The use of amino acids to prepare physically and conformationally stable spray-dried IgG with enhanced aerosol performance

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 163-171

  Faghihi, Homa ^a   Vatanara, Alireza ^a   Najafabadi, Abdolhosein Rouholamini ^a   Ramezani, Vahid ^b   Gilani, Kambiz ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Shahid Sadough University of Medical Sciences   (Iran)

Author keywords

Aerosol performance; Amino acid; IgG; Spray drying; Stability

Indexed keywords

ARGININE; CYSTEINE; GLYCINE; IMMUNOGLOBULIN G; LEUCINE; LYSINE; PHENYLALANINE; AEROSOL; AMINO ACID;

AEROSOL; AGGREGATION; AQUEOUS SOLUTION; ARTICLE; DRUG CONFORMATION; DRUG FORMULATION; DRY POWDER; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; ISOELECTRIC POINT; MOLECULAR STABILITY; PARTICLE SIZE; PHYSICAL PARAMETERS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPRAY DRYING; STORAGE TEMPERATURE; THERMODYNAMICS; X RAY POWDER DIFFRACTION; CHEMISTRY; DRUG STABILITY; MEDICINAL CHEMISTRY; POWDER DIFFRACTION; PROTEIN CONFORMATION; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

AEROSOLS; AMINO ACIDS; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; IMMUNOGLOBULIN G; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDER DIFFRACTION; PROTEIN CONFORMATION; X-RAY DIFFRACTION;

EID: 84896958862     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.020     Document Type: Article

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