-
1
-
-
84874640697
-
New insights and emerging therapies for breast cancer brain metastases
-
663
-
Lim E, Lin NU. New insights and emerging therapies for breast cancer brain metastases. Oncology (Williston Park). 2012;26:652-659, 663.
-
(2012)
Oncology (Williston Park).
, vol.26
, pp. 652-659
-
-
Lim, E.1
Lin, N.U.2
-
2
-
-
44649105611
-
Brain metastases in breast cancer: Clinical and pathologic characteristics associated with improvements in survival
-
Melisko ME, Moore DH, Sneed PK, et al. Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival. J Neurooncol. 2008;88:359-365.
-
(2008)
J Neurooncol.
, vol.88
, pp. 359-365
-
-
Melisko, M.E.1
Moore, D.H.2
Sneed, P.K.3
-
3
-
-
0038010542
-
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma
-
Bendell JC, Domchek SM, Burstein HJ, et al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003;97:2972-2977.
-
(2003)
Cancer.
, vol.97
, pp. 2972-2977
-
-
Bendell, J.C.1
Domchek, S.M.2
Burstein, H.J.3
-
4
-
-
84872018758
-
Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the pre-trastuzumab and trastuzumab eras
-
Karam I, Hamilton S, Nichol A, et al. Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the pre-trastuzumab and trastuzumab eras. Radiat Oncol. 2013;8:12.
-
(2013)
Radiat Oncol.
, vol.8
, pp. 12
-
-
Karam, I.1
Hamilton, S.2
Nichol, A.3
-
5
-
-
3042701597
-
Epothilones: Mechanism of action and biologic activity
-
Goodin S, Kane MP, Rubin EH. Epothilones: mechanism of action and biologic activity. J Clin Oncol. 2004;22:2015-2025.
-
(2004)
J Clin Oncol.
, vol.22
, pp. 2015-2025
-
-
Goodin, S.1
Kane, M.P.2
Rubin, E.H.3
-
6
-
-
3843053396
-
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
-
Nettles JH, Li H, Cornett B, et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science. 2004;305: 866-869.
-
(2004)
Science.
, vol.305
, pp. 866-869
-
-
Nettles, J.H.1
Li, H.2
Cornett, B.3
-
7
-
-
0034678986
-
Epothilones and related structures - A new class of microtubule inhibitors with potent in vivo antitumor activity
-
Altmann KH, Wartmann M, O'Reilly T. Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim Biophys Acta. 2000;1470:M79-M91.
-
(2000)
Biochim Biophys Acta.
, vol.1470
-
-
Altmann, K.H.1
Wartmann, M.2
O'reilly, T.3
-
8
-
-
71249103102
-
Novel microtubule-targeting agents - The epothilones
-
Cheng KL, Bradley T, Budman DR. Novel microtubule-targeting agents - the epothilones. Biologics. 2008;2:789-811.
-
(2008)
Biologics.
, vol.2
, pp. 789-811
-
-
Cheng, K.L.1
Bradley, T.2
Budman, D.R.3
-
9
-
-
0031027531
-
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxolw)
-
Kowalski RJ, Giannakakou P, Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxolw). J Biol Chem. 1997;272:2534-2541.
-
(1997)
J Biol Chem.
, vol.272
, pp. 2534-2541
-
-
Kowalski, R.J.1
Giannakakou, P.2
Hamel, E.3
-
10
-
-
51849114328
-
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo
-
O'Reilly T, Wartmann M, Brueggen J, et al. Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother Pharmacol. 2008;62:1045-1054.
-
(2008)
Cancer Chemother Pharmacol.
, vol.62
, pp. 1045-1054
-
-
O'reilly, T.1
Wartmann, M.2
Brueggen, J.3
-
11
-
-
33644831567
-
Phase i dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors
-
Rubin EH, Rothermel J, Tesfaye F, et al. Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J Clin Oncol. 2005;23:9120-9129.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 9120-9129
-
-
Rubin, E.H.1
Rothermel, J.2
Tesfaye, F.3
-
12
-
-
78751521502
-
Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: A phase i clinical trial
-
Tsimberidou AM, Takimoto CH, Moulder S, et al. Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial. Mol Cancer Ther. 2011;10:209-217.
-
(2011)
Mol Cancer Ther.
, vol.10
, pp. 209-217
-
-
Tsimberidou, A.M.1
Takimoto, C.H.2
Moulder, S.3
-
13
-
-
33749026073
-
Phase i study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma
-
Rivera E, Meyers C, Groves M, et al. Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma. Cancer. 2006;107: 1348-1354.
-
(2006)
Cancer.
, vol.107
, pp. 1348-1354
-
-
Rivera, E.1
Meyers, C.2
Groves, M.3
-
14
-
-
38649139119
-
A phase II trial of vinorelbine and intensive temozolomide for patients with recurrent or progressive brain metastases
-
Iwamoto FM, Omuro AM, Raizer JJ, et al. A phase II trial of vinorelbine and intensive temozolomide for patients with recurrent or progressive brain metastases. J Neurooncol. 2008;87:85-90.
-
(2008)
J Neurooncol.
, vol.87
, pp. 85-90
-
-
Iwamoto, F.M.1
Omuro, A.M.2
Raizer, J.J.3
-
15
-
-
82055202474
-
A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a
-
Chi KN, Beardsley E, Eigl BJ, et al. A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a. Ann Oncol. 2012;23:53-58.
