3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8121-8134

  Fujiwara, Tohru ^a   Saitoh, Haruka ^a   Inoue, Ai ^a   Kobayashi, Masahiro ^a   Okitsu, Yoko ^a   Katsuoka, Yuna ^a   Fukuhara, Noriko ^a   Onishi, Yasushi ^a   Ishizawa, Kenichi ^a,b   Ichinohasama, Ryo ^a   Harigae, Hideo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL DEATH; PROTEINS;

EPIGENETIC SILENCING; ERYTHROID DIFFERENTIATION; HEMATOLOGICAL DISEASE; HEMATOLOGICAL MALIGNANCIES; QUANTITATIVE RT-PCR; THERAPEUTIC APPLICATION; TRANSCRIPTIONAL PROFILING; TRANSCRIPTIONAL REPRESSION;

GENE EXPRESSION;

3 DEAZANEPLANOCIN A; COREPRESSOR PROTEIN; ERYTHROCYTE BAND 4.2 PROTEIN; ETO2 PROTEIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; EPB42 GENE; ERYTHROID CELL; ERYTHROPOIESIS; GENE; GENE INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLC4A1 GENE;

DZNEP; ERYTHROPOEISIS; ETO2; EZH2; GENE TRANSCRIPTION; HEMOGLOBIN; HISTONE DEACETYLASE; HISTONE METHYLATION;

ADENOSINE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ERYTHROBLASTS; ERYTHROID CELLS; GENE EXPRESSION REGULATION; HUMANS; K562 CELLS; METHYLTRANSFERASES; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84896947233     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.548651     Document Type: Article

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