Identification of halohydrin dehalogenase mutants that resist COBE inhibition

Biotechnology and Bioprocess Engineering

Volumn 19, Issue 1, 2014, Pages 26-32

  Chen, Shao Yun ^a   He, Xiu Juan ^a   Wu, Jian Ping ^a   Xu, Gang ^a   Yang, Li Rong ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

activity inhibition; COBE; halohydrin dehalogenase; protein semi rational design

Indexed keywords

HYDROGEN BONDS;

ALCOHOL DEHYDROGENASE; COBE; ECONOMIC AND ENVIRONMENTAL BENEFITS; HALOHYDRIN DEHALOGENASE; MOLECULAR SIMULATIONS; REVERSIBLE INHIBITIONS; SATURATION MUTAGENESIS; SUBSTRATE INHIBITION KINETICS;

MUTAGENESIS;

ACETOACETIC ACID DERIVATIVE; ALCOHOL DEHYDROGENASE; ATORVASTATIN; BUTYRIC ACID; ENZYME; ETHYL 4 CHLOROACETOACETATE; ETHYL 4 CYANO 3 HYDROXYBUTYRATE; HALOHYDRIN DEHALOGENASE; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; INHIBITION KINETICS; MOLECULAR DOCKING; ONE POT SYNTHESIS; POINT MUTATION; SIMULATION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

EID: 84896919883     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-013-0457-3     Document Type: Article

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