-
(2012)
Ann Oncol.
, vol.23
, pp. 53-58
-
-
Chi, K.N.1
Beardsley, E.2
Eigl, B.J.3
-
17
-
-
84861994651
-
Patupilone (epothilone B) for recurrent glioblastoma: Clinical outcome and translational analysis of a single-institution phase I/II trial
-
Oehler C, Frei K, Rushing EJ, et al. Patupilone (epothilone B) for recurrent glioblastoma: clinical outcome and translational analysis of a single-institution phase I/II trial. Oncology. 2012;83:1-9.
-
(2012)
Oncology.
, vol.83
, pp. 1-9
-
-
Oehler, C.1
Frei, K.2
Rushing, E.J.3
-
18
-
-
84868482683
-
Gli family transcription factors are drivers of patupilone resistance in ovarian cancer
-
Mozzetti S, Martinelli E, Raspaglio G, et al. Gli family transcription factors are drivers of patupilone resistance in ovarian cancer. Biochem Pharmacol. 2012;84:1409-1418.
-
(2012)
Biochem Pharmacol.
, vol.84
, pp. 1409-1418
-
-
Mozzetti, S.1
Martinelli, E.2
Raspaglio, G.3
-
19
-
-
79959649836
-
Specific beta-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells
-
Gan PP, McCarroll JA, Byrne FL, et al. Specific beta-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells. PLoS One. 2011;6:e21717.
-
(2011)
PLoS One.
, vol.6
-
-
Gan, P.P.1
McCarroll, J.A.2
Byrne, F.L.3
-
20
-
-
0033120802
-
Front-line chemotherapy with cisplatinandetoposideforpatients with brainmetastases frombreast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: A prospective study
-
Franciosi V, Cocconi G, Michiara M, et al. Front-line chemotherapy with cisplatinandetoposideforpatients with brainmetastases frombreast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: a prospective study. Cancer. 1999;85:1599-1605.
-
(1999)
Cancer.
, vol.85
, pp. 1599-1605
-
-
Franciosi, V.1
Cocconi, G.2
Michiara, M.3
-
21
-
-
0022530993
-
Chemotherapy induces regression of brain metastases in breast carcinoma
-
Rosner D, Nemoto T, Lane WW. Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer. 1986;58:832-839.
-
(1986)
Cancer.
, vol.58
, pp. 832-839
-
-
Rosner, D.1
Nemoto, T.2
Lane, W.W.3
-
22
-
-
77949638554
-
Dose-dense temozolomide regimen for the treatment of brainmetastases frommelanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: A multicenter phase II study
-
Siena S, Crino L, Danova M, et al. Dose-dense temozolomide regimen for the treatment of brainmetastases frommelanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study. Ann Oncol. 2010;21:655-661.
-
(2010)
Ann Oncol.
, vol.21
, pp. 655-661
-
-
Siena, S.1
Crino, L.2
Danova, M.3
-
23
-
-
77953561380
-
Phase i trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies
-
Fogh S, Machtay M, Werner-Wasik M, et al. Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys. 2010;77:1009-1016.
-
(2010)
Int J Radiat Oncol Biol Phys.
, vol.77
, pp. 1009-1016
-
-
Fogh, S.1
Machtay, M.2
Werner-Wasik, M.3
-
24
-
-
84896993281
-
Anopen-label, multi-center, phase II study of patupilone (EPO906), in the treatment of recurrent or progressive brain metastases in patients with non-small cell lung cancer (NSCLC)
-
Paper presented at March 16, 2013; San Diego, CA
-
Nayak L, Abrey L, DeAngelis L, et al. Anopen-label, multi-center, phase II study of patupilone (EPO906), in the treatment of recurrent or progressive brain metastases in patients with non-small cell lung cancer (NSCLC). Paper presented at: American Academy of Neurology Annual Meeting; March 16, 2013; San Diego, CA.
-
American Academy of Neurology Annual Meeting
-
-
Nayak, L.1
Abrey, L.2
Deangelis, L.3
-
25
-
-
82255177135
-
A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancerand brain metastases
-
Freedman RA, Bullitt E, Sun L, et al. A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancerand brain metastases. Clin Breast Cancer. 2011;11:376-383.
-
(2011)
Clin Breast Cancer.
, vol.11
, pp. 376-383
-
-
Freedman, R.A.1
Bullitt, E.2
Sun, L.3
-
26
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008;26:1993-1999.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
Liu, M.C.3
-
27
-
-
63149110733
-
Multicenter phase II study of lapatinib in patients with brain metastases fromHER2-positive breast cancer
-
Lin NU, Dieras V, Paul D, et al. Multicenter phase II study of lapatinib in patients with brain metastases fromHER2-positive breast cancer. Clin Cancer Res. 2009;15:1452-1459.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 1452-1459
-
-
Lin, N.U.1
Dieras, V.2
Paul, D.3
-
28
-
-
84879695172
-
Tubulin-beta-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones
-
Roque DM, Bellone S, English DP, et al. Tubulin-beta-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones. Cancer. 2013;119:2582-2592.
-
(2013)
Cancer.
, vol.119
, pp. 2582-2592
-
-
Roque, D.M.1
Bellone, S.2
English, D.P.3
|