6
  • 31
    • 0034088115 scopus 로고    scopus 로고
    • Human beta interferon scaffold attachment region inhibits de novo methylation and confers long-term, copy number-dependent expression to a retroviral vector
    • DOI 10.1128/JVI.74.6.2671-2678.2000
    • Dang Q, Auten J, Plavec I (2000) Human beta interferon scaffold attachment region inhibits de novo methylation and confers long-term, copy number-dependent expression to a retroviral vector. J Virol 74: 2671-2678. (Pubitemid 30117577)
    • (2000) Journal of Virology , vol.74 , Issue.6 , pp. 2671-2678
    • Dang, Q.1    Auten, J.2    Plavec, I.3
  • 32
    • 0038792207 scopus 로고    scopus 로고
    • Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator
    • Ramezani A, Hawley TS, Hawley RG (2003) Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator. Blood 101: 4717-4724. (Pubitemid 36857727)
    • (2003) Blood , vol.101 , Issue.12 , pp. 4717-4724
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 33
    • 0034849315 scopus 로고    scopus 로고
    • Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo
    • DOI 10.1006/mthe.2001.0450
    • Park F, Kay MA (2001) Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo. Mol Ther 4: 164-173. (Pubitemid 32851279)
    • (2001) Molecular Therapy , vol.4 , Issue.3 , pp. 164-173
    • Park, F.1    Kay, M.A.2
  • 34
    • 0026697332 scopus 로고
    • Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate
    • Klehr D, Schlake T, Maass K, Bode J (1992) Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate. Biochemistry 31: 3222-3229.
    • (1992) Biochemistry , vol.31 , pp. 3222-3229
    • Klehr, D.1    Schlake, T.2    Maass, K.3    Bode, J.4
  • 35
    • 79955852358 scopus 로고    scopus 로고
    • The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
    • Emery DW (2011) The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 22: 761-774.
    • (2011) Hum Gene Ther , vol.22 , pp. 761-774
    • Emery, D.W.1
  • 36
    • 34548791721 scopus 로고    scopus 로고
    • Improved Human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element
    • DOI 10.1038/sj.mt.6300259, PII 6300259
    • Arumugam PI, Scholes J, Perelman N, Xia P, Yee JK, et al. (2007) Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element. Mol Ther 15: 1863-1871. (Pubitemid 47434195)
    • (2007) Molecular Therapy , vol.15 , Issue.10 , pp. 1863-1871
    • Arumugam, P.I.1    Scholes, J.2    Perelman, N.3    Xia, P.4    Yee, J.-K.5    Malik, P.6
  • 37
    • 84862829833 scopus 로고    scopus 로고
    • Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo
    • Herbst F, Ball CR, Tuorto F, Nowrouzi A, Wang W, et al. (2012) Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo. Mol Ther 20: 1014-1021.
    • (2012) Mol Ther , vol.20 , pp. 1014-1021
    • Herbst, F.1    Ball, C.R.2    Tuorto, F.3    Nowrouzi, A.4    Wang, W.5
  • 38
    • 63449134700 scopus 로고    scopus 로고
    • The functional role of S/MARs in episomal vectors as defined by the stress-induced destabilization profile of the vector sequences
    • Giannakopoulos A, Stavrou EF, Zarkadis I, Zoumbos N, Thrasher AJ, et al. (2009) The functional role of S/MARs in episomal vectors as defined by the stress-induced destabilization profile of the vector sequences. J Mol Biol 387: 1239-1249.
    • (2009) J Mol Biol , vol.387 , pp. 1239-1249
    • Giannakopoulos, A.1    Stavrou, E.F.2    Zarkadis, I.3    Zoumbos, N.4    Thrasher, A.J.5
  • 39
    • 0036099418 scopus 로고    scopus 로고
    • Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors
    • DOI 10.1006/mthe.2002.0582
    • Yannaki E, Tubb J, Aker M, Stamatoyannopoulos G, Emery DW (2002) Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors. Mol Ther 5: 589-598. (Pubitemid 34546089)
    • (2002) Molecular Therapy , vol.5 , Issue.5 I , pp. 589-598
    • Yannaki, E.1    Tubb, J.2    Aker, M.3    Stamatoyannopoulos, G.4    Emery, D.W.5
  • 40
    • 70349911175 scopus 로고    scopus 로고
    • Gene therapy for Chonic Granulomatous Disease: Current status of the german clinical study
    • Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, et al. (2008) Gene therapy for Chonic Granulomatous Disease: Current status of the german clinical study. Human Gene Therapy 19: 1097.
    • (2008) Human Gene Therapy , vol.19 , pp. 1097
    • Stein, S.1    Ott, M.G.2    Schultze-Strasser, S.3    Jauch, A.4    Burwinkel, B.5
  • 41
    • 67651100785 scopus 로고    scopus 로고
    • Mesenchymal stem cells facilitate the derivation of human embryonic stem cells from cryopreserved poor-quality embryos
    • Cortes JL, Sanchez L, Ligero G, Gutierrez-Aranda I, Catalina P, et al. (2009) Mesenchymal stem cells facilitate the derivation of human embryonic stem cells from cryopreserved poor-quality embryos. Hum Reprod 24: 1844-1851.
    • (2009) Hum Reprod , vol.24 , pp. 1844-1851
    • Cortes, J.L.1    Sanchez, L.2    Ligero, G.3    Gutierrez-Aranda, I.4    Catalina, P.5
  • 42
    • 84862249843 scopus 로고    scopus 로고
    • Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors
    • Munoz P, Toscano MG, Real PJ, Benabdellah K, Cobo M, et al. (2012) Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors. PLoS One 7: e39091.
    • (2012) PLoS One , vol.7
    • Munoz, P.1    Toscano, M.G.2    Real, P.J.3    Benabdellah, K.4    Cobo, M.5
  • 43
    • 80051900035 scopus 로고    scopus 로고
    • Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines
    • Benabdellah K, Cobo M, Munoz P, Toscano MG, Martin F (2011) Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines. PLoS One 6: e23734.
    • (2011) PLoS One , vol.6
    • Benabdellah, K.1    Cobo, M.2    Munoz, P.3    Toscano, M.G.4    Martin, F.5
  • 45
    • 55049131935 scopus 로고    scopus 로고
    • OP9 stroma augments survival of hematopoietic precursors and progenitors during hematopoietic differentiation from human embryonic stem cells
    • Ji J, Vijayaragavan K, Bosse M, Menendez P, Weisel K, et al. (2008) OP9 stroma augments survival of hematopoietic precursors and progenitors during hematopoietic differentiation from human embryonic stem cells. Stem Cells 26: 2485-2495.
    • (2008) Stem Cells , vol.26 , pp. 2485-2495
    • Ji, J.1    Vijayaragavan, K.2    Bosse, M.3    Menendez, P.4    Weisel, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